PDB: 12060 resultsInfo pagesStatus searchChemie searchBIRD

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7DHK	The co-crystal structure of DYRK2 with a small molecule inhibitor 13 Descriptor: 2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Wei, T, Xiao, J. Deposit date: 2020-11-16 Release date: 2021-11-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.341 Å) Cite: Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DHV	The co-crystal structure of DYRK2 with a small molecule inhibitor 8 Descriptor: 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine-4-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Wei, T, Xiao, J. Deposit date: 2020-11-17 Release date: 2021-11-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.679 Å) Cite: Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DJO	The co-crystal structure of DYRK2 with a small molecule inhibitor 17 Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol Authors: Wei, T, Xiao, J. Deposit date: 2020-11-20 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DL6	The co-crystal structure of DYRK2 with a small molecule inhibitor 18 Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol Authors: Wei, T, Xiao, J. Deposit date: 2020-11-26 Release date: 2021-12-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.648 Å) Cite: Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
4IGK	Structure of human BRCA1 BRCT in complex with ATRIP peptide Descriptor: ATRIP peptide, Breast cancer type 1 susceptibility protein, GLYCEROL Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-17 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
2JAU	Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, 5'(3')-DEOXYRIBONUCLEOTIDASE, MAGNESIUM ION, ... Authors: Wallden, K, Ruzzenente, B, Bianchi, V, Nordlund, P. Deposit date: 2006-11-30 Release date: 2007-12-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues. Biochemistry, 46, 2007
5ZTN	The crystal structure of human DYRK2 in complex with Curcumin Descriptor: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Ji, C.G, Xiao, J.Y. Deposit date: 2018-05-04 Release date: 2018-07-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.496 Å) Cite: Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ZWK	Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) Descriptor: CHLORIDE ION, Histone H2AX, SODIUM ION, ... Authors: McEwen, A.G, Moeglin, E, Desplancq, D, Weiss, E, Poterszman, A. Deposit date: 2020-07-28 Release date: 2021-07-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress. Cancers (Basel), 13, 2021
5MNJ	Structure of MDM2-MDMX-UbcH5B-ubiquitin complex Descriptor: E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ... Authors: Klejnot, M, Huang, D.T. Deposit date: 2016-12-13 Release date: 2017-05-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat. Struct. Mol. Biol., 24, 2017
8Q1Y	Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-01 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q25	Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-01 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q1U	Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-01 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q1P	Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-01 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
4UXA	Improved variant of (R)-selective manganese-dependent hydroxynitrile lyase from bacteria Descriptor: CUPIN 2 CONSERVED BARREL DOMAIN PROTEIN, MANGANESE (II) ION Authors: Pavkov-Keller, T, Wiedner, R, Kothbauer, B, Gruber-Khadjawi, M, Schwab, H, Steiner, K, Gruber, K. Deposit date: 2014-08-21 Release date: 2015-01-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Improving the Properties of Bacterial R-Selective Hydroxynitrile Lyases for Industrial Applications Chemcatchem, 2015
3DQ1	Structure of the Yellow Fluorescent Protein Citrine Frozen at 4000 Atmospheres Number 2: Structure 24 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQA	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1250 Atmospheres Number 4: Structure 14 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQ6	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1920 Atmospheres Number 2: Structure 18 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQL	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1000 Atmospheres Number 1: Structure 5 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQ3	Structure of the Yellow Fluorescent Protein Citrine Frozen at 2500 Atmospheres: Structure 22 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQD	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1250 Atmospheres Number 2: Structure 12 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQN	Structure of the Yellow Fluorescent Protein Citrine Frozen at 500 Atmospheres: Structure 3 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
5N84	TTK kinase domain in complex with Mps-BAY2b Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, Dual specificity protein kinase TTK, SODIUM ION, ... Authors: Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R. Deposit date: 2017-02-22 Release date: 2017-05-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
3DQH	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1000 Atmospheres Number 5: Structure 9 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQ9	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1500 Atmospheres Number 1: Structure 15 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DQM	Structure of the Yellow Fluorescent Protein Citrine Frozen at 750 Atmospheres: Structure 4 in a Series of 26 High Pressure Structures Descriptor: Green fluorescent protein Authors: Barstow, B, Kim, C.U. Deposit date: 2008-07-09 Release date: 2008-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008

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