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6GTF

Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation

Summary for 6GTF
Entry DOI10.2210/pdb6gtf/pdb
EMDB information0064
DescriptorCRISPR-associated endonuclease Cas12a, RNA (29-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), ... (4 entities in total)
Functional Keywordscrispr genome editing ribonucleoprotein complex, hydrolase
Biological sourceFrancisella tularensis subsp. novicida U112
More
Total number of polymer chains4
Total formula weight203280.74
Authors
Montoya, G.,Mesa, P.,Stella, S. (deposition date: 2018-06-18, release date: 2018-12-19, Last modification date: 2019-12-11)
Primary citationStella, S.,Mesa, P.,Thomsen, J.,Paul, B.,Alcon, P.,Jensen, S.B.,Saligram, B.,Moses, M.E.,Hatzakis, N.S.,Montoya, G.
Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175:1856-1871.e21, 2018
Cited by
PubMed: 30503205
DOI: 10.1016/j.cell.2018.10.045
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.63 Å)
Structure validation

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