6D5M
 
 | | Ras:SOS:Ras in complex with a small molecule activator | | Descriptor: | 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1H-benzimidazole, GTPase HRas, MAGNESIUM ION, ... | | Authors: | Phan, J, Hodges, T, Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.081 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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7MSO
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7R1W
 | | E. coli BAM complex (BamABCDE) bound to dynobactin A | | Descriptor: | Dynobactin A, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | | Authors: | Jakob, R.P, Hiller, S, Maier, T. | | Deposit date: | 2022-02-03 | | Release date: | 2022-09-28 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Computational identification of a systemic antibiotic for gram-negative bacteria.
Nat Microbiol, 7, 2022
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7R1V
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6RBC
 | | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a inhibitor KB1157 | | Descriptor: | (2~{S})-2-[[(2~{R})-2-[4-[(4-iodophenyl)carbonylamino]butanoylamino]-3-oxidanyl-3-oxidanylidene-propyl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Barinka, C, Kutil, Z. | | Deposit date: | 2019-04-10 | | Release date: | 2020-05-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen.
J.Med.Chem., 63, 2020
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6S1X
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2BD0
 | | Chlorobium tepidum Sepiapterin Reductase complexed with NADP and Sepiapterin | | Descriptor: | BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, sepiapterin reductase | | Authors: | Supangat, S, Seo, K.H, Choi, Y.K, Park, Y.S, Lee, K.H. | | Deposit date: | 2005-10-19 | | Release date: | 2005-11-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
J.Biol.Chem., 281, 2006
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2ESB
 | | Crystal structure of human DUSP18 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Dual specificity protein phosphatase 18 | | Authors: | Kim, S.J, Ryu, S.E, Jeong, D.G, Cho, Y.H, Yoon, T.S, Kim, J.H. | | Deposit date: | 2005-10-25 | | Release date: | 2006-06-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.
Acta Crystallogr.,Sect.D, 62, 2006
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8Q6P
 | | X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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8Q6O
 | | X. laevis CMG dimer bound to dimeric DONSON - without ATPase | | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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7ETX
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7ETY
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6V9N
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6V94
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6V9J
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5ITS
 | | Crystal structure of LOG from Corynebacterium glutamicum | | Descriptor: | Cytokinin riboside 5'-monophosphate phosphoribohydrolase, GLYCEROL, PHOSPHATE ION | | Authors: | Seo, H.-G, Kim, K.-J. | | Deposit date: | 2016-03-17 | | Release date: | 2016-08-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for cytokinin production by LOG from Corynebacterium glutamicum
Sci Rep, 6, 2016
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6V9M
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6V9F
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6V9L
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4N45
 | | Crystal structure of reduced form of thiolase from Clostridium acetobutylicum | | Descriptor: | Acetyl-CoA acetyltransferase | | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | | Deposit date: | 2013-10-08 | | Release date: | 2014-10-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural insight into redox-switch regulatory mechanism of thiolase from the n-butanol synthesizing bacterium, Clostridium acetobutylicum
to be published
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4N44
 | | Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum | | Descriptor: | ACETATE ION, Acetyl-CoA acetyltransferase, GLYCEROL | | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | | Deposit date: | 2013-10-08 | | Release date: | 2014-10-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structural insight into redox-switch regulatory mechanism of thiolase from the n-butanol synthesizing bacterium, Clostridium acetobutylicum
to be published
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5JXD
 | | Crystal structure of murine Tnfaip8 C165S mutant | | Descriptor: | Tumor necrosis factor alpha-induced protein 8, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | Authors: | Park, J, Kim, M.S, Lee, D, Shin, D.H. | | Deposit date: | 2016-05-13 | | Release date: | 2017-06-28 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.029 Å) | | Cite: | The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Sci Rep, 7, 2017
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4NYM
 | | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | | Descriptor: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]-L-tryptophanamide, ... | | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.5529 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYJ
 | | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | | Descriptor: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... | | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8522 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYI
 | | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | | Descriptor: | GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... | | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9612 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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