6CJG
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![BU of 6cjg by Molmil](/molmil-images/mine/6cjg) | Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46 | Descriptor: | 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Petrunak, E.M, Stuckey, J.A. | Deposit date: | 2018-02-26 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem., 61, 2018
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3P8M
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![BU of 3p8m by Molmil](/molmil-images/mine/3p8m) | Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide dimerized by leucine zipper | Descriptor: | Dynein light chain 2, General control protein GCN4 | Authors: | Rapali, P, Radnai, L, Suveges, D, Hetenyi, C, Harmat, V, Tolgyesi, F, Wahlgren, W.Y, Katona, G, Nyitray, L, Pal, G. | Deposit date: | 2010-10-14 | Release date: | 2011-08-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. Plos One, 6, 2011
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8BFH
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![BU of 8bfh by Molmil](/molmil-images/mine/8bfh) | CNOT11 | Descriptor: | CCR4-NOT transcription complex subunit 11 | Authors: | Basquin, J, Ozgur, S, Conti, E. | Deposit date: | 2022-10-26 | Release date: | 2022-12-28 | Last modified: | 2023-02-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions. Cell Rep, 42, 2023
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1B47
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![BU of 1b47 by Molmil](/molmil-images/mine/1b47) | STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70 | Descriptor: | CALCIUM ION, CBL | Authors: | Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. | Deposit date: | 1999-01-06 | Release date: | 1999-04-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
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5CRC
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![BU of 5crc by Molmil](/molmil-images/mine/5crc) | Structure of the SdeA DUB Domain | Descriptor: | SdeA | Authors: | Sheedlo, M.J, Qiu, J, Tan, Y, Paul, L.N, Luo, Z.Q, Das, C. | Deposit date: | 2015-07-22 | Release date: | 2015-11-25 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.853 Å) | Cite: | Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc.Natl.Acad.Sci.USA, 112, 2015
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5URH
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![BU of 5urh by Molmil](/molmil-images/mine/5urh) | CYPOR/D632A with NADP+ | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Xia, C, Kim, J.J. | Deposit date: | 2017-02-10 | Release date: | 2018-02-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer. Biochemistry, 57, 2018
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1R8X
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![BU of 1r8x by Molmil](/molmil-images/mine/1r8x) | Crystal Structure of Mouse Glycine N-Methyltransferase (Tetragonal Form) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, glycine N-methyltransferase | Authors: | Pakhomova, S, Luka, Z, Wagner, C, Newcomer, M.E. | Deposit date: | 2003-10-28 | Release date: | 2004-09-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Proteins, 57, 2004
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1R5O
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![BU of 1r5o by Molmil](/molmil-images/mine/1r5o) | crystal structure analysis of sup35 complexed with GMPPNP | Descriptor: | Eukaryotic peptide chain release factor GTP-binding subunit, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Kong, C, Song, H. | Deposit date: | 2003-10-11 | Release date: | 2004-05-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe Mol.Cell, 14, 2004
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8BFJ
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![BU of 8bfj by Molmil](/molmil-images/mine/8bfj) | CNOT11-GGNBP2 complex | Descriptor: | 1,2-ETHANEDIOL, CCR4-NOT transcription complex subunit 11, Gametogenetin-binding protein 2 | Authors: | Basquin, J, Ozgur, S, Conti, E. | Deposit date: | 2022-10-26 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions. Cell Rep, 42, 2023
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8OFM
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![BU of 8ofm by Molmil](/molmil-images/mine/8ofm) | |
4RF2
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![BU of 4rf2 by Molmil](/molmil-images/mine/4rf2) | |
1JBR
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![BU of 1jbr by Molmil](/molmil-images/mine/1jbr) | Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor | Descriptor: | 31-mer SRD RNA analog, 5'-R(*GP*CP*GP*CP*UP*CP*CP*UP*CP*AP*GP*UP*AP*CP*GP*AP*GP*(A23))-3', 5'-R(*GP*GP*AP*AP*CP*CP*GP*GP*AP*GP*CP*GP*C)-3', ... | Authors: | Yang, X, Gerczei, T, Glover, L, Correll, C.C. | Deposit date: | 2001-06-06 | Release date: | 2001-10-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of restrictocin-inhibitor complexes with implications for RNA recognition and base flipping. Nat.Struct.Biol., 8, 2001
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4REC
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![BU of 4rec by Molmil](/molmil-images/mine/4rec) | A nuclease-DNA complex form 3 | Descriptor: | DNA (40-MER), Fanconi-associated nuclease 1, IODIDE ION | Authors: | Zhao, Q, Xue, X, Longerich, S, Sung, P, Xiong, Y. | Deposit date: | 2014-09-22 | Release date: | 2014-12-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer. Nat Commun, 5, 2014
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8H24
