5DKY
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![BU of 5dky by Molmil](/molmil-images/mine/5dky) | Crystal structure of glucosidase II alpha subunit (DNJ-bound from) | Descriptor: | 1-DEOXYNOJIRIMYCIN, Alpha glucosidase-like protein | Authors: | Satoh, T, Toshimori, T, Yan, G, Yamaguchi, T, Kato, K. | Deposit date: | 2015-09-04 | Release date: | 2016-01-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control. Sci Rep, 6, 2016
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5DLA
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![BU of 5dla by Molmil](/molmil-images/mine/5dla) | Structure of Tetragonal Lysozyme solved by UWO Students | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C | Authors: | Bednarski, R, Cirricione, N, Greco, A, Hodgson, R, Kent, S, McGowan, J, Notherm, B, Patt, M, Vue, L, Bianchetti, C.M. | Deposit date: | 2015-09-04 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Structure of Tetragonal Lysozyme in complex with Iodine solved by UWO Students To Be Published
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5DLW
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![BU of 5dlw by Molmil](/molmil-images/mine/5dlw) | Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA) | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, ... | Authors: | Keune, W.J, Heidebrecht, T, Joosten, R.P, Perrakis, A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7, 2016
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4N0U
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![BU of 4n0u by Molmil](/molmil-images/mine/4n0u) | Ternary complex between Neonatal Fc receptor, serum albumin and Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ... | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2013-10-02 | Release date: | 2014-02-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms. J.Biol.Chem., 289, 2014
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4N1L
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![BU of 4n1l by Molmil](/molmil-images/mine/4n1l) | Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions | Descriptor: | NACHT, LRR and PYD domains-containing protein 14 | Authors: | Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H. | Deposit date: | 2013-10-04 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014
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5E9Z
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![BU of 5e9z by Molmil](/molmil-images/mine/5e9z) | Cytochrome P450 BM3 mutant M11 | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bifunctional cytochrome P450/NADPH--P450 reductase, FE (II) ION, ... | Authors: | Capoferri, L, Leth, R, ter Haar, E, Mohanty, A.K, Grootenhuis, D.J, Vottero, E, Commandeur, J.N.M, Vermeulen, N.P.E, Jorgensen, F.S, Olsen, L, Geerke, D.P. | Deposit date: | 2015-10-15 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins, 84, 2016
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3CDX
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![BU of 3cdx by Molmil](/molmil-images/mine/3cdx) | Crystal structure of succinylglutamatedesuccinylase/aspartoacylase from Rhodobacter sphaeroides | Descriptor: | CALCIUM ION, Succinylglutamatedesuccinylase/aspartoacylase | Authors: | Bonanno, J.B, Rutter, M, Bain, K.T, Iizuka, M, Patterson, K, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-02-27 | Release date: | 2008-03-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of succinylglutamatedesuccinylase/aspartoacylase from Rhodobacter sphaeroides. To be Published
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2ZSK
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![BU of 2zsk by Molmil](/molmil-images/mine/2zsk) | Crystal structure of PH1733, an aspartate racemase homologue, from Pyrococcus horikoshii OT3 | Descriptor: | 226aa long hypothetical aspartate racemase | Authors: | Kita, A, Tasaki, S, Yohda, M, Miki, K. | Deposit date: | 2008-09-12 | Release date: | 2008-10-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of PH1733, an aspartate racemase homologue, from pyrococcus horikoshii OT3 Proteins, 74, 2009
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4CQC
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![BU of 4cqc by Molmil](/molmil-images/mine/4cqc) | The reaction mechanism of the N-isopropylammelide isopropylaminohydrolase AtzC: insights from structural and mutagenesis studies | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, N-ISOPROPYLAMMELIDE ISOPROPYL AMIDOHYDROLASE, ... | Authors: | Balotra, S, Newman, J, French, N.G, Peat, T.S, Scott, C. | Deposit date: | 2014-02-13 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, Atzc Plos One, 1, 2015
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4OT4
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![BU of 4ot4 by Molmil](/molmil-images/mine/4ot4) | |
2A2J
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![BU of 2a2j by Molmil](/molmil-images/mine/2a2j) | Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis | Descriptor: | Pyridoxamine 5'-phosphate oxidase | Authors: | Pedelacq, J.-D, Rho, B.-S, Kim, C.-Y, Waldo, G.S, Lekin, T.P, Segelke, B.W, Rupp, B, Hung, L.-W, Kim, S.-I, Terwilliger, T.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2005-06-22 | Release date: | 2005-08-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis. Proteins, 62, 2005
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2A8X
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![BU of 2a8x by Molmil](/molmil-images/mine/2a8x) | Crystal Structure of Lipoamide Dehydrogenase from Mycobacterium tuberculosis | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Rajashankar, K.R, Bryk, R, Kniewel, R, Buglino, J.A, Nathan, C.F, Lima, C.D. | Deposit date: | 2005-07-10 | Release date: | 2005-08-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis J.Biol.Chem., 280, 2005
