3D6N

Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase

Summary for 3D6N

Related1xrt 1xrf
DescriptorDihydroorotase, Aspartate carbamoyltransferase, ZINC ION, ... (5 entities in total)
Functional Keywordsreactor, chamber, pores, internal cavity, hydrolase, metal-binding, pyrimidine biosynthesis, transferase, hydrolase-transferase complex, hydrolase/transferase
Biological sourceAquifex aeolicus
Total number of polymer chains2
Total molecular weight80490.88
Authors
Edwards, B.F.P. (deposition date: 2008-05-20, release date: 2009-01-20, Last modification date: 2011-07-13)
Primary citation
Zhang, P.,Martin, P.D.,Purcarea, C.,Vaishnav, A.,Brunzelle, J.S.,Fernando, R.,Guy-Evans, H.I.,Evans, D.R.,Edwards, B.F.
Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Biochemistry, 48:766-778, 2009
PubMed: 19128030 (PDB entries with the same primary citation)
DOI: 10.1021/bi801831r
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20260.7%4.0%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3d6n
no rotation
Molmil generated image of 3d6n
rotated about x axis by 90°
Molmil generated image of 3d6n
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3d6n
no rotation
Molmil generated image of 3d6n
rotated about x axis by 90°
Molmil generated image of 3d6n
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3d6n.pdb2.gz [123.59 KB])
Coordinate files for Biological unit (3d6n.pdb1.gz [723.4 KB])