6RA1

Human Cyclophilin D in complex with norbornane fragment derivative

Summary for 6RA1

Entry DOI	10.2210/pdb6ra1/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, 2-[(1~{R},2~{R},6~{S},7~{S})-3,5-bis(oxidanylidene)-4-azatricyclo[5.2.1.0^{2,6}]decan-4-yl]ethanoic acid, 14-ethyl-4,6-dioxa-10,14-diazatricyclo[7.6.0.0^{3,7}]pentadeca-1(9),2,7-trien-13-one, ... (7 entities in total)
Functional Keywords	cyclophilin, beta barrel, prolyl cis/trans isomerase, mitoc, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18616.10
Authors	Graedler, U. (deposition date: 2019-04-05, release date: 2019-11-27, Last modification date: 2024-01-24)
Primary citation	Gradler, U.,Schwarz, D.,Blaesse, M.,Leuthner, B.,Johnson, T.L.,Bernard, F.,Jiang, X.,Marx, A.,Gilardone, M.,Lemoine, H.,Roche, D.,Jorand-Lebrun, C. Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies. Bioorg.Med.Chem.Lett., 29:126717-126717, 2019 Cited by PubMed: 31635932 DOI: 10.1016/j.bmcl.2019.126717 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation