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4XO3	Crystal Structure of E. coli Aminopeptidase N in complex with L-Leucine Descriptor: Aminopeptidase N, GLYCEROL, LEUCINE, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-16 Release date: 2016-01-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of E. coli Aminopeptidase N in complex with L-Leucine To Be Published
4XMX	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with Bestatin Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R, Kishor, C. Deposit date: 2015-01-15 Release date: 2016-02-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with Bestatin To Be Published
4XN5	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Phenylalanine Descriptor: Aminopeptidase N, GLYCEROL, MALONATE ION, ... Authors: Addlagatta, A, Gumpena, R, Kishor, C. Deposit date: 2015-01-15 Release date: 2016-02-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Phenylalanine To Be Published
4XMW	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-aspartic acid Descriptor: ASPARTIC ACID, Aminopeptidase N, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R, Kishor, C. Deposit date: 2015-01-15 Release date: 2016-02-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-aspartic acid To Be Published
4XMV	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Arginine Descriptor: ARGININE, Aminopeptidase N, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R, Kishor, C. Deposit date: 2015-01-15 Release date: 2016-02-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-arginine To Be Published
4XN1	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate Descriptor: Aminopeptidase N, GLUTAMIC ACID, MALONATE ION, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-15 Release date: 2016-03-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate To Be Published
4XNB	Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine Descriptor: (3S)-3-AMINO-4-PHENYLBUTANOIC ACID, Aminopeptidase N, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-15 Release date: 2016-03-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine To Be Published
4XO5	Crystal Structure of E. coli Aminopeptidase N in complex with L-Glutamate Descriptor: Aminopeptidase N, GLUTAMIC ACID, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-16 Release date: 2016-01-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal Structure of E. coli Aminopeptidase N in complex with L-Glutamate To Be Published
4Z7I	Crystal structure of insulin regulated aminopeptidase in complex with ligand Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ... Authors: Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E. Deposit date: 2015-04-07 Release date: 2015-08-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195, 2015
4ZW5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f Descriptor: M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW6	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW3	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX4	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
5AB2	Crystal structure of aminopeptidase ERAP2 with ligand Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Mpakali, A, Giastas, P, Saridakis, E, Mavridis, I.M, Stratikos, E. Deposit date: 2015-07-31 Release date: 2015-09-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.729 Å) Cite: Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
5AEN	Structure of human Leukotriene A4 hydrolase in complex with inhibitor dimethyl(2- (4-phenoxyphenoxy)ethyl)amine Descriptor: IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine, ... Authors: Moser, D, Wittmann, S.K, Kramer, J, Blocher, R, Achenbach, J, Pogoryelov, D, Proschak, E. Deposit date: 2015-01-06 Release date: 2015-02-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.864 Å) Cite: Peng: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation and Virtual Screening for Novel Ligands of Lta4H. J.Chem.Inf.Model., 55, 2015
4ZQT	Crystal structure of PfA-M1 with virtual ligand inhibitor Descriptor: (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, GLYCEROL, M1 family aminopeptidase, ... Authors: Ruggeri, C, Drinkwater, N, McGowan, S. Deposit date: 2015-05-11 Release date: 2015-10-07 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.981 Å) Cite: Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015
5BPP	Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ Descriptor: 2-(4-butoxyphenyl)-N-hydroxyacetamide, ACETATE ION, Leukotriene A-4 hydrolase, ... Authors: Huang, J, Dong, N.N, Xiao, Q, Ou, P.Y, Wu, D, Lu, W.Q. Deposit date: 2015-05-28 Release date: 2016-08-10 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H Sci Rep, 6, 2016
4ZW7	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
5AB0	Crystal structure of aminopeptidase ERAP2 with ligand Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Mpakali, A, Giastas, P, Saridakis, E, Stratikos, E. Deposit date: 2015-07-31 Release date: 2015-09-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
4ZW8	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX6	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX3	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b Descriptor: DIMETHYL SULFOXIDE, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4HOM	Crystal structure of porcine aminopeptidase-N complexed with substance P Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Chen, L, Lin, Y.L, Peng, G, Li, F. Deposit date: 2012-10-22 Release date: 2012-10-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
4JBS	Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... Authors: Saridakis, E, Birtley, J, Stratikos, E, Mavridis, I.M. Deposit date: 2013-02-20 Release date: 2013-12-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.789 Å) Cite: Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc.Natl.Acad.Sci.USA, 110, 2013

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