7F0C
| Crystal structure of capreomycin phosphotransferase in complex with CMN IIA | Descriptor: | Capreomycin phosphotransferase, DPP-SER-DPP-UAL-MYN-KBE | Authors: | Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. | Deposit date: | 2021-06-03 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
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5M2K
| Crystal structure of vancomycin-Zn(II) complex | Descriptor: | 1,2-ETHANEDIOL, ZINC ION, vancomycin, ... | Authors: | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | Deposit date: | 2016-10-13 | Release date: | 2017-07-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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5M2H
| Crystal structure of vancomycin-Zn(II)-citrate complex | Descriptor: | CITRIC ACID, HEXAETHYLENE GLYCOL, Vancomycin, ... | Authors: | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | Deposit date: | 2016-10-13 | Release date: | 2017-07-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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4XVZ
| MycF mycinamicin III 3'-O-methyltransferase in complex with Mg | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Mycinamicin III 3''-O-methyltransferase | Authors: | Akey, D.L, Smith, J.L. | Deposit date: | 2015-01-28 | Release date: | 2015-03-04 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10, 2015
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4XVY
| MycF mycinamicin III 3'-O-methyltransferase in complex with SAH | Descriptor: | MAGNESIUM ION, Mycinamicin III 3''-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Akey, D.L, Smith, J.L. | Deposit date: | 2015-01-28 | Release date: | 2015-03-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10, 2015
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5JVG
| The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 50S ribosomal protein L11, ... | Authors: | Krupkin, M, Wekselman, I, Matzov, D, Eyal, Z, Diskin Posner, Y, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2016-05-11 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.428 Å) | Cite: | Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc.Natl.Acad.Sci.USA, 113, 2016
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6F74
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6F73
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6F72
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4X7Y
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4X7X
| MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and macrocin | Descriptor: | 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-4-(dimethylamino)-5-[(2S,4R,5S,6S)-4,6-dimethyl-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-3-oxidanyl-oxan-2-yl]oxy-16-ethyl-15-[[(2R,3R,4R,5S,6R)-3-methoxy-6-methyl-4,5-bis(oxidanyl)oxan-2-yl]oxymethyl]-5,9,13-trimethyl-4-oxidanyl-2,10-bis(oxidanylidene)-1-oxacyclohexadeca-11,13-dien-7-yl]ethanal, MAGNESIUM ION, Mycinamicin III 3''-O-methyltransferase, ... | Authors: | Bernard, S.M, Smith, J.L. | Deposit date: | 2014-12-09 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10, 2015
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1ES4
| C98N mutant of streptomyces K15 DD-transpeptidase | Descriptor: | DD-TRANSPEPTIDASE | Authors: | Fonze, E, Charlier, P. | Deposit date: | 2000-04-07 | Release date: | 2000-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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6BW5
| Human GPT (DPAGT1) in complex with tunicamycin | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | Authors: | Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y. | Deposit date: | 2017-12-14 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat. Struct. Mol. Biol., 25, 2018
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4C7G
| Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2) | Descriptor: | 1,2-ETHANEDIOL, 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, BETA-N-ACETYLHEXOSAMINIDASE | Authors: | Nguyenthi, N, Offen, W.A, Davies, G.J, Doucet, N. | Deposit date: | 2013-09-20 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Activity of the Streptomyces Coelicolor A3(2) Beta-N-Acetylhexosaminidase Provides Further Insight Into Gh20 Family Catalysis and Inhibition. Biochemistry, 53, 2014
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6BW6
| Human GPT (DPAGT1) H129 variant in complex with tunicamycin | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | Authors: | Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y. | Deposit date: | 2017-12-14 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat. Struct. Mol. Biol., 25, 2018
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1ES3
| C98A mutant of streptomyces K15 DD-transpeptidase | Descriptor: | DD-TRANSPEPTIDASE, SODIUM ION | Authors: | Fonze, E, Charlier, P. | Deposit date: | 2000-04-07 | Release date: | 2000-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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4C7F
| Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2) | Descriptor: | 1,2-ETHANEDIOL, 6-ACETAMIDO-6-DEOXY-CASTANOSPERMINE, BETA-N-ACETYLHEXOSAMINIDASE | Authors: | Nguyen Thi, N, Offen, W.A, Davies, G.J, Doucet, N. | Deposit date: | 2013-09-20 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Activity of the Streptomyces Coelicolor A3(2) Beta-N-Acetylhexosaminidase Provides Further Insight Into Gh20 Family Catalysis and Inhibition. Biochemistry, 53, 2014
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6M5Z
| Catalytic domain of GH30 xylanase C from Talaromyces cellulolyticus | Descriptor: | ACETATE ION, GH30 Xylanase C, GLYCEROL, ... | Authors: | Nakamichi, Y, Watanabe, M, Inoue, H. | Deposit date: | 2020-03-12 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of GH30-7 endoxylanase C from the filamentous fungus Talaromyces cellulolyticus. Acta Crystallogr.,Sect.F, 76, 2020
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1JFX
| Crystal structure of the bacterial lysozyme from Streptomyces coelicolor at 1.65 A resolution | Descriptor: | 1,4-beta-N-Acetylmuramidase M1, CHLORIDE ION | Authors: | Rau, A, Hogg, T, Marquardt, R, Hilgenfeld, R. | Deposit date: | 2001-06-22 | Release date: | 2001-09-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A new lysozyme fold. Crystal structure of the muramidase from Streptomyces coelicolor at 1.65 A resolution. J.Biol.Chem., 276, 2001
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1J9M
| K38H mutant of Streptomyces K15 DD-transpeptidase | Descriptor: | CHLORIDE ION, DD-transpeptidase, SODIUM ION | Authors: | Fonze, E, Rhazi, N, Nguyen-Disteche, M, Charlier, P. | Deposit date: | 2001-05-28 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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4C7D
| Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2) | Descriptor: | 1,2-ETHANEDIOL, BETA-N-ACETYLHEXOSAMINIDASE | Authors: | Nguyenthi, N, Offen, W.A, Davies, G.J, Doucet, N. | Deposit date: | 2013-09-20 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and Activity of the Streptomyces Coelicolor A3(2) Beta-N-Acetylhexosaminidase Provides Further Insight Into Gh20 Family Catalysis and Inhibition. Biochemistry, 53, 2014
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2KER
| alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus | Descriptor: | Alpha-amylase inhibitor Z-2685 | Authors: | Rehm, S, Han, S, Hassani, I, Sokocevic, A, Jonker, H.R.A, Engels, J.W, Schwalbe, H. | Deposit date: | 2009-02-02 | Release date: | 2009-02-17 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158 Chembiochem, 10, 2009
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3A21
| Crystal Structure of Streptomyces avermitilis beta-L-Arabinopyranosidase | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | Authors: | Fujimoto, Z, Ichinose, H, Kaneko, S. | Deposit date: | 2009-04-27 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | A beta-l-Arabinopyranosidase from Streptomyces avermitilis is a novel member of glycoside hydrolase family 27. J.Biol.Chem., 284, 2009
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4HYQ
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1NQ6
| Crystal Structure of the catalytic domain of xylanase A from Streptomyces halstedii JM8 | Descriptor: | MAGNESIUM ION, Xys1 | Authors: | Canals, A, Vega, M.C, Gomis-Ruth, F.X, Santamaria, R.I, Coll, M. | Deposit date: | 2003-01-21 | Release date: | 2004-01-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure of xylanase Xys1delta from Streptomyces halstedii. Acta Crystallogr.,Sect.D, 59, 2003
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