1H88
| CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX1 | Descriptor: | AMMONIUM ION, CCAAT/ENHANCER BINDING PROTEIN BETA, DNA(5'-(*CP*CP*AP*GP*TP*CP*CP*GP*TP*TP*AP* AP*GP*GP*AP*TP*TP*GP*CP*GP*CP*CP*AP*CP*AP*T)-3'), ... | Authors: | Tahirov, T.H, Ogata, K. | Deposit date: | 2001-01-29 | Release date: | 2002-01-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanism of C-Myb-C/Ebpbeta Cooperation from Separated Sites on a Promoter Cell(Cambridge,Mass.), 108, 2002
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6GTF
| Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*A)-3'), ... | Authors: | Montoya, G, Mesa, P, Stella, S. | Deposit date: | 2018-06-18 | Release date: | 2018-12-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018
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7C5C
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6GTD
| Transient state structure of CRISPR-Cpf1 (Cas12a) I2 conformation | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), ... | Authors: | Montoya, G, Mesa, P. | Deposit date: | 2018-06-18 | Release date: | 2018-12-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.24 Å) | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018
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3U9G
| Crystal structure of the Zinc finger antiviral protein | Descriptor: | ZINC ION, Zinc finger CCCH-type antiviral protein 1 | Authors: | Chen, S, Xu, Y, Zhang, K, Wang, X, Sun, J, Gao, G, Liu, Y. | Deposit date: | 2011-10-18 | Release date: | 2012-03-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Nat.Struct.Mol.Biol., 19, 2012
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3D1K
| R/T intermediate quaternary structure of an antarctic fish hemoglobin in an alpha(CO)-beta(pentacoordinate) state | Descriptor: | ACETYL GROUP, CARBON MONOXIDE, Hemoglobin subunit alpha-1, ... | Authors: | Vitagliano, L, Vergara, A, Bonomi, G, Merlino, A, Mazzarella, L. | Deposit date: | 2008-05-06 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state. J.Am.Chem.Soc., 130, 2008
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3QLH
| HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket | Descriptor: | (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | Authors: | Himmel, D.M, Wojtak, K, Bauman, J.D, Arnold, E. | Deposit date: | 2011-02-02 | Release date: | 2011-12-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem., 54, 2011
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6RA1
| Human Cyclophilin D in complex with norbornane fragment derivative | Descriptor: | 14-ethyl-4,6-dioxa-10,14-diazatricyclo[7.6.0.0^{3,7}]pentadeca-1(9),2,7-trien-13-one, 2-[(1~{R},2~{R},6~{S},7~{S})-3,5-bis(oxidanylidene)-4-azatricyclo[5.2.1.0^{2,6}]decan-4-yl]ethanoic acid, DI(HYDROXYETHYL)ETHER, ... | Authors: | Graedler, U. | Deposit date: | 2019-04-05 | Release date: | 2019-11-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies. Bioorg.Med.Chem.Lett., 29, 2019
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3DEN
| Structure of E. coli DHDPS mutant Y107W | Descriptor: | Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Pearce, F.G, Gerrard, J.A, Perugini, M.A, Jameson, G.B. | Deposit date: | 2008-06-10 | Release date: | 2008-11-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme Biochemistry, 47, 2008
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3MP4
| Crystal structure of Human lyase R41M mutant | Descriptor: | Hydroxymethylglutaryl-CoA lyase | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
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4PH6
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3MP3
| Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | Descriptor: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
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5JJK
| Rho transcription termination factor bound to rA7 and 6 ADP-BeF3 molecules | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M. | Deposit date: | 2016-04-24 | Release date: | 2016-11-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7ZJ1
| Crystal structure of ADAR1-dsRBD3 dimer | Descriptor: | Double-stranded RNA-specific adenosine deaminase | Authors: | Mboukou, A, Barraud, P. | Deposit date: | 2022-04-08 | Release date: | 2023-10-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Dimerization of ADAR1 modulates site-specificity of RNA editing Biorxiv, 2023
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8R63
| Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition | Descriptor: | 5-(1~{H}-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') | Authors: | Malard, F, Campagne, S. | Deposit date: | 2023-11-20 | Release date: | 2024-03-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52, 2024
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8CX2
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX0
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX1
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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7PKQ
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7OM9
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1XBI
| High resolution structure of Methanocaldococcus jannaschii L7AE | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 50S ribosomal protein L7Ae | Authors: | Brown II, B.A, Suryadi, J, Lieberman, D.V, Tran, E.J, Maxwell, E.S. | Deposit date: | 2004-08-30 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Crystal Structure of the Methanocaldococcus jannaschii Multifunctional L7Ae RNA-Binding Protein Reveals an Induced-Fit Interaction with the Box C/D RNAs. Biochemistry, 44, 2005
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4WFL
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5WWN
| Crystal structure of Tsr1 | Descriptor: | Ribosome biogenesis protein TSR1, SULFATE ION | Authors: | Ye, K, Wang, B. | Deposit date: | 2017-01-03 | Release date: | 2017-06-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Molecular architecture of the 90S small subunit pre-ribosome Elife, 6, 2017
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4RKV
| Structural variations and solvent structure of UGGGGU quadruplexes stabilized by Sr2+ ions | Descriptor: | CALCIUM ION, RNA (5'-R(*UP*GP*GP*GP*GP*U)-3'), SODIUM ION, ... | Authors: | Fyfe, A.C, Dunten, P.W, Scott, W.G. | Deposit date: | 2014-10-14 | Release date: | 2014-11-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (0.88 Å) | Cite: | Structural Variations and Solvent Structure of r(UGGGGU) Quadruplexes Stabilized by Sr(2+) Ions. J.Mol.Biol., 427, 2015
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5JJL
| Rho transcription termination factor bound to rU8 and 5 ADP-BeF3 molecules | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M. | Deposit date: | 2016-04-24 | Release date: | 2016-11-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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