4B9W
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![BU of 4b9w by Molmil](/molmil-images/mine/4b9w) | Structure of extended Tudor domain TD3 from mouse TDRD1 in complex with MILI peptide containing dimethylarginine 45. | Descriptor: | GLYCEROL, PIWI-LIKE PROTEIN 2, TUDOR DOMAIN-CONTAINING PROTEIN 1 | Authors: | Mathioudakis, N, Palencia, A, Kadlec, J, Round, A, Tripsianes, K, Sattler, M, Pillai, R.S, Cusack, S. | Deposit date: | 2012-09-08 | Release date: | 2012-10-17 | Last modified: | 2019-04-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. Rna, 18, 2012
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4B3E
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![BU of 4b3e by Molmil](/molmil-images/mine/4b3e) | Structure of copper-zinc superoxide dismutase complexed with bicarbonate. | Descriptor: | CARBONATE ION, COPPER (II) ION, SULFATE ION, ... | Authors: | Strange, R.W, Hough, M.A, Antonyuk, S.V, Hasnain, S.S. | Deposit date: | 2012-07-23 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase. Plos One, 7, 2012
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4B75
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![BU of 4b75 by Molmil](/molmil-images/mine/4b75) | Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function | Descriptor: | (2S)-4-amino-N-[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propyl]-4-oxobutan-2-aminium, NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 | Authors: | Saalau-Bethell, S.M, Woodhead, A.J, Chessari, G, Carr, M.G, Coyle, J, Graham, B, Hiscock, S.D, Murray, C.W, Pathuri, P, Rich, S.J, Richardson, C.J, Williams, P.A, Jhoti, H. | Deposit date: | 2012-08-16 | Release date: | 2012-10-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Discovery of an Allosteric Mechanism for the Regulation of Hcv Ns3 Protein Function. Nat.Chem.Biol., 8, 2012
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4BC4
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![BU of 4bc4 by Molmil](/molmil-images/mine/4bc4) | Crystal structure of human D-xylulokinase in complex with D-xylulose | Descriptor: | 1,2-ETHANEDIOL, D-XYLULOSE, XYLULOSE KINASE | Authors: | Bunker, R.D, Loomes, K.M, Baker, E.N. | Deposit date: | 2012-10-01 | Release date: | 2012-11-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure and Function of Human Xylulokinase, an Enzyme with Important Roles in Carbohydrate Metabolism J.Biol.Chem., 288, 2013
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417D
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![BU of 417d by Molmil](/molmil-images/mine/417d) | A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE | Descriptor: | DNA (5'-D(*CP*AP*CP*GP*(C46)P*G)-3') | Authors: | Lin, P.K.T, Schuerman, M.H, Moore, G.S, Van Meervelt, L, Loakes, D, Brown, D.M, Moore, M.H. | Deposit date: | 1998-07-15 | Release date: | 1998-09-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex. J.Mol.Biol., 282, 1998
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4A7V
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![BU of 4a7v by Molmil](/molmil-images/mine/4a7v) | Structure of human I113T SOD1 mutant complexed with dopamine in the p21 space group | Descriptor: | COPPER (II) ION, L-DOPAMINE, SULFATE ION, ... | Authors: | Wright, G.S.A, Antonyuk, S.V, Kershaw, N.M, Strange, R.W, Hasnain, S.S. | Deposit date: | 2011-11-14 | Release date: | 2012-11-28 | Last modified: | 2013-05-08 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Ligand Binding and Aggregation of Pathogenic Sod1. Nat.Commun., 4, 2013
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4A3B
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![BU of 4a3b by Molmil](/molmil-images/mine/4a3b) | RNA Polymerase II initial transcribing complex with a 4nt DNA-RNA hybrid | Descriptor: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | Authors: | Cheung, A.C.M, Sainsbury, S, Cramer, P. | Deposit date: | 2011-09-30 | Release date: | 2011-12-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
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4A4E
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![BU of 4a4e by Molmil](/molmil-images/mine/4a4e) | Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine | Descriptor: | N3, N4-DIMETHYLARGININE, SURVIVAL MOTOR NEURON PROTEIN | Authors: | Tripsianes, K, Madl, T, Machyna, M, Fessas, D, Englbrecht, C, Fischer, U, Neugebauer, K.M, Sattler, M. | Deposit date: | 2011-10-12 | Release date: | 2011-11-30 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural Basis for Dimethyl-Arginine Recognition by the Tudor Domains of Human Smn and Spf30 Proteins Nat.Struct.Mol.Biol., 18, 2011
