5V7Q
| Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Yang, K, Chang, J.-Y, Cui, Z, Zhang, J. | Deposit date: | 2017-03-20 | Release date: | 2017-09-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res., 45, 2017
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8ONZ
| Chaetomium thermophilum Methionine Aminopeptidase 2 at the 80S ribosome | Descriptor: | 28S rRNA, 5.8S rRNA, 60S ribosomal protein L25-like protein, ... | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | Deposit date: | 2023-04-04 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome. Nat Commun, 15, 2024
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5TMF
| Re-refinement of thermus thermophilus RNA polymerase | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Wang, J. | Deposit date: | 2016-10-12 | Release date: | 2016-11-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | On the validation of crystallographic symmetry and the quality of structures. Protein Sci., 24, 2015
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5SZW
| NMR solution structure of the RRM1 domain of the post-transcriptional regulator HuR | Descriptor: | ELAV-like protein 1 | Authors: | Lixa, C, Mujo, A, Jendiroba, K.A, Almeida, F.C.L, Lima, L.M.T.R, Pinheiro, A.S. | Deposit date: | 2016-08-15 | Release date: | 2017-09-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution. J. Biomol. NMR, 72, 2018
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5L1Z
| TAR complex with HIV-1 Tat-AFF4-P-TEFb | Descriptor: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | Authors: | Schulze-Gahmen, U, Hurley, J. | Deposit date: | 2016-07-29 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (5.9 Å) | Cite: | Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife, 5, 2016
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2P1D
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6XEZ
| Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-06-14 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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2XZP
| Upf1 helicase | Descriptor: | GLYCEROL, MALONATE ION, REGULATOR OF NONSENSE TRANSCRIPTS 1 | Authors: | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | Deposit date: | 2010-11-26 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2. Mol.Cell, 41, 2011
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5E57
| Crystal structure of Mycobacterium smegmatis AmtR | Descriptor: | ACETATE ION, Transcription regulator AmtR | Authors: | Vickers, C.J, McKenzie, J.L, Arcus, V.L. | Deposit date: | 2015-10-07 | Release date: | 2016-09-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structure and Function of AmtR in Mycobacterium smegmatis: Implications for Post-Transcriptional Regulation of Urea Metabolism through a Small Antisense RNA. J.Mol.Biol., 428, 2016
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1W18
| Crystal Structure of levansucrase from Gluconacetobacter diazotrophicus | Descriptor: | LEVANSUCRASE, SULFATE ION | Authors: | Martinez-Fleites, C, Ortiz-Lombardia, M, Pons, T, Tarbouriech, N, Taylor, E.J, Hernandez, L, Davies, G.J. | Deposit date: | 2004-06-16 | Release date: | 2005-05-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Levansucrase from the Gram- Negative Bacterium Gluconacetobacter Diazotrophicus. Biochem.J., 390, 2005
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1EAI
| COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE | Descriptor: | PROTEIN (CHYMOTRYPSIN/ELASTASE ISOINHIBITOR 1), PROTEIN (ELASTASE) | Authors: | Huang, K, Strynadka, N.C.J, Bernard, V.D, Peanasky, R.J, James, M.N.G. | Deposit date: | 1999-03-25 | Release date: | 1999-04-05 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure, 2, 1994
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6LDT
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7PO6
| Xist (m6A)UCG tetraloop RNA bound to the YTH domain of YTHDC1 | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, Isoform 2 of YTH domain-containing protein 1, ... | Authors: | Jones, A.N, Mourao, A, Sattler, M. | Deposit date: | 2021-09-08 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1. Nucleic Acids Res., 50, 2022
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3IBV
| Karyopherin cytosolic state | Descriptor: | CALCIUM ION, Exportin-T | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-17 | Release date: | 2009-08-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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1W77
| 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Arabidopsis thaliana | Descriptor: | 2C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CADMIUM ION, COPPER (II) ION, ... | Authors: | Gabrielsen, M, Kaiser, J, Rohdich, F, Eisenreich, W, Bacher, A, Bond, C.S, Hunter, W.N. | Deposit date: | 2004-08-30 | Release date: | 2006-02-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of a Plant 2C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase Exhibits a Distinct Quaternary Structure Compared to Bacterial Homologues and a Possible Role in Feedback Regulation for Cytidine Monophosphate. FEBS J., 273, 2006
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5C45
| Selective Small Molecule Inhibition of the FMN Riboswitch | Descriptor: | (6M)-2-[(3S)-1-{[2-(methylamino)pyrimidin-5-yl]methyl}piperidin-3-yl]-6-(thiophen-2-yl)pyrimidin-4-ol, FMN Riboswitch, MAGNESIUM ION, ... | Authors: | Fischmann, T.O. | Deposit date: | 2015-06-17 | Release date: | 2015-10-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Selective small-molecule inhibition of an RNA structural element. Nature, 526, 2015
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7BJG
| Crystal structure of atypical Tm1 (Tm1-I/C), residues 262-363 | Descriptor: | SD21996p | Authors: | Dimitrova-Paternoga, L, Jagtap, P.K.A, Ephrussi, A, Hennig, J. | Deposit date: | 2021-01-14 | Release date: | 2021-05-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex. Genes Dev., 35, 2021
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3TMA
| Crystal structure of TrmN from Thermus thermophilus | Descriptor: | PHOSPHATE ION, methyltransferase | Authors: | Fislage, M, Roovers, M, Tuszynska, I, Bujnicki, J.M, Droogmans, L, Versees, W. | Deposit date: | 2011-08-31 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res., 40, 2012
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5MKQ
| TtuA enzyme containing a [4Fe-4S] | Descriptor: | IRON/SULFUR CLUSTER, TtuA PH0300, ZINC ION | Authors: | Arragain, S, Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | Deposit date: | 2016-12-05 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8QVU
| Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex | Descriptor: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A. | Deposit date: | 2023-10-18 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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6C90
| Human Mtr4 helicase in complex with ZCCHC8-CTD | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Exosome RNA helicase MTR4,Exosome RNA helicase MTR4, L(+)-TARTARIC ACID, ... | Authors: | Puno, M.R, Lima, C.D. | Deposit date: | 2018-01-25 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3STB
| A complex of two editosome proteins and two nanobodies | Descriptor: | MP18 RNA editing complex protein, RNA-editing complex protein MP42, single domain antibody VHH | Authors: | Park, Y.-J, Hol, W. | Deposit date: | 2011-07-09 | Release date: | 2011-11-02 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res., 40, 2012
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1DET
| RIBONUCLEASE T1 CARBOXYMETHYLATED AT GLU 58 IN COMPLEX WITH 2'GMP | Descriptor: | GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1, SODIUM ION | Authors: | Ishikawa, K, Suzuki, E, Tanokura, M, Takahashi, K. | Deposit date: | 1996-02-20 | Release date: | 1996-07-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of ribonuclease T1 carboxymethylated at Glu58 in complex with 2'-GMP. Biochemistry, 35, 1996
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1DJ0
| THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION | Descriptor: | CHLORIDE ION, PSEUDOURIDINE SYNTHASE I | Authors: | Foster, P.G, Huang, L, Santi, D.V, Stroud, R.M. | Deposit date: | 1999-11-30 | Release date: | 2000-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat.Struct.Biol., 7, 2000
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1RA7
| Poliovirus Polymerase with GTP | Descriptor: | ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein | Authors: | Thompson, A.A, Peersen, O.B. | Deposit date: | 2003-10-31 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
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