5GAJ
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![BU of 5gaj by Molmil](/molmil-images/mine/5gaj) | Solution NMR structure of De novo designed PLOOP2X3_50 fold protein, Northeast Structural Genomics Consortium (NESG) target OR258 | Descriptor: | DE NOVO DESIGNED PROTEIN OR258 | Authors: | Liu, G, Castelllanos, J, Koga, R, Koga, N, Xiao, R, Pederson, K, Janjua, H, Kohan, E, Acton, T.B, Kornhaber, G, Everett, J, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-12-01 | Release date: | 2016-01-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure De novo designed PLOOP2X3_50 fold protein, Northeast Structural Genomics Consortium (NESG) target OR258 To Be Published
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6ZV9
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![BU of 6zv9 by Molmil](/molmil-images/mine/6zv9) | Terbium(III)-bound de novo TIM barrel-ferredoxin fold fusion dimer with 4-glutamate binding site and tryptophan antenna (TFD-EE N6W) | Descriptor: | 1,2-ETHANEDIOL, TERBIUM(III) ION, TFD-EE | Authors: | Caldwell, S, Haydon, I, Piperidou, N, Huang, P, Hilvert, D, Baker, D, Zeymer, C. | Deposit date: | 2020-07-24 | Release date: | 2020-11-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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8R8N
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![BU of 8r8n by Molmil](/molmil-images/mine/8r8n) | |
8R8O
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![BU of 8r8o by Molmil](/molmil-images/mine/8r8o) | Hallucinated de novo TIM barrel with three helical extensions - HalluTIM3-1 | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Beck, J, Shanmugaratnam, S, Hocker, B. | Deposit date: | 2023-11-29 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Diversifying de novo TIM barrels by hallucination. Protein Sci., 33, 2024
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7A8S
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![BU of 7a8s by Molmil](/molmil-images/mine/7a8s) | de novo designed ba8-barrel sTIM11 with an alpha-helical extension | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, sTIM11_h3 | Authors: | Shanmugaratnam, S, Wiese, J.G, Hocker, B. | Deposit date: | 2020-08-31 | Release date: | 2021-03-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Extension of a de novo TIM barrel with a rationally designed secondary structure element. Protein Sci., 30, 2021
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6ZT1
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![BU of 6zt1 by Molmil](/molmil-images/mine/6zt1) | |
7TJL
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![BU of 7tjl by Molmil](/molmil-images/mine/7tjl) | |
2MTQ
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![BU of 2mtq by Molmil](/molmil-images/mine/2mtq) | Solution Structure of a De Novo Designed Peptide that Sequesters Toxic Heavy Metals | Descriptor: | Designed Peptide | Authors: | Plegaria, J.S, Zuiderweg, E.R, Stemmler, T.L, Pecoraro, V.L. | Deposit date: | 2014-08-28 | Release date: | 2015-04-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Apoprotein Structure and Metal Binding Characterization of a de Novo Designed Peptide, alpha 3DIV, that Sequesters Toxic Heavy Metals. Biochemistry, 54, 2015
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3P6J
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![BU of 3p6j by Molmil](/molmil-images/mine/3p6j) | |
2MQ8
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![BU of 2mq8 by Molmil](/molmil-images/mine/2mq8) | Solution NMR Structure of De novo designed protein LFR1 1 with ferredoxin fold, Northeast Structural Genomics Consortium (NESG) Target OR414 | Descriptor: | De novo designed protein LFR1 | Authors: | Liu, G, Lin, Y, Koga, N, Koga, R, Xiao, R, Janjua, H, Pederson, K, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-06-12 | Release date: | 2014-08-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Control over overall shape and size in de novo designed proteins. Proc.Natl.Acad.Sci.USA, 112, 2015
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2MR5
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![BU of 2mr5 by Molmil](/molmil-images/mine/2mr5) | Solution NMR Structure of De novo designed Protein, Northeast Structural Genomics Consortium (NESG) Target OR457 | Descriptor: | De novo designed Protein OR457 | Authors: | Pulavarti, S, Nivon, L, Maglaqui, M, Janjua, H, Mao, L, Xiao, R, Kornhaber, G, Baker, D, Montelione, G, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-07-01 | Release date: | 2014-09-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed Protein, Northeast Structural Genomics Consortium (NESG) Target OR457 To be Published
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8AH9
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![BU of 8ah9 by Molmil](/molmil-images/mine/8ah9) | |
2N76
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![BU of 2n76 by Molmil](/molmil-images/mine/2n76) | Solution NMR Structure of De novo designed protein LFR1 1 with ferredoxin fold, Northeast Structural Genomics Consortium (NESG) Target OR414 | Descriptor: | De novo designed protein LFR1 | Authors: | Liu, G, Lin, Y, Koga, N, Koga, R, Xiao, R, Janjua, H, Pederson, K, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-09-03 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed protein LFR1 1 with ferredoxin fold, Northeast Structural Genomics Consortium (NESG) Target OR414 To be Published