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4A53
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![BU of 4a53 by Molmil](/molmil-images/mine/4a53) | Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6 | Descriptor: | EDC3 | Authors: | Fromm, S.A, Truffault, V, Kamenz, J, Braun, J.E, Hoffmann, N.A, Izaurralde, E, Sprangers, R. | Deposit date: | 2011-10-24 | Release date: | 2012-02-01 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex. Embo J., 31, 2011
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4APD
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![BU of 4apd by Molmil](/molmil-images/mine/4apd) | Liraglutide | Descriptor: | LIRAGLUTIDE, N-hexadecanoyl-L-glutamic acid | Authors: | Ludvigsen, S, Steensgaard, D.B, Thomsen, J.K, Strauss, H, Normann, M. | Deposit date: | 2012-04-02 | Release date: | 2013-07-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Liraglutide To be Published
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4A4H
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![BU of 4a4h by Molmil](/molmil-images/mine/4a4h) | Solution structure of SPF30 Tudor domain in complex with asymmetrically dimethylated arginine | Descriptor: | NG,NG-DIMETHYL-L-ARGININE, SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30 | Authors: | Tripsianes, K, Madl, T, Machyna, M, Fessas, D, Englbrecht, C, Fischer, U, Neugebauer, K.M, Sattler, M. | Deposit date: | 2011-10-12 | Release date: | 2011-11-30 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis for Dimethyl-Arginine Recognition by the Tudor Domains of Human Smn and Spf30 Proteins Nat.Struct.Mol.Biol., 18, 2011
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4A86
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![BU of 4a86 by Molmil](/molmil-images/mine/4a86) | |
4A7D
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![BU of 4a7d by Molmil](/molmil-images/mine/4a7d) | X-ray crystal structure of HEWL flash-cooled at high pressure | Descriptor: | CHLORIDE ION, LYSOZYME C, SODIUM ION | Authors: | Burkhardt, A, Warmer, M, Panneerselvam, S, Wagner, A, Reimer, R, Hohenberg, H, Meents, A. | Deposit date: | 2011-11-14 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.497 Å) | Cite: | Fast High-Pressure Freezing of Protein Crystals in Their Mother Liquor Acta Crystallogr.,Sect.F, 68, 2012
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4A84
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![BU of 4a84 by Molmil](/molmil-images/mine/4a84) | Crystal Structure of Major Birch Pollen Allergen Bet v 1 a F30V mutant in complex with deoxycholate. | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A, ... | Authors: | Kofler, S, Brandstetter, H. | Deposit date: | 2011-11-18 | Release date: | 2012-05-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystallographically Mapped Ligand Binding Differs in High and Low Ige Binding Isoforms of Birch Pollen Allergen Bet V 1. J.Mol.Biol., 422, 2012
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4B73
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![BU of 4b73 by Molmil](/molmil-images/mine/4b73) | Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function | Descriptor: | (2S)-4-amino-N-[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propyl]-4-oxobutan-2-aminium, NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 | Authors: | Saalau-Bethell, S.M, Woodhead, A.J, Chessari, G, Carr, M.G, Coyle, J, Graham, B, Hiscock, S.D, Murray, C.W, Pathuri, P, Rich, S.J, Richardson, C.J, Williams, P.A, Jhoti, H. | Deposit date: | 2012-08-16 | Release date: | 2012-10-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of an Allosteric Mechanism for the Regulation of Hcv Ns3 Protein Function. Nat.Chem.Biol., 8, 2012
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4BC5
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![BU of 4bc5 by Molmil](/molmil-images/mine/4bc5) | Crystal structure of human D-xylulokinase in complex with inhibitor 5- deoxy-5-fluoro-D-xylulose | Descriptor: | 1,2-ETHANEDIOL, 5-deoxy-5-fluoro-D-xylulose, XYLULOSE KINASE | Authors: | Bunker, R.D, Loomes, K.M, Baker, E.N. | Deposit date: | 2012-10-01 | Release date: | 2012-11-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structure and Function of Human Xylulokinase, an Enzyme with Important Roles in Carbohydrate Metabolism J.Biol.Chem., 288, 2013
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4A7F
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![BU of 4a7f by Molmil](/molmil-images/mine/4a7f) | Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 3) | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Behrmann, E, Mueller, M, Penczek, P.A, Mannherz, H.G, Manstein, D.J, Raunser, S. | Deposit date: | 2011-11-14 | Release date: | 2012-08-01 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structure of the Rigor Actin-Tropomyosin-Myosin Complex. Cell(Cambridge,Mass.), 150, 2012