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4P0M
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![BU of 4p0m by Molmil](/molmil-images/mine/4p0m) | Crystal structure of an evolved putative penicillin-binding protein homolog, Rv2911, from Mycobacterium tuberculosis | Descriptor: | D-alanyl-D-alanine carboxypeptidase | Authors: | Krieger, I, Yu, M, Bursey, E, Hung, L.-W, Terwilliger, T.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2014-02-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Subfamily-Specific Adaptations in the Structures of Two Penicillin-Binding Proteins from Mycobacterium tuberculosis. Plos One, 9, 2014
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2DLD
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![BU of 2dld by Molmil](/molmil-images/mine/2dld) | D-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-LACTATE DEHYDROGENASE, OXAMIC ACID | Authors: | Dunn, C.R, Holbrook, J.J. | Deposit date: | 1995-10-28 | Release date: | 1996-03-14 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Dehydrogenases Engineering to Correct Substrate Inhibition in a Commercial Dehydrogenase To be Published
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3CXZ
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![BU of 3cxz by Molmil](/molmil-images/mine/3cxz) | |
2FDW
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![BU of 2fdw by Molmil](/molmil-images/mine/2fdw) | Crystal Structure Of Human Microsomal P450 2A6 with the inhibitor (5-(Pyridin-3-yl)furan-2-yl)methanamine bound | Descriptor: | (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Yano, J.K, Stout, C.D, Johnson, E.F. | Deposit date: | 2005-12-14 | Release date: | 2006-11-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49, 2006
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3D6N
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![BU of 3d6n by Molmil](/molmil-images/mine/3d6n) | Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase | Descriptor: | Aspartate carbamoyltransferase, CITRATE ANION, Dihydroorotase, ... | Authors: | Edwards, B.F.P. | Deposit date: | 2008-05-20 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. Biochemistry, 48, 2009
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4EJJ
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![BU of 4ejj by Molmil](/molmil-images/mine/4ejj) | Human Cytochrome P450 2A6 in complex with nicotine | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE | Authors: | DeVore, N.M, Scott, E.E. | Deposit date: | 2012-04-06 | Release date: | 2012-06-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. J.Biol.Chem., 287, 2012
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2CUK
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![BU of 2cuk by Molmil](/molmil-images/mine/2cuk) | |
4NST
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![BU of 4nst by Molmil](/molmil-images/mine/4nst) | Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | Authors: | Boesken, C.A, Farnung, L, Anand, K, Geyer, M. | Deposit date: | 2013-11-29 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
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4NPF
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![BU of 4npf by Molmil](/molmil-images/mine/4npf) | High-resolution structure of two tandem B domains of staphylococcal protein A connected by the conserved linker | Descriptor: | Immunoglobulin G-binding protein A | Authors: | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | Deposit date: | 2013-11-21 | Release date: | 2014-10-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. Structure, 22, 2014
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3CV9
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![BU of 3cv9 by Molmil](/molmil-images/mine/3cv9) | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Hayashi, K, Sugimoto, H, Shinkyo, R, Yamada, M, Ikeda, S, Ikushiro, S, Kamakura, M, Shiro, Y, Sakaki, T. | Deposit date: | 2008-04-18 | Release date: | 2008-11-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1 Biochemistry, 47, 2008
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2FDU
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![BU of 2fdu by Molmil](/molmil-images/mine/2fdu) | Microsomal P450 2A6 with the inhibitor N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound | Descriptor: | Cytochrome P450 2A6, N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Yano, J.K, Stout, C.D, Johnson, E.F. | Deposit date: | 2005-12-14 | Release date: | 2006-11-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49, 2006
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4G47
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![BU of 4g47 by Molmil](/molmil-images/mine/4g47) | Structure of cytochrome P450 CYP121 in complex with 4-(1H-1,2,4-triazol-1-yl)phenol | Descriptor: | 4-(1H-1,2,4-triazol-1-yl)phenol, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Hudson, S.A, McLean, K.J, Surade, S, Yang, Y.-Q, Leys, D, Ciulli, A, Munro, A.W, Abell, C. | Deposit date: | 2012-07-16 | Release date: | 2012-09-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121 Angew.Chem.Int.Ed.Engl., 51, 2012
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2FKB
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![BU of 2fkb by Molmil](/molmil-images/mine/2fkb) | Crystal structure of a putative enzyme (possible Nudix hydrolase) from Escherichia Coli K12 | Descriptor: | ACETATE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Nocek, B, Evdokimova, E, Kudritska, M, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-01-04 | Release date: | 2006-02-21 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a putative enzyme (possible Nudix hydrolase) from Escherichia Coli K12 To be Published
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