8E0S
| DAHP (3-deoxy-D-arabinoheptulosonate-7-phosphate) Synthase complexed with DAHP Oxime in unbound:(bound)2:unbound conformations | Descriptor: | DAHP Oxime, Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, ... | Authors: | Berti, P.J, Junop, M.S, Grainger, R. | Deposit date: | 2022-08-09 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation. Biochemistry, 61, 2022
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6DQY
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5YO9
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5YOA
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8GN8
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6DUY
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1OJG
| Sensory domain of the membraneous two-component fumarate sensor DcuS of E. coli | Descriptor: | SENSOR PROTEIN DCUS | Authors: | Pappalardo, L, Janausch, I.G, Vijayan, V, Zientz, E, Junker, J, Peti, W, Zweckstetter, M, Unden, G, Griesinger, C. | Deposit date: | 2003-07-10 | Release date: | 2003-08-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J. Biol. Chem., 278, 2003
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2AQB
| Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli | Descriptor: | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | Authors: | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | Deposit date: | 2005-08-17 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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5KUE
| Human SeMet incorporated I141M/L146M mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Calcium uniporter protein, ... | Authors: | Mok, C.Y.M, Lee, S.K, Junop, M.S, Stathopulos, P.B. | Deposit date: | 2016-07-13 | Release date: | 2016-09-07 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016
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5YZU
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1RQ5
| Structural Basis for the Exocellulase Activity of the Cellobiohydrolase CbhA from C. thermocellum | Descriptor: | CALCIUM ION, Cellobiohydrolase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Schubot, F.D, Kataeva, I.A, Chang, J, Shah, A.K, Ljungdahl, L.G, Rose, J.P, Wang, B.C. | Deposit date: | 2003-12-04 | Release date: | 2004-03-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the exocellulase activity of the cellobiohydrolase CbhA from Clostridium thermocellum Biochemistry, 43, 2004
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5KUG
| Human mitochondrial calcium uniporter (residues 72-189) crystal structure with lithium | Descriptor: | Calcium uniporter protein, mitochondrial | Authors: | Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B. | Deposit date: | 2016-07-13 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016
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5KUJ
| Human mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium. | Descriptor: | Calcium uniporter protein, mitochondrial, MAGNESIUM ION | Authors: | Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B. | Deposit date: | 2016-07-13 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016
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3PDO
| Crystal Structure of HLA-DR1 with CLIP102-120 | Descriptor: | FORMIC ACID, GLYCEROL, HLA class II histocompatibility antigen gamma chain, ... | Authors: | Gunther, S, Schlundt, A, Sticht, J, Roske, Y, Heinemann, U, Wiesmuller, K.-H, Jung, G, Falk, K, Rotzschke, O, Freund, C. | Deposit date: | 2010-10-23 | Release date: | 2010-12-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc.Natl.Acad.Sci.USA, 107, 2010
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6CKD
| Structure of a new ShKT peptide from the sea anemone Oulactis sp: OspTx2a-p1 | Descriptor: | OspTx2a-p1 | Authors: | Sunanda, P, Krishnarjuna, B, Norton, R.S. | Deposit date: | 2018-02-27 | Release date: | 2019-02-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp. Peptide Science, 110, 2018
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1YW2
| Mutated Mus Musculus P38 Kinase (mP38) | Descriptor: | 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14 | Authors: | Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J. | Deposit date: | 2005-02-16 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15, 2005
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1ZKJ
| Structural Basis for the Extended Substrate Spectrum of CMY-10, a Plasmid-Encoded Class C beta-lactamase | Descriptor: | ACETIC ACID, ZINC ION, extended-spectrum beta-lactamase | Authors: | Cha, S.S, Jung, H.I, An, Y.J, Lee, S.H. | Deposit date: | 2005-05-03 | Release date: | 2006-04-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase. Mol.Microbiol., 60, 2006
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1OXD
| Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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5KKM
| Con-Vc11-22 | Descriptor: | O2_contryphan_Vc1 prepropeptide | Authors: | Chittoor, B, Krishnarjuna, B, MacRaild, C.A, Robinson, S.D. | Deposit date: | 2016-06-22 | Release date: | 2017-05-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Single Disulfide-Directed beta-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry, 56, 2017
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1YWR
| Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor | Descriptor: | 4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE, Mitogen-activated protein kinase 14 | Authors: | Golebiowski, A, Townes, J.A, Laufersweiler, M.J, Brugel, T.A, Clark, M.P, Clark, C.M, Djung, J.F, Laughlin, S.K, Sabat, M.P, Bookland, R.G, Vanrens, J.C, De, B, Hsieh, L.C, Janusz, M.J, Walter, R.L, Webster, M.E, Mekel, M.J. | Deposit date: | 2005-02-18 | Release date: | 2005-05-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The development of monocyclic pyrazolone based cytokine synthesis inhibitors. Bioorg.Med.Chem.Lett., 15, 2005
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6DUW
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6DV1
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1PQ6
| HUMAN LXR BETA HORMONE RECEPTOR / GW3965 COMPLEX | Descriptor: | ISOPROPYL ALCOHOL, Oxysterols receptor LXR-beta, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid | Authors: | Farnegardh, M, Bonn, T, Sun, S, Ljunggren, J, Ahola, H, Wilhelmsson, A, Gustafsson, J.-A, Carlquist, M. | Deposit date: | 2003-06-18 | Release date: | 2003-09-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J.Biol.Chem., 278, 2003
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1PQC
| HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 | Descriptor: | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Oxysterols receptor LXR-beta | Authors: | Farnegardh, M, Bonn, T, Sun, S, Ljunggren, J, Ahola, H, Wilhelmsson, A, Gustafsson, J.-A, Carlquist, M. | Deposit date: | 2003-06-18 | Release date: | 2003-09-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J.Biol.Chem., 278, 2003
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3ZWZ
| Crystal structure of Plasmodium falciparum AMA1 in complex with a 39aa PfRON2 peptide | Descriptor: | APICAL MEMBRANE ANTIGEN 1, AMA1, GLYCEROL, ... | Authors: | Vulliez-Le Normand, B, Tonkin, M.L, Lamarque, M.H, Langer, S, Hoos, S, Roques, M, Saul, F.A, Faber, B.W, Bentley, G.A, Boulanger, M.J, Lebrun, M. | Deposit date: | 2011-08-03 | Release date: | 2012-07-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Functional Insight Into the Malaria Parasite Moving Junction Complex Plos Pathog., 8, 2012
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