6PDZ
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2UX7
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![BU of 2ux7 by Molmil](/molmil-images/mine/2ux7) | Pseudoazurin with engineered amicyanin ligand loop, reduced form, pH 7.5 | Descriptor: | CHLORIDE ION, COPPER (II) ION, GLYCEROL, ... | Authors: | Velarde, M, Huber, R, Yanagisawa, S, Dennison, C, Messerschmidt, A. | Deposit date: | 2007-03-27 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin. Biochemistry, 46, 2007
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2UX6
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![BU of 2ux6 by Molmil](/molmil-images/mine/2ux6) | Pseudoazurin with engineered amicyanin ligand loop, oxidized form, pH 7.5 | Descriptor: | CHLORIDE ION, COPPER (II) ION, GLYCEROL, ... | Authors: | Velarde, M, Huber, R, Yanagisawa, S, Dennison, C, Messerschmidt, A. | Deposit date: | 2007-03-27 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Influence of Loop Shortening on the Metal Binding Site of Cupredoxin Pseudoazurin. Biochemistry, 46, 2007
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3I6Z
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![BU of 3i6z by Molmil](/molmil-images/mine/3i6z) | 3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{6-[(4aS,6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]hexyl}-1 ,2-benzisothiazol-3(2H)-one 1,1-dioxide, ... | Authors: | Lamba, D, Bartolucci, C. | Deposit date: | 2009-07-07 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53, 2010
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3UU3
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![BU of 3uu3 by Molmil](/molmil-images/mine/3uu3) | The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a locally-closed conformation (LC1 subtype) | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-11-28 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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3UU6
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![BU of 3uu6 by Molmil](/molmil-images/mine/3uu6) | The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' mutant reduced in solution | Descriptor: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-11-28 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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7XFW
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![BU of 7xfw by Molmil](/molmil-images/mine/7xfw) | Crystal structure of the ternary complex of Peptidoglycan recognition protein, PGRP-S with hexanoic and tartaric acids at 2.07 A resolution. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Maurya, A, Singh, P.K, Viswanathan, V, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2022-04-02 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure of the complex of camel peptidoglycan recognition protein-S with hexanoic acid reveals novel features of the versatile ligand-binding site at the dimeric interface. Biochim Biophys Acta Proteins Proteom, 1871, 2022
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8IQU
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![BU of 8iqu by Molmil](/molmil-images/mine/8iqu) | Structure of MtbFadD23 with PhU-AMS | Descriptor: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, Fatty-acid-CoA ligase FadD23 | Authors: | Yan, M.R, Zhang, W. | Deposit date: | 2023-03-17 | Release date: | 2023-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.F, 79, 2023
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3UUB
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![BU of 3uub by Molmil](/molmil-images/mine/3uub) | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution | Descriptor: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-11-28 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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7ZS8
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![BU of 7zs8 by Molmil](/molmil-images/mine/7zs8) | Mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae at 1.4 Angstrom resolution | Descriptor: | CALCIUM ION, Cytochrome-c peroxidase, HEME C, ... | Authors: | Carvalho, A.L, Romao, M.J, Pauleta, S, Nobrega, C. | Deposit date: | 2022-05-06 | Release date: | 2023-04-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Characterization of Neisseria gonorrhoeae Bacterial Peroxidase-Insights into the Catalytic Cycle of Bacterial Peroxidases. Int J Mol Sci, 24, 2023
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7LD0
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![BU of 7ld0 by Molmil](/molmil-images/mine/7ld0) | Cryo-EM structure of ligand-free Human SARM1 | Descriptor: | NAD(+) hydrolase SARM1 | Authors: | Nanson, J.D, Gu, W, Luo, Z, Jia, X, Landsberg, M.J, Kobe, B, Ve, T. | Deposit date: | 2021-01-12 | Release date: | 2021-03-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109, 2021
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7LCY
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![BU of 7lcy by Molmil](/molmil-images/mine/7lcy) | Crystal structure of the ligand-free ARM domain from Drosophila SARM1 | Descriptor: | Isoform B of NAD(+) hydrolase sarm1 | Authors: | Gu, W, Nanson, J.D, Luo, Z, McGuinness, H.Y, Manik, M.K, Jia, X, Ve, T, Kobe, B. | Deposit date: | 2021-01-12 | Release date: | 2021-03-10 | Last modified: | 2021-04-21 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109, 2021
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4GIQ
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![BU of 4giq by Molmil](/molmil-images/mine/4giq) | Crystal Structure of mouse RANK bound to RANKL | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... | Authors: | Nelson, C.A, Wang, M.W.-H, Fremont, D.H. | Deposit date: | 2012-08-08 | Release date: | 2012-10-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
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7AU5
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![BU of 7au5 by Molmil](/molmil-images/mine/7au5) | Tubulin-noscapine-analogue-14e complex | Descriptor: | (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Yong, C, Devine, S.M, Abel, A.-C, Muthiah, D, Gao, X, Callaghan, R, Capuano, B, Steinmetz, M.O, Prota, A.E, Scammels, P.J. | Deposit date: | 2020-11-02 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. Chemmedchem, 16, 2021
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3GBW
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![BU of 3gbw by Molmil](/molmil-images/mine/3gbw) | Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2) | Descriptor: | E3 ubiquitin-protein ligase MYCBP2 | Authors: | Sampathkumar, P, Ozyurt, S.A, Wasserman, S.R, Klemke, R.L, Miller, S.A, Bain, K.T, Rutter, M.E, Tarun, G, Atwell, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-02-20 | Release date: | 2009-03-24 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1. J.Mol.Biol., 397, 2010
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5NH3
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![BU of 5nh3 by Molmil](/molmil-images/mine/5nh3) | CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, ... | Authors: | Scheufler, C. | Deposit date: | 2017-03-21 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6QCI
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![BU of 6qci by Molmil](/molmil-images/mine/6qci) | Structure of XIAP-BIR1 V86E mutant | Descriptor: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase XIAP, SODIUM ION, ... | Authors: | Sorrentino, L, Cossu, F, Milani, M, Mastrangelo, E. | Deposit date: | 2018-12-28 | Release date: | 2019-05-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1. Chemistryopen, 8, 2019
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8QD2
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![BU of 8qd2 by Molmil](/molmil-images/mine/8qd2) | Ayg1p in complex with 1,3-Dihydroxynaphthalene | Descriptor: | Pigment biosynthesis protein yellowish-green 1, naphthalene-1,3-diol | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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8QD3
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![BU of 8qd3 by Molmil](/molmil-images/mine/8qd3) | Ayg1p in complex with 1,3,6,8-Tetrahydroxynaphthalene | Descriptor: | 1,2-ETHANEDIOL, FLAVIOLIN, Pigment biosynthesis protein yellowish-green 1, ... | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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8QD4
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![BU of 8qd4 by Molmil](/molmil-images/mine/8qd4) | Ayg1p active site converted to tetrahedral sulfonate ester | Descriptor: | Pigment biosynthesis protein yellowish-green 1, phenylmethanesulfonic acid | Authors: | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | Deposit date: | 2023-08-28 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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7XP5
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![BU of 7xp5 by Molmil](/molmil-images/mine/7xp5) | Cryo-EM structure of a class T GPCR in ligand-free state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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2N8T
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6X4G
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![BU of 6x4g by Molmil](/molmil-images/mine/6x4g) | Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ICOS ligand, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-05-22 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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2UUQ
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3UU4
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![BU of 3uu4 by Molmil](/molmil-images/mine/3uu4) | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in the crystal in a locally-closed conformation (LC1 subtype) | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-11-28 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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