1PQ6

HUMAN LXR BETA HORMONE RECEPTOR / GW3965 COMPLEX

Summary for 1PQ6

Entry DOI	10.2210/pdb1pq6/pdb
Descriptor	Oxysterols receptor LXR-beta, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid, ISOPROPYL ALCOHOL, ... (4 entities in total)
Functional Keywords	lxrb+kb043546/way207380/gw3965, transcription regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): P55055
Total number of polymer chains	4
Total formula weight	118095.48
Authors	Farnegardh, M.,Bonn, T.,Sun, S.,Ljunggren, J.,Ahola, H.,Wilhelmsson, A.,Gustafsson, J.-A.,Carlquist, M. (deposition date: 2003-06-18, release date: 2003-09-09, Last modification date: 2024-04-03)
Primary citation	Farnegardh, M.,Bonn, T.,Sun, S.,Ljunggren, J.,Ahola, H.,Wilhelmsson, A.,Gustafsson, J.-A.,Carlquist, M. The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J.Biol.Chem., 278:38821-38828, 2003 Cited by PubMed: 12819202 DOI: 10.1074/jbc.M304842200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation