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2FJP
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BU of 2fjp by Molmil
Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM, ...
Authors:Scapin, G, Patel, S.B, Becker, J.W.
Deposit date:2006-01-03
Release date:2006-07-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J.Med.Chem., 49, 2006
2XUP
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BU of 2xup by Molmil
CRYSTAL STRUCTURE OF the MACHE-Y337A mutant in complex with soaked TZ2PA6 SYN inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE, ...
Authors:Bourne, Y, Radic, Z, Taylor, P, Marchot, P.
Deposit date:2010-10-19
Release date:2010-12-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State
J.Am.Chem.Soc., 132, 2010
8PPR
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BU of 8ppr by Molmil
Structure of the human outer kinetochore KMN network complex
Descriptor: Kinetochore protein Spc24, Kinetochore protein Spc25, Kinetochore scaffold 1, ...
Authors:Yatskevich, S, Barford, D.
Deposit date:2023-07-08
Release date:2024-03-20
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the human outer kinetochore KMN network complex.
Nat.Struct.Mol.Biol., 31, 2024
2Y2U
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BU of 2y2u by Molmil
Nonaged form of Mouse Acetylcholinesterase inhibited by VX-Update
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ACETYLCHOLINESTERASE, ...
Authors:Akfur, C, Artursson, E, Ekstrom, F.
Deposit date:2010-12-16
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Methylphosphonate Adducts of Acetylcholinesterase Investigated by Time Correlated Single Photon Counting and X-Ray Crystallography
To be Published
6WPK
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BU of 6wpk by Molmil
SARM1 Autoinhibited Conformation
Descriptor: NAD(+) hydrolase SARM1
Authors:Xie, T, Bratkowski, M, Bai, X, Sambashivan, S.
Deposit date:2020-04-27
Release date:2020-08-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural and Mechanistic Regulation of the Prodegenerative NAD Hydrolase SARM1
Cell Rep, 32, 2020
6WSL
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BU of 6wsl by Molmil
Cryo-EM structure of VASH1-SVBP bound to microtubules
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Small vasohibin-binding protein, ...
Authors:Li, F, Li, Y, Yu, H.
Deposit date:2020-05-01
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of VASH1-SVBP bound to microtubules.
Elife, 9, 2020
2HGH
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BU of 2hgh by Molmil
Transcription Factor IIIA zinc fingers 4-6 bound to 5S rRNA 55mer (NMR structure)
Descriptor: 55-MER, Transcription factor IIIA, ZINC ION
Authors:Lee, B.M.
Deposit date:2006-06-27
Release date:2006-08-01
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Induced Fit and 'Lock and Key' Recognition of 5 S RNA by Zinc Fingers of Transcription Factor IIIA
J.Mol.Biol., 357, 2006
2HG0
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BU of 2hg0 by Molmil
Structure of the West Nile Virus envelope glycoprotein
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein
Authors:Nybakken, G.E, Nelson, C.A, Chen, B.R, Diamond, M.S, Fremont, D.H.
Deposit date:2006-06-26
Release date:2006-11-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the West Nile virus envelope glycoprotein.
J.Virol., 80, 2006
2HHA
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BU of 2hha by Molmil
The structure of DPP4 in complex with an oxadiazole inhibitor
Descriptor: (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G.
Deposit date:2006-06-28
Release date:2006-09-19
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
6WD5
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BU of 6wd5 by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-08
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
6WDM
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BU of 6wdm by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
6WDD
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BU of 6wdd by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
6WNW
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BU of 6wnw by Molmil
Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA
Descriptor: 16S ribosomal RNA, 23s-5s joint ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Korostelev, A.A, Mankin, A.S, Huang, S, Aleksashin, N.A, Klepacki, D, Reier, K, Kefi, A, Szal, A, Remme, J, Jaeger, L, Vazquez-Laslop, N.
Deposit date:2020-04-23
Release date:2020-06-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly.
Nat Commun, 11, 2020
6WGC
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BU of 6wgc by Molmil
Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
Descriptor: Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ...
Authors:Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WDF
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BU of 6wdf by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
2HI3
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BU of 2hi3 by Molmil
Solution structure of the homeodomain-only protein HOP
Descriptor: Homeodomain-only protein
Authors:Mackay, J.P, Kook, H, Epstein, J.A, Simpson, R.J, Yung, W.W.
Deposit date:2006-06-28
Release date:2007-01-02
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Analysis of the structure and function of the transcriptional coregulator HOP
Biochemistry, 45, 2006
8PK0
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BU of 8pk0 by Molmil
human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7
Descriptor: 16S rRNA + pre-H68-71 segment, 39S ribosomal protein L10, mitochondrial, ...
Authors:Kummer, E, Nguyen, T.G, Ritter, C.
Deposit date:2023-06-23
Release date:2023-12-13
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Nat Commun, 14, 2023
8PHJ
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BU of 8phj by Molmil
cA4-bound Cami1 in complex with 70S ribosome
Descriptor: 16S rRNA, 23S rRNA (2862-MER), 5S rRNA, ...
Authors:Tamulaitiene, G, Mogila, I, Sasnauskas, G, Tamulaitis, G.
Deposit date:2023-06-20
Release date:2023-12-13
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling.
Science, 382, 2023
6YW6
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BU of 6yw6 by Molmil
Cryo-EM structure of the ARP2/3 1B5CL isoform complex.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ARPC1B, Actin-related protein 2, ...
Authors:von Loeffelholz, O, Moores, C, Purkiss, A.
Deposit date:2020-04-29
Release date:2020-07-22
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms.
Biol Open, 9, 2020
8Q0N
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BU of 8q0n by Molmil
HACE1 in complex with RAC1 Q61L
Descriptor: E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ...
Authors:Wolter, M, Duering, J, Dienemann, C, Lorenz, S.
Deposit date:2023-07-28
Release date:2024-01-10
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
2W9Z
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BU of 2w9z by Molmil
Crystal Structure of CDK4 in complex with a D-type cyclin
Descriptor: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1
Authors:Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H.
Deposit date:2009-01-30
Release date:2009-03-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F
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BU of 2w9f by Molmil
Crystal Structure of CDK4 in complex with a D-type cyclin
Descriptor: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1
Authors:Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H.
Deposit date:2009-01-23
Release date:2009-03-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
6X6T
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BU of 6x6t by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
Authors:Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
Deposit date:2020-05-29
Release date:2020-09-02
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of transcription-translation coupling.
Science, 369, 2020
6XTY
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BU of 6xty by Molmil
CryoEM structure of human CMG bound to AND-1 (CMGA)
Descriptor: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W.
Deposit date:2020-01-16
Release date:2020-05-27
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (6.77 Å)
Cite:CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
6YXU
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BU of 6yxu by Molmil
Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State I, primary channel engaged
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Kouba, T, Koval, T, Krasny, L, Dohnalek, J.
Deposit date:2020-05-03
Release date:2020-11-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase.
Nat Commun, 11, 2020

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数据于2024-11-06公开中

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