5ZTN

The crystal structure of human DYRK2 in complex with Curcumin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dual specificity tyrosine-phosphorylation-regulated kinase 2	polymer	429	49520.9	2	UniProt (Q92630) Pfam (PF00069)	Homo sapiens (Human)
2	C, D (A, B)	(1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one	non-polymer		368.4	2	Chemie (CUR)
3	E, F (A, B)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A, B: 73 - 479 (UniProt: Q92630)

PDB	External Database	Details
Met 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
Ser 58	-	expression tag
Ser 59	-	expression tag
Gly 60	-	expression tag
Val 61	-	expression tag
Asp 62	-	expression tag
Leu 63	-	expression tag
Gly 64	-	expression tag
Thr 65	-	expression tag
Glu 66	-	expression tag
Asn 67	-	expression tag
Leu 68	-	expression tag
Tyr 69	-	expression tag
Phe 70	-	expression tag
Gln 71	-	expression tag
Ser 72	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	99041.9
Non-Polymers*	Number of molecules	2
	Total formula weight	736.8
All*	Total formula weight	99778.6

*Water molecules are not included.