3CV9

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3

Summary for 3CV9

Entry DOI	10.2210/pdb3cv9/pdb
Related	2ZBX 2ZBY 2ZBZ 3CV8
Descriptor	Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	p450, beta prism, heme, iron, metal-binding, monooxygenase, oxidoreductase
Biological source	Streptomyces griseolus
Total number of polymer chains	1
Total formula weight	45938.75
Authors	Hayashi, K.,Sugimoto, H.,Shinkyo, R.,Yamada, M.,Ikeda, S.,Ikushiro, S.,Kamakura, M.,Shiro, Y.,Sakaki, T. (deposition date: 2008-04-18, release date: 2008-11-04, Last modification date: 2023-11-01)
Primary citation	Hayashi, K.,Sugimoto, H.,Shinkyo, R.,Yamada, M.,Ikeda, S.,Ikushiro, S.,Kamakura, M.,Shiro, Y.,Sakaki, T. Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1 Biochemistry, 47:11964-11972, 2008 Cited by PubMed: 18937506 DOI: 10.1021/bi801222d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation