2A2J

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis

Summary for 2A2J

• Entry DOI: 10.2210/pdb2a2j/pdb
• Descriptor: Pyridoxamine 5'-phosphate oxidase (2 entities in total)
• Functional Keywords: beta barrel, structural genomics, mycobacterium tuberculosis structural proteomics project, xmtb, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 55211.77

Authors

Pedelacq, J.-D.,Rho, B.-S.,Kim, C.-Y.,Waldo, G.S.,Lekin, T.P.,Segelke, B.W.,Rupp, B.,Hung, L.-W.,Kim, S.-I.,Terwilliger, T.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (deposition date: 2005-06-22, release date: 2005-08-23, Last modification date: 2024-10-09)

Primary citation

Pedelacq, J.-D.,Rho, B.-S.,Kim, C.-Y.,Waldo, G.S.,Lekin, T.P.,Segelke, B.W.,Rupp, B.,Hung, L.-W.,Kim, S.-I.,Terwilliger, T.C.
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.
Proteins, 62:563-569, 2005

PubMed Abstract: The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family.

PubMed: 16374842
DOI: 10.1002/prot.20824

Experimental method

X-RAY DIFFRACTION (2.5 Å)