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3ND4
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Watson-Crick 16-mer dsRNA
Descriptor: 5'-R(*AP*GP*AP*GP*AP*AP*GP*AP*UP*CP*UP*UP*CP*UP*CP*U)-3', MAGNESIUM ION, POTASSIUM ION, ...
Authors:Mooers, B.H, Singh, A.
Deposit date:2010-06-07
Release date:2011-09-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.524 Å)
Cite:The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate.
Rna, 17, 2011
6JP2
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Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus
Descriptor: Pyrrolysyl-tRNA synthetase
Authors:Yanagisawa, T, Kuratani, M, Yokoyama, S.
Deposit date:2019-03-25
Release date:2019-05-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.272 Å)
Cite:Fully Productive Cell-Free Genetic Code Expansion by Structure-Based Engineering ofMethanomethylophilus alvusPyrrolysyl-tRNA Synthetase.
Acs Synth Biol, 9, 2020
6HCW
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Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and a difluoro cyclohexyl chromone ligand
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LYSINE, Lysine--tRNA ligase, ...
Authors:Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
Deposit date:2018-08-16
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
7F98
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
Descriptor: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
Authors:Malhotra, N, Manickam, Y, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9D
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
Descriptor: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9C
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
Descriptor: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Malhotra, N, Manickam, Y, Sharma, A.
Deposit date:2021-07-04
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9A
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97
Descriptor: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9B
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BU of 7f9b by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
Descriptor: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F99
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BU of 7f99 by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
Descriptor: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
3VU8
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Metionyl-tRNA synthetase from Thermus thermophilus complexed with methionyl-adenylate analogue
Descriptor: Methionine--tRNA ligase, N-[METHIONYL]-N'-[ADENOSYL]-DIAMINOSULFONE, ZINC ION
Authors:Konno, M, Kato-Murayama, M, Toma-Fukai, S, Uchikawa, E, Nureki, O, Yokoyama, S.
Deposit date:2012-06-22
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The modeling of structures of specific conformation of homosysteine-AMP leading to thiolactone-formation on class Ia aminoacyl-tRNA synthetases
To be Published
4RQF
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human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ...
Authors:Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q.
Deposit date:2014-11-03
Release date:2015-11-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Nucleic Acids Res., 43, 2015
4RQE
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human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ...
Authors:Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q.
Deposit date:2014-11-03
Release date:2015-11-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4 Å)
Cite:SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Nucleic Acids Res., 43, 2015
4PY2
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BU of 4py2 by Molmil
Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA
Descriptor: 1,2-ETHANEDIOL, 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, Methionine--tRNA ligase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-03-25
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Plos One, 11, 2016
1EOV
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BU of 1eov by Molmil
FREE ASPARTYL-TRNA SYNTHETASE (ASPRS) (E.C. 6.1.1.12) FROM YEAST
Descriptor: ASPARTYL-TRNA SYNTHETASE
Authors:Sauter, C, Lorber, B, Cavarelli, J, Moras, D, Giege, R.
Deposit date:2000-03-24
Release date:2000-09-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domain.
J.Mol.Biol., 299, 2000
3TD6
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BU of 3td6 by Molmil
Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis from trigonal partially dehydrated crystal
Descriptor: Peptidyl-tRNA hydrolase
Authors:Selvaraj, M, Ahmad, R, Varshney, U, Vijayan, M.
Deposit date:2011-08-10
Release date:2012-02-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule
Acta Crystallogr.,Sect.F, 68, 2012
2FMT
