7XHY

Crystal structure of MerTK Kinase domain with BMS794833

Summary for 7XHY

• Entry DOI: 10.2210/pdb7xhy/pdb
• Descriptor: Tyrosine-protein kinase Mer, ~{N}-[4-(2-azanyl-3-chloranyl-pyridin-4-yl)oxy-3-fluoranyl-phenyl]-5-(4-fluorophenyl)-4-oxidanylidene-1~{H}-pyridine-3-carboxamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: atp competitive inhibitor mertk-bms794833 complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35070.54

Authors

Kim, J.H.,Lee, B.I. (deposition date: 2022-04-11, release date: 2022-11-30, Last modification date: 2023-11-29)

• Primary citation: Bae, S.H.,Kim, J.H.,Park, T.H.,Lee, K.,Lee, B.I.,Jang, H.; BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity.; Exp.Mol.Med., 54:1450-1460, 2022; PubMed: 36056187; DOI: 10.1038/s12276-022-00840-x

Experimental method

X-RAY DIFFRACTION (2.16 Å)