6BW5
Human GPT (DPAGT1) in complex with tunicamycin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003975 | molecular_function | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity |
A | 0003976 | molecular_function | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006047 | biological_process | UDP-N-acetylglucosamine metabolic process |
A | 0006486 | biological_process | protein glycosylation |
A | 0006487 | biological_process | protein N-linked glycosylation |
A | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
A | 0019348 | biological_process | dolichol metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046872 | molecular_function | metal ion binding |
B | 0003975 | molecular_function | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity |
B | 0003976 | molecular_function | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0006047 | biological_process | UDP-N-acetylglucosamine metabolic process |
B | 0006486 | biological_process | protein glycosylation |
B | 0006487 | biological_process | protein N-linked glycosylation |
B | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
B | 0019348 | biological_process | dolichol metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0046872 | molecular_function | metal ion binding |
C | 0003975 | molecular_function | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity |
C | 0003976 | molecular_function | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005789 | cellular_component | endoplasmic reticulum membrane |
C | 0006047 | biological_process | UDP-N-acetylglucosamine metabolic process |
C | 0006486 | biological_process | protein glycosylation |
C | 0006487 | biological_process | protein N-linked glycosylation |
C | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
C | 0019348 | biological_process | dolichol metabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
C | 0046872 | molecular_function | metal ion binding |
D | 0003975 | molecular_function | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity |
D | 0003976 | molecular_function | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005789 | cellular_component | endoplasmic reticulum membrane |
D | 0006047 | biological_process | UDP-N-acetylglucosamine metabolic process |
D | 0006486 | biological_process | protein glycosylation |
D | 0006487 | biological_process | protein N-linked glycosylation |
D | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
D | 0016020 | cellular_component | membrane |
D | 0016740 | molecular_function | transferase activity |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
D | 0019348 | biological_process | dolichol metabolic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue TUM A 501 |
Chain | Residue |
A | GLN44 |
A | ASN185 |
A | ILE186 |
A | ALA188 |
A | GLY189 |
A | ILE190 |
A | ASN191 |
A | ASP252 |
A | PHE286 |
A | HIS302 |
A | ARG303 |
A | ASP45 |
A | ILE304 |
A | LEU46 |
A | GLU56 |
A | ASN119 |
A | TRP122 |
A | LYS125 |
A | LEU126 |
A | ASN182 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue PGW A 502 |
Chain | Residue |
A | CYS107 |
A | PHE110 |
A | LEU111 |
A | ALA114 |
A | HIS124 |
B | ALA64 |
B | ILE68 |
B | PHE71 |
site_id | AC3 |
Number of Residues | 21 |
Details | binding site for residue TUM B 501 |
Chain | Residue |
B | GLN44 |
B | ASP45 |
B | LEU46 |
B | ASN119 |
B | TRP122 |
B | LYS125 |
B | LEU126 |
B | PHE179 |
B | ASN185 |
B | ILE186 |
B | ALA188 |
B | GLY189 |
B | ILE190 |
B | ASN191 |
B | PHE249 |
B | ASP252 |
B | PHE286 |
B | LEU293 |
B | ARG301 |
B | ARG303 |
B | ILE304 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue PGW B 502 |
Chain | Residue |
A | ALA31 |
A | HIS35 |
A | ILE68 |
B | PHE110 |
B | ALA114 |
B | HIS124 |
site_id | AC5 |
Number of Residues | 22 |
Details | binding site for residue TUM C 501 |
Chain | Residue |
C | GLN44 |
C | ASP45 |
C | LEU46 |
C | GLU56 |
C | ASN119 |
C | TRP122 |
C | LYS125 |
C | LEU126 |
C | ASN185 |
C | ILE186 |
C | ALA188 |
C | GLY189 |
C | ILE190 |
C | ASN191 |
C | PHE249 |
C | ASP252 |
C | PHE286 |
C | LEU293 |
C | ARG301 |
C | HIS302 |
C | ARG303 |
C | ILE304 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue PGW C 502 |
Chain | Residue |
C | PHE110 |
C | LEU111 |
C | ALA114 |
C | HIS124 |
D | LEU28 |
D | ALA31 |
D | PHE32 |
D | HIS35 |
D | ILE68 |
D | PHE71 |
site_id | AC7 |
Number of Residues | 17 |
Details | binding site for residue TUM D 501 |
Chain | Residue |
D | PHE249 |
D | ASP252 |
D | LEU293 |
D | ARG303 |
D | ILE304 |
D | GLN44 |
D | ASP45 |
D | LEU46 |
D | ASN119 |
D | TRP122 |
D | LYS125 |
D | LEU126 |
D | PHE179 |
D | ASN185 |
D | ALA188 |
D | GLY189 |
D | ASN191 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue PGW D 502 |
Chain | Residue |
C | ALA31 |
C | HIS35 |
C | ILE68 |
