3CV9
Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450-SU1 | polymer | 412 | 44905.6 | 1 | UniProt (P18326) | Streptomyces griseolus | P450-CVA1, CYP105A1 |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL | non-polymer | 416.6 | 1 | Chemie (VDX) PubChem (21158442) PubChem (2524) PubChem (176541417) PubChem (22811021) PubChem (25056915) PubChem (25144925) PubChem (177626446) PubChem (36083) PubChem (16759357) PubChem (44348524) PubChem (44445686) PubChem (134070) PubChem (50990009) PubChem (25244372) PubChem (53675483) PubChem (53846420) PubChem (53846421) PubChem (53846422) PubChem (53846423) PubChem (53846424) PubChem (53846425) PubChem (53846429) PubChem (53846432) PubChem (53846434) PubChem (53846435) PubChem (56675037) PubChem (57069375) PubChem (57853710) PubChem (59072033) PubChem (59824443) PubChem (59966627) PubChem (59966628) PubChem (59966641) PubChem (59966648) PubChem (59966656) PubChem (60120675) PubChem (46780152) PubChem (71296883) PubChem (71586635) PubChem (71699993) PubChem (53846427) PubChem (57358782) PubChem (73707427) PubChem (73946427) PubChem (57824615) PubChem (87060437) PubChem (88093945) PubChem (88093948) PubChem (88205154) PubChem (89082395) PubChem (89187208) PubChem (89735852) PubChem (90909703) PubChem (71434160) PubChem (71776638) PubChem (5283736) PubChem (5283739) PubChem (5283740) PubChem (5283741) PubChem (5283742) PubChem (87065662) PubChem (90942134) PubChem (90997437) PubChem (91170688) PubChem (91172822) PubChem (91400094) PubChem (91442807) PubChem (91543944) PubChem (90690610) PubChem (91507903) PubChem (91884833) PubChem (5280453) PubChem (5353466) PubChem (5371993) PubChem (5283737) PubChem (95566291) PubChem (98043898) PubChem (98043896) PubChem (118719297) PubChem (6439628) PubChem (91884755) PubChem (124554638) PubChem (9844833) PubChem (9953732) PubChem (6376279) PubChem (6434112) PubChem (6437079) PubChem (92974077) PubChem (95566292) PubChem (98043897) PubChem (98043899) PubChem (98116576) PubChem (98621118) PubChem (133655777) PubChem (101088599) PubChem (101099404) PubChem (102426204) PubChem (102552746) PubChem (117828099) PubChem (118855589) PubChem (9802028) PubChem (9823224) PubChem (9866622) PubChem (122451302) PubChem (12096001) PubChem (12095999) PubChem (9909846) PubChem (9963516) PubChem (123249588) PubChem (10093379) PubChem (10180181) PubChem (10180182) PubChem (13019064) PubChem (124220088) PubChem (10873438) PubChem (11112510) PubChem (11292963) PubChem (142186967) PubChem (142965989) PubChem (124584674) PubChem (124604783) PubChem (12096000) PubChem (13019045) PubChem (13019047) PubChem (13019052) PubChem (13019062) PubChem (13019065) PubChem (13019066) PubChem (13019068) PubChem (13019072) PubChem (13019077) PubChem (125032907) PubChem (129010338) PubChem (129627816) PubChem (129631814) PubChem (131954609) PubChem (134693124) PubChem (134694664) PubChem (139024314) PubChem (154790143) PubChem (154831899) PubChem (156599239) PubChem (162489847) PubChem (162904206) PubChem (163285334) PubChem (164576789) PubChem (166640002) PubChem (171114678) PubChem (171157379) PubChem (172966559) PubChem (173519260) | |||
| 4 | D (A) | water | water | 18.0 | 463 | Chemie (HOH) |
Sequence modifications
A: 1 - 406 (UniProt: P18326)
| PDB | External Database | Details |
|---|---|---|
| Ala 73 | Arg 73 | engineered mutation |
| Ala 84 | Arg 84 | engineered mutation |
| Gln 308 | His 308 | SEE REMARK 999 |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44905.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1033.1 | |
| All* | Total formula weight | 45938.8 |