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2MRA
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![BU of 2mra by Molmil](/molmil-images/mine/2mra) | Solution NMR Structure of De novo designed protein, Northeast Structural Genomics Consortium (NESG) Target OR459 | Descriptor: | De novo designed protein OR459 | Authors: | Pulavarti, S.V.S.R.K, Kipnis, Y, Sukumaran, D, Maglaqui, M, Janjua, H, Mao, L, Xiao, R, Kornhaber, G, Baker, D, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-07-02 | Release date: | 2014-09-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed protein, Northeast Structural Genomics Consortium (NESG) Target OR459 To be Published
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2MTL
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![BU of 2mtl by Molmil](/molmil-images/mine/2mtl) | Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109 | Descriptor: | De novo designed protein FR55 OR109 | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Hamilton, K, Ciccosanti, C, Sahdev, S, Kohan, E, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-08-19 | Release date: | 2014-10-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109 To be Published
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2LRH
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![BU of 2lrh by Molmil](/molmil-images/mine/2lrh) | Solution NMR structure of de novo designed protein, p-loop ntpase fold, Northeast Structural Genomics Consortium target or137 | Descriptor: | De novo designed protein | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-03-30 | Release date: | 2012-07-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of de novo designed protein, p-loop ntpase fold, Northeast Structural Genomics Consortium target or137 To be Published
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8BL3
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![BU of 8bl3 by Molmil](/molmil-images/mine/8bl3) | |
8BL6
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![BU of 8bl6 by Molmil](/molmil-images/mine/8bl6) | |
2N75
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![BU of 2n75 by Molmil](/molmil-images/mine/2n75) | Solution NMR Structure of De novo designed protein, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446 | Descriptor: | De novo designed protein | Authors: | Liu, G, Lin, Y, Koga, N, Koga, R, Xiao, R, Janjua, H, Pederson, K, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-09-03 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed protein, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446 To be Published
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2MR6
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![BU of 2mr6 by Molmil](/molmil-images/mine/2mr6) | Solution NMR Structure of De novo designed protein, Northeast Structural Genomics Consortium (NESG) Target OR462 | Descriptor: | De novo designed Protein OR462 | Authors: | Xu, X, Nivon, L, Federizon, J.F, Maglaqui, M, Janjua, H, Mao, L, Xiao, R, Kornhaber, G, Baker, D, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-07-01 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed protein, Northeast Structural Genomics Consortium (NESG) Target OR462 To be Published
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5J9F
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![BU of 5j9f by Molmil](/molmil-images/mine/5j9f) | Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183) | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | Authors: | Wong, J, Deis, S.M, Dann III, C.E. | Deposit date: | 2016-04-09 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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8CCR
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![BU of 8ccr by Molmil](/molmil-images/mine/8ccr) | |
6EGC
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![BU of 6egc by Molmil](/molmil-images/mine/6egc) | |
1L4X
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![BU of 1l4x by Molmil](/molmil-images/mine/1l4x) | Octameric de novo designed peptide | Descriptor: | CHLORIDE ION, MAGNESIUM ION, SIN-ASP-GLU-LEU-GLU-ARG-ALA-ILE-ARG-GLU-LEU-ALA-ALA-ARG-ILE-LYS-NH2 | Authors: | Meier, M, Lustig, A, Aebi, U, Burkhard, P. | Deposit date: | 2002-03-06 | Release date: | 2002-11-13 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Removing an interhelical salt bridge abolishes coiled-coil formation in a de novo designed peptide J.STRUCT.BIOL., 137, 2002
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7OSU
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![BU of 7osu by Molmil](/molmil-images/mine/7osu) | sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 1) | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Romero-Romero, S, Kordes, S, Hocker, B. | Deposit date: | 2021-06-09 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
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