PDB: 97310 resultsInfo pagesStatus searchChemie searchBIRD

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7XHY	Crystal structure of MerTK Kinase domain with BMS794833 Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, Tyrosine-protein kinase Mer, ... Authors: Kim, J.H, Lee, B.I. Deposit date: 2022-04-11 Release date: 2022-11-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.16 Å) Cite: BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity. Exp.Mol.Med., 54, 2022
7XO2	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-04-30 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
7XO1	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-04-30 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8GM6	Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Selenomethionine) Descriptor: GLYCEROL, SULFATE ION, TK0353 Authors: Eckenroth, B.E, Gardner, A.F, Doublie, S. Deposit date: 2023-03-24 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
8GM7	Structure of apurinic/apyrimidinic DNA Lyase TK0353 from Thermococcus kodakarensis (Native Crystal Form) Descriptor: GLYCEROL, SULFATE ION, TK0353 Authors: Eckenroth, B.E, Gardner, A.F, Doublie, S. Deposit date: 2023-03-24 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
6NAD	Identification and biological evaluation of tertiary ALCOHOL-based inverse agonists of RORgt Descriptor: (S)-(4-chloro-2-methoxy-3-{[4-(trifluoromethyl)piperidin-1-yl]methyl}quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)[2-(trifluoromethyl)pyridin-4-yl]methanol, Nuclear receptor ROR-gamma Authors: Spurlino, J, Milligan, C. Deposit date: 2018-12-05 Release date: 2019-05-08 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.90197086 Å) Cite: 3-Substituted Quinolines as ROR gamma t Inverse Agonists. Bioorg.Med.Chem.Lett., 29, 2019
7TTZ	Heterodimeric IgA Fc in complex with Staphylococcus aureus protein SSL7 Descriptor: 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Boulanger, M.J, Verstraete, M, Heinkel, F, Escobar, E, Dixit, S, Von Kreudenstein, T.S. Deposit date: 2022-02-02 Release date: 2023-02-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics. Mabs, 14, 2022
7DWM	Crystal structure of the phage VqmA-DPO complex Descriptor: 3,5-dimethylpyrazin-2-ol, Transcriptional regulator Authors: Gu, Y, Yang, W.S. Deposit date: 2021-01-17 Release date: 2021-05-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Understanding the mechanism of asymmetric gene regulation determined by the VqmA of vibriophage. Biochem.Biophys.Res.Commun., 558, 2021
7U9E	Pfs230 D1 domain in complex with 230AL-26 Descriptor: 230AL-26, Gametocyte surface protein P230, LMIV230-01 Authors: Tang, W.K, Tolia, N.H. Deposit date: 2022-03-10 Release date: 2023-02-15 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.39 Å) Cite: A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine. Immunity, 56, 2023
5VGY	Identification of a New Zinc Binding Chemotype by Fragment Screening Descriptor: (5S)-5-[(2,4-dimethoxyphenyl)methyl]-5-hydroxy-2-sulfanylideneimidazolidin-4-one, Carbonic anhydrase 2, SODIUM ION, ... Authors: Peat, T.S. Deposit date: 2017-04-11 Release date: 2017-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
7WDA	Crystal structure LpqY in complex with Trehalose from Mycobacterium tuberculosis Descriptor: SULFATE ION, Trehalose-binding lipoprotein LpqY, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose Authors: Sharma, D, Das, U. Deposit date: 2021-12-21 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Acta Crystallogr D Struct Biol, 78, 2022
7WCJ	Crystal structure LpqY from Mycobacterium tuberculosis Descriptor: SULFATE ION, Trehalose-binding lipoprotein LpqY Authors: Sharma, D, Das, U. Deposit date: 2021-12-20 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Acta Crystallogr D Struct Biol, 78, 2022
7DA0	High-resolution crystal structure of the chicken MHF complex Descriptor: Centromere protein S, Centromere protein X Authors: Ito, S, Nishino, T. Deposit date: 2020-10-14 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7NY4	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-130 Descriptor: 14-3-3 protein sigma, 4-(3-oxidanylidenepiperazin-1-yl)sulfonylbenzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-20 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7DA1	Crystal structure of the chicken MHF complex Descriptor: Centromere protein S, Centromere protein X Authors: Ito, S, Nishino, T. Deposit date: 2020-10-14 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7DA2	The crystal structure of the chicken FANCM-MHF complex Descriptor: Centromere protein S, Centromere protein X, Fanconi anemia group M protein Authors: Nishino, T, Ito, S. Deposit date: 2020-10-14 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7U0R	Crystal structure of Methanomethylophilus alvus PylRS(N166A/V168A) complexed with meta-trifluoromethyl-2-benzylmalonate and AMP-PNP Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Swenson, C.V, Roe, L.T, Fricke, R.C.B, Smaga, S.S, Gee, C.L, Schepartz, A. Deposit date: 2022-02-18 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-alpha-amino acids in vitro and in vivo. Nat.Chem., 15, 2023
6NIT	Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4) Descriptor: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-12-31 Release date: 2019-08-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
8GMH	Crystal Structure of the ternary complex of TelA-LXG, LapA3, and LapA4 Descriptor: 1,2-ETHANEDIOL, LXG domain-containing protein, LapA3, ... Authors: Klein, T.A, Shah, P.Y, Gkragkopoulou, P, Grebenc, D.W, Kim, Y, Whitney, J.C. Deposit date: 2023-03-25 Release date: 2024-01-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of a tripartite protein complex that targets toxins to the type VII secretion system. Proc.Natl.Acad.Sci.USA, 121, 2024
7S11	Crystal structure of Fab in complex with mouse CD96 monomer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... Authors: Lee, P.S, Chau, B, Strop, P. Deposit date: 2021-08-31 Release date: 2021-11-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Antibody blockade of CD96 by distinct molecular mechanisms. Mabs, 13, 2021
5FQS	Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3. Descriptor: (E)-3-[4-(6-HYDROXY-2-ISOBUTYL-1-METHYL-3,4-DIHYDROISOQUINOLIN-1-YL)PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR Authors: Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. Deposit date: 2015-12-14 Release date: 2016-02-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
5G4P	Crystal structure of human hippocalcin at 2.4 A resolution Descriptor: CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin Authors: Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. Deposit date: 2016-05-15 Release date: 2017-05-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
8GA6	Geometrically programmable nanomaterial construction using regularized protein building blocks Descriptor: THR6 Authors: Huddy, T, Bera, A.K, Baker, D, Kang, A. Deposit date: 2023-02-22 Release date: 2024-03-13 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
5G58	Crystal structure of A190T mutant of human hippocalcin AT 2.5 A resolution Descriptor: CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin Authors: Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. Deposit date: 2016-05-22 Release date: 2017-05-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. Deposit date: 2016-07-01 Release date: 2016-08-17 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016

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