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BU of 2fmt by Molmil
METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET
Descriptor: FORMYL-METHIONYL-TRNAFMET2, MAGNESIUM ION, METHIONYL-TRNA FMET FORMYLTRANSFERASE, ...
Authors:Schmitt, E, Mechulam, Y, Blanquet, S.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.
EMBO J., 17, 1998
1QTQ
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BU of 1qtq by Molmil
GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNA AND AN AMINO ACID ANALOG
Descriptor: 5'-O-[N-(L-GLUTAMINYL)-SULFAMOYL]ADENOSINE, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE), RNA (TRNA GLN II ), ...
Authors:Rath, V.L, Silvian, L.F, Beijer, B, Sproat, B.S, Steitz, T.A.
Deposit date:1998-01-28
Release date:1998-05-27
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:How glutaminyl-tRNA synthetase selects glutamine.
Structure, 6, 1998
2ZNI
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BU of 2zni by Molmil
Crystal structure of Pyrrolysyl-tRNA synthetase-tRNA(Pyl) complex from Desulfitobacterium hafniense
Descriptor: CALCIUM ION, Pyrrolysyl-tRNA synthetase, bacterial tRNA
Authors:Nozawa, K, Araiso, Y, Soll, D, Ishitani, R, Nureki, O.
Deposit date:2008-04-25
Release date:2008-12-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecular basis of orthogonality
Nature, 457, 2009
8X5U
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Crystal structure of Thermus thermophilus peptidyl-tRNA hydrolase C-terminal 16 amino acid deletion mutant
Descriptor: Peptidyl-tRNA hydrolase, SULFATE ION
Authors:Uehara, Y, Matsumoto, A, Nakazawa, T, Fukuta, A, Ando, K, Oka, N, Uchiumi, T, Ito, K.
Deposit date:2023-11-19
Release date:2024-11-20
Last modified:2025-06-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding mode between peptidyl-tRNA hydrolase and the peptidyl-A76 moiety of the substrate.
J.Biol.Chem., 301, 2025
8XM4
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BU of 8xm4 by Molmil
Methionyl-tRNA synthetase from Staphylococcus aureus in complex with chlorhexidine and ATP
Descriptor: 1,2-ETHANEDIOL, 1-[6-[azanylidene-[[azanylidene-[[(4-chlorophenyl)amino]methyl]-$l^{4}-azanyl]methyl]-$l^{4}-azanyl]hexyl]-3-[~{N}-(4-chlorophenyl)carbamimidoyl]guanidine, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lu, F, Xia, K, Yi, J, Chen, B, Luo, Z, Xu, J, Gu, Q, Zhou, H.
Deposit date:2023-12-27
Release date:2024-11-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria.
Eur.J.Med.Chem., 268, 2024
8XM3
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BU of 8xm3 by Molmil
Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a chlorhexidine derivative and ATP
Descriptor: 1-(4-chlorophenyl)-3-[~{N}-[4-[[~{N}-[~{N}-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]butyl]carbamimidoyl]guanidine, ADENOSINE-5'-TRIPHOSPHATE, Methionine--tRNA ligase
Authors:Lu, F, Xia, K, Yi, J, Chen, B, Luo, Z, Xu, J, Gu, Q, Zhou, H.
Deposit date:2023-12-27
Release date:2024-11-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria.
Eur.J.Med.Chem., 268, 2024
4KR3
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BU of 4kr3 by Molmil
Glycyl-tRNA synthetase mutant E71G in complex with tRNA-Gly
Descriptor: GLYCINE, Gly-tRNA-CCC, Glycine--tRNA ligase, ...
Authors:Qin, X, Hao, Z, Tian, Q, Zhang, Z, Zhou, C, Xie, W.
Deposit date:2013-05-16
Release date:2014-05-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.235 Å)
Cite:Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation
J.Biol.Chem., 289, 2014
4KR2
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Glycyl-tRNA synthetase in complex with tRNA-Gly
Descriptor: ADENOSINE MONOPHOSPHATE, Gly-tRNA-CCC, Glycine--tRNA ligase
Authors:Qin, X, Hao, Z, Tian, Q, Zhang, Z, Zhou, C, Xie, W.
Deposit date:2013-05-16
Release date:2014-05-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.292 Å)
Cite:Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation
J.Biol.Chem., 289, 2014
1E1T
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BU of 1e1t by Molmil
LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM COMPLEXED WITH THE LYSYL_ADENYLATE INTERMEDIATE
Descriptor: ADENOSINE-5'-[LYSYL-PHOSPHATE], GLYCEROL, LYSYL-TRNA SYNTHETASE, ...
Authors:Desogus, G, Todone, F, Brick, P, Onesti, S.
Deposit date:2000-05-10
Release date:2000-07-28
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction
Biochemistry, 39, 2000
1E1O
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lysyl-tRNA Synthetase (LYSU) hexagonal form, complexed with lysine
Descriptor: GLYCEROL, LYSINE, LYSYL-TRNA SYNTHETASE, ...
Authors:Desogus, G, Todone, F, Brick, P, Onesti, S.
Deposit date:2000-05-09
Release date:2000-07-28
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction
Biochemistry, 39, 2000

238582

数据于2025-07-09公开中

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