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![BU of 8h24 by Molmil](/molmil-images/mine/8h24) | Leucine-rich alpha-2-glycoprotein 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich alpha-2-glycoprotein, SULFATE ION | Authors: | Won, S.Y, Park, B.S, Lee, D.S, Kim, H.M, Han, A, Yang, J. | Deposit date: | 2022-10-04 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation. Exp.Mol.Med., 55, 2023
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5NDC
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![BU of 5ndc by Molmil](/molmil-images/mine/5ndc) | Structure of ba3-type cytochrome c oxidase from Thermus thermophilus by serial femtosecond crystallography | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide IIA, ... | Authors: | Andersson, R, Safari, C, Dods, R, Nango, E, Tanaka, R, Nakane, T, Tono, K, Joti, Y, Bath, P, Dunevall, E, Bosman, E, Nureki, O, Iwata, S, Neutze, R, Branden, G. | Deposit date: | 2017-03-08 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature. Sci Rep, 7, 2017
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7RNJ
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![BU of 7rnj by Molmil](/molmil-images/mine/7rnj) | S2P6 Fab fragment bound to the SARS-CoV/SARS-CoV-2 spike stem helix peptide | Descriptor: | Monoclonal antibody S2P6 Fab heavy chain, Monoclonal antibody S2P6 Fab light chain, SULFATE ION, ... | Authors: | Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M, Sauer, M.M, Veesler, D. | Deposit date: | 2021-07-29 | Release date: | 2021-08-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Broad betacoronavirus neutralization by a stem helix-specific human antibody. Science, 373, 2021
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5V92
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![BU of 5v92 by Molmil](/molmil-images/mine/5v92) | |
8BEF
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![BU of 8bef by Molmil](/molmil-images/mine/8bef) | Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (CI membrane core) | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ... | Authors: | Klusch, N, Kuehlbrandt, W. | Deposit date: | 2022-10-21 | Release date: | 2023-01-11 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (2.13 Å) | Cite: | Cryo-EM structure of the respiratory I + III 2 supercomplex from Arabidopsis thaliana at 2 angstrom resolution. Nat.Plants, 9, 2023
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4QVB
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![BU of 4qvb by Molmil](/molmil-images/mine/4qvb) | Mycobacterium tuberculosis protein Rv1155 in complex with co-enzyme F420 | Descriptor: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, COENZYME F420, ... | Authors: | Mashalidis, E.H, Gittis, A.G, Tomczak, A, Abell, C, Barry III, C.E, Garboczi, D.N. | Deposit date: | 2014-07-14 | Release date: | 2015-02-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis. Protein Sci., 24, 2015
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5N6C
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![BU of 5n6c by Molmil](/molmil-images/mine/5n6c) | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate | Descriptor: | D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Unterlass, J.E, Basle, A, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. | Deposit date: | 2017-02-14 | Release date: | 2017-11-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget, 8, 2017
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8BEE
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![BU of 8bee by Molmil](/molmil-images/mine/8bee) | |
8K7I
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![BU of 8k7i by Molmil](/molmil-images/mine/8k7i) | Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2-(hydroxymethyl)-5-((methylamino)methyl)pyrrolidine-3,4-diol | Descriptor: | (2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-5-(methylaminomethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | Deposit date: | 2023-07-26 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K7J
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![BU of 8k7j by Molmil](/molmil-images/mine/8k7j) | Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-((dimethylamino)methyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-[(dimethylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | Deposit date: | 2023-07-26 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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1RFU
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![BU of 1rfu by Molmil](/molmil-images/mine/1rfu) | Crystal structure of pyridoxal kinase complexed with ADP and PLP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, ZINC ION, ... | Authors: | Liang, D.-C, Jiang, T, Li, M.-H. | Deposit date: | 2003-11-10 | Release date: | 2004-04-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Conformational changes in the reaction of pyridoxal kinase J.BIOL.CHEM., 279, 2004
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1B54
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![BU of 1b54 by Molmil](/molmil-images/mine/1b54) | CRYSTAL STRUCTURE OF A YEAST HYPOTHETICAL PROTEIN-A STRUCTURE FROM BNL'S HUMAN PROTEOME PROJECT | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, YEAST HYPOTHETICAL PROTEIN | Authors: | Swaminathan, S, Eswaramoorthy, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 1999-01-12 | Release date: | 1999-01-27 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr.,Sect.D, 59, 2003
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