2ZBZ

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D3

Summary for 2ZBZ

• Entry DOI: 10.2210/pdb2zbz/pdb
• Related: 2ZBX 2ZBY
• Descriptor: Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: p450, beta prism, heme, iron, metal-binding, monooxygenase, oxidoreductase
• Biological source: Streptomyces griseolus
• Total number of polymer chains: 1
• Total formula weight: 46024.86

Authors

Sugimoto, H.,Shinkyo, R.,Hayashi, K.,Yoneda, S.,Yamada, M.,Kamakura, M.,Ikushiro, S.,Shiro, Y.,Sakaki, T. (deposition date: 2007-10-30, release date: 2008-04-08, Last modification date: 2023-11-01)

• Primary citation: Sugimoto, H.,Shinkyo, R.,Hayashi, K.,Yoneda, S.,Yamada, M.,Kamakura, M.,Ikushiro, S.,Shiro, Y.,Sakaki, T.; Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3; Biochemistry, 47:4017-4027, 2008; PubMed: 18314962; DOI: 10.1021/bi7023767

Experimental method

X-RAY DIFFRACTION (1.9 Å)