D | CYS107 |
D | LEU111 |
D | ALA114 |
D | HIS124 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 220 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | MET1-PRO10 | |
B | GLU214-ARG218 | |
B | HIS270-PHE271 | |
B | LEU401-VAL408 | |
C | MET1-PRO10 | |
C | LEU79-PRO91 | |
C | PHE144-GLY166 | |
C | GLU214-ARG218 | |
C | HIS270-PHE271 | |
C | LEU401-VAL408 | |
D | MET1-PRO10 | |
A | LEU79-PRO91 | |
D | LEU79-PRO91 | |
D | PHE144-GLY166 | |
D | GLU214-ARG218 | |
D | HIS270-PHE271 | |
D | LEU401-VAL408 | |
A | PHE144-GLY166 | |
A | GLU214-ARG218 | |
A | HIS270-PHE271 | |
A | LEU401-VAL408 | |
B | MET1-PRO10 | |
B | LEU79-PRO91 | |
B | PHE144-GLY166 |
site_id | SWS_FT_FI2 |
Number of Residues | 108 |
Details | TRANSMEM: Helical; Name=Helix 1 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | LEU11-ALA38 | |
B | LEU11-ALA38 | |
C | LEU11-ALA38 | |
D | LEU11-ALA38 |
site_id | SWS_FT_FI3 |
Number of Residues | 456 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | ALA39-GLN58 | |
B | LEU294-HIS375 | |
C | ALA39-GLN58 | |
C | ASN119-ARG121 | |
C | LEU187-GLY192 | |
C | TRP243-VAL250 | |
C | LEU294-HIS375 | |
D | ALA39-GLN58 | |
D | ASN119-ARG121 | |
D | LEU187-GLY192 | |
D | TRP243-VAL250 | |
A | ASN119-ARG121 | |
D | LEU294-HIS375 | |
A | LEU187-GLY192 | |
A | TRP243-VAL250 | |
A | LEU294-HIS375 | |
B | ALA39-GLN58 | |
B | ASN119-ARG121 | |
B | LEU187-GLY192 | |
B | TRP243-VAL250 |
site_id | SWS_FT_FI4 |
Number of Residues | 76 |
Details | TRANSMEM: Helical; Name=Helix 2 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | GLY59-PHE78 | |
B | GLY59-PHE78 | |
C | GLY59-PHE78 | |
D | GLY59-PHE78 |
site_id | SWS_FT_FI5 |
Number of Residues | 104 |
Details | TRANSMEM: Helical; Name=Helix 3 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | HIS92-LEU118 | |
B | HIS92-LEU118 | |
C | HIS92-LEU118 | |
D | HIS92-LEU118 |
site_id | SWS_FT_FI6 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=Helix 4 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | TRP122-ASN143 | |
B | TRP122-ASN143 | |
C | TRP122-ASN143 | |
D | TRP122-ASN143 |
site_id | SWS_FT_FI7 |
Number of Residues | 76 |
Details | TRANSMEM: Helical; Name=Helix 5 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | ILE167-ILE186 | |
B | ILE167-ILE186 | |
C | ILE167-ILE186 | |
D | ILE167-ILE186 |
site_id | SWS_FT_FI8 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=Helix 6 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | LEU193-LEU213 | |
B | LEU193-LEU213 | |
C | LEU193-LEU213 | |
D | LEU193-LEU213 |
site_id | SWS_FT_FI9 |
Number of Residues | 92 |
Details | TRANSMEM: Helical; Name=Helix 7 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | ASP219-ASN242 | |
B | ASP219-ASN242 | |
C | ASP219-ASN242 | |
D | ASP219-ASN242 |
site_id | SWS_FT_FI10 |
Number of Residues | 72 |
Details | TRANSMEM: Helical; Name=Helix 8 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | GLY251-GLY269 | |
B | GLY251-GLY269 | |
C | GLY251-GLY269 | |
D | GLY251-GLY269 |
site_id | SWS_FT_FI11 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=Helix 9 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | SER272-LEU293 | |
B | SER272-LEU293 | |
C | SER272-LEU293 | |
D | SER272-LEU293 |
site_id | SWS_FT_FI12 |
Number of Residues | 96 |
Details | TRANSMEM: Helical; Name=Helix 10 => ECO:0000269|PubMed:29459785 |
Chain | Residue | Details |
A | GLU376-GLN400 | |
B | GLU376-GLN400 | |
C | GLU376-GLN400 | |
D | GLU376-GLN400 |
site_id | SWS_FT_FI13 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30388443 |
Chain | Residue | Details |
A | GLN44 | |
C | GLU56 | |
C | ASN191 | |
C | ARG301 | |
D | GLN44 | |
D | GLU56 | |
D | ASN191 | |
D | ARG301 | |
A | GLU56 | |
A | ASN191 | |
A | ARG301 | |
B | GLN44 | |
B | GLU56 | |
B | ASN191 | |
B | ARG301 | |
C | GLN44 |
site_id | SWS_FT_FI14 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5, ECO:0007744|PDB:6BW6 |
Chain | Residue | Details |
A | LEU46 | |
A | ARG303 | |
B | LEU46 | |
B | ARG303 | |
C | LEU46 | |
C | ARG303 | |
D | LEU46 | |
D | ARG303 |
site_id | SWS_FT_FI15 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5 |
Chain | Residue | Details |
A | ASN119 | |
A | ASP252 | |
B | ASN119 | |
B | ASP252 | |
C | ASN119 | |
C | ASP252 | |
D | ASN119 | |
D | ASP252 |
site_id | SWS_FT_FI16 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30388443 |
Chain | Residue | Details |
A | LYS125 | |
A | VAL178 | |
B | LYS125 | |
B | VAL178 | |
C | LYS125 | |
C | VAL178 | |
D | LYS125 | |
D | VAL178 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW6 |
Chain | Residue | Details |
A | ASN185 | |
B | ASN185 | |
C | ASN185 | |
D | ASN185 |
site_id | SWS_FT_FI18 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN146 | |
B | ASN146 | |
C | ASN146 | |
D | ASN146 |