6BW5
Human GPT (DPAGT1) in complex with tunicamycin
Summary for 6BW5
Entry DOI | 10.2210/pdb6bw5/pdb |
Descriptor | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Tunicamycin, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate (3 entities in total) |
Functional Keywords | n-linked glycosylation, endoplasmic reticulum, tunicamycin, natural product, transferase, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 194907.04 |
Authors | Yoo, J.,Kuk, A.C.Y.,Mashalidis, E.H.,Lee, S.-Y. (deposition date: 2017-12-14, release date: 2018-02-21, Last modification date: 2023-10-04) |
Primary citation | Yoo, J.,Mashalidis, E.H.,Kuk, A.C.Y.,Yamamoto, K.,Kaeser, B.,Ichikawa, S.,Lee, S.Y. GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat. Struct. Mol. Biol., 25:217-224, 2018 Cited by PubMed: 29459785DOI: 10.1038/s41594-018-0031-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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