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3CV9

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Cytochrome P450-SU1polymer41244905.61UniProt (P18326)
Pfam (PF00067)
Streptomyces griseolusP450-CVA1, CYP105A1
2B
(A)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.51Chemie (HEM)
3C
(A)
5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOLnon-polymer416.61Chemie (VDX)
4D
(A)
waterwater18.0463Chemie (HOH)
Sequence modifications
A: 1 - 406 (UniProt: P18326)
PDBExternal DatabaseDetails
Ala 73Arg 73engineered mutation
Ala 84Arg 84engineered mutation
Gln 308His 308SEE REMARK 999
His 407-expression tag
His 408-expression tag
His 409-expression tag
His 410-expression tag
His 411-expression tag
His 412-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight44905.6
Non-Polymers*Number of molecules2
Total formula weight1033.1
All*Total formula weight45938.8
*Water molecules are not included.

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PDB entries from 2024-11-06

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