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4A93
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![BU of 4a93 by Molmil](/molmil-images/mine/4a93) | RNA Polymerase II elongation complex containing a CPD Lesion | Descriptor: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*T*TTP*TP*TP*CP*C BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP*AP)-3', ... | Authors: | Walmacq, C, Cheung, A.C.M, Kireeva, M.L, Lubkowska, L, Ye, C, Gotte, D, Strathern, J.N, Carell, T, Cramer, P, Kashlev, M. | Deposit date: | 2011-11-23 | Release date: | 2012-03-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Mechanism of Translesion Transcription by RNA Polymerase II and its Role in Cellular Resistance to DNA Damage. Mol.Cell, 46, 2012
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4AOJ
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![BU of 4aoj by Molmil](/molmil-images/mine/4aoj) | Human TrkA in complex with the inhibitor AZ-23 | Descriptor: | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION | Authors: | Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H. | Deposit date: | 2012-03-28 | Release date: | 2012-08-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors Acs Med.Chem.Lett., 3, 2012
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4AQ5
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![BU of 4aq5 by Molmil](/molmil-images/mine/4aq5) | |
4A4G
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![BU of 4a4g by Molmil](/molmil-images/mine/4a4g) | Solution structure of SMN Tudor domain in complex with asymmetrically dimethylated arginine | Descriptor: | NG,NG-DIMETHYL-L-ARGININE, SURVIVAL MOTOR NEURON PROTEIN | Authors: | Tripsianes, K, Madl, T, Machyna, M, Fessas, D, Englbrecht, C, Fischer, U, Neugebauer, K.M, Sattler, M. | Deposit date: | 2011-10-12 | Release date: | 2011-11-30 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis for Dimethyl-Arginine Recognition by the Tudor Domains of Human Smn and Spf30 Proteins Nat.Struct.Mol.Biol., 18, 2011
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430D
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![BU of 430d by Molmil](/molmil-images/mine/430d) | STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA | Descriptor: | MAGNESIUM ION, SARCIN/RICIN LOOP FROM RAT 28S R-RNA | Authors: | Correll, C.C, Munishkin, A, Chan, Y.L, Ren, Z, Wool, I.G, Steitz, T.A. | Deposit date: | 1998-10-04 | Release date: | 1998-10-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the ribosomal RNA domain essential for binding elongation factors. Proc.Natl.Acad.Sci.USA, 95, 1998
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4A8A
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![BU of 4a8a by Molmil](/molmil-images/mine/4a8a) | Asymmetric cryo-EM reconstruction of E. coli DegQ 12-mer in complex with lysozyme | Descriptor: | LYSOZYME C, PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | Authors: | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | Deposit date: | 2011-11-20 | Release date: | 2011-12-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (14.2 Å) | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq Nat.Struct.Mol.Biol., 19, 2012
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4A83
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![BU of 4a83 by Molmil](/molmil-images/mine/4a83) | Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in complex with deoxycholate. | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A, ... | Authors: | Kofler, S, Brandstetter, H. | Deposit date: | 2011-11-18 | Release date: | 2012-05-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Crystallographically Mapped Ligand Binding Differs in High and Low Ige Binding Isoforms of Birch Pollen Allergen Bet V 1. J.Mol.Biol., 422, 2012
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4A7L
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![BU of 4a7l by Molmil](/molmil-images/mine/4a7l) | Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 1) | Descriptor: | ACTIN, ALPHA SKELETON MUSCLE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Behrmann, E, Mueller, M, Penczek, P.A, Mannherz, H.G, Manstein, D.J, Raunser, S. | Deposit date: | 2011-11-14 | Release date: | 2012-08-01 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structure of the Rigor Actin-Tropomyosin-Myosin Complex. Cell(Cambridge,Mass.), 150, 2012
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