5ZTN
The crystal structure of human DYRK2 in complex with Curcumin
Summary for 5ZTN
| Entry DOI | 10.2210/pdb5ztn/pdb |
| Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 2, (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (3 entities in total) |
| Functional Keywords | inhibitor of kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 99778.61 |
| Authors | Ji, C.G.,Xiao, J.Y. (deposition date: 2018-05-04, release date: 2018-07-18, Last modification date: 2023-11-22) |
| Primary citation | Banerjee, S.,Ji, C.,Mayfield, J.E.,Goel, A.,Xiao, J.,Dixon, J.E.,Guo, X. Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc. Natl. Acad. Sci. U.S.A., 115:8155-8160, 2018 Cited by PubMed: 29987021DOI: 10.1073/pnas.1806797115 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.496 Å) |
Structure validation
Download full validation report
