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8BJX	Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide Descriptor: 1-[(3~{R})-1-(6-nitropyridin-2-yl)pyrrolidin-3-yl]-3-(4-sulfamoylphenyl)thiourea, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2022-11-08 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.283 Å) Cite: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide To Be Published
8CDZ	human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide Descriptor: 1-butyl-3-(4-sulfamoylphenyl)urea, Carbonic anhydrase 1, DIMETHYL SULFOXIDE, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-02-01 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.44 Å) Cite: human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide To Be Published
5L6T	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER Descriptor: 8-azanyl-4-(2-ethylbutoxy)quinoline-2-carbaldehyde, 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, ... Authors: Vallade, M, Langlois d'Estaintot, B, Granier, T, Huc, I. Deposit date: 2016-05-31 Release date: 2017-06-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.65 Å) Cite: CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER To Be Published
5L70	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER Descriptor: 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-[2-(hydroxymethyl)-3-oxidanyl-propoxy]quinoline-2-carbaldehyde, ... Authors: Vallade, M, Langlois d'Estaintot, B, Granier, T, Huc, I. Deposit date: 2016-06-01 Release date: 2017-06-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER To Be Published
4LHI	Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide Descriptor: 5-(phenylsulfonyl)thiophene-2-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2013-07-01 Release date: 2014-07-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide To be Published
8CDX	Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide Descriptor: 1-ethyl-3-(4-sulfamoylphenyl)urea, Carbonic anhydrase 1, ZINC ION Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-02-01 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.335 Å) Cite: Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide To Be Published
7NZT	Crystal structure of chimeric carbonic anhydrase VA with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide Descriptor: 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
7NZU	Crystal structure of chimeric carbonic anhydrase VA with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, BICINE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
7NZS	Crystal structure of chimeric carbonic anhydrase VA with 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide Descriptor: 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
8J2O	Crystal Structure of Human Carbonic Anhydrase II In-complex with Acetohexamide at 2.6 A Resolution Descriptor: 1-cyclohexyl-3-(4-ethanoylphenyl)sulfonyl-urea, Carbonic anhydrase 2, SULFATE ION, ... Authors: Rasheed, S, Huda, N, Choudhary, M.I. Deposit date: 2023-04-14 Release date: 2024-04-24 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of Human Carbonic Anhydrase II In-complex with Acetohexamide at 2.6 A Resolution To Be Published
7NZX	Crystal structure of chimeric carbonic anhydrase VA with 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide Descriptor: 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.33 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
7NZW	Crystal structure of chimeric carbonic anhydrase VA with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide Descriptor: 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
7NZR	Crystal structure of chimeric carbonic anhydrase VA with 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide Descriptor: 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2021-03-24 Release date: 2022-04-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.284 Å) Cite: Crystal structure of chimeric carbonic anhydrase VA To Be Published
8OO8	Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with a Covalent Inhibitor Descriptor: 3-(cyclooctylamino)-4-ethylsulfonyl-2,5,6-tris(fluoranyl)benzenesulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Leitans, J, Tars, K. Deposit date: 2023-04-04 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with a Covalent Inhibitor To Be Published
2FGY	Beta Carbonic Anhydrase from the Carboxysomal Shell of Halothiobacillus neapolitanus (CsoSCA) Descriptor: ZINC ION, carboxysome shell polypeptide Authors: Sawaya, M.R. Deposit date: 2005-12-22 Release date: 2006-01-17 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The Structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two. J.Biol.Chem., 281, 2006
8OGF	Human Carbonic Anhydrase II in complex with 4-(((1-(3-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)benzenesulfonamide Descriptor: 4-[[1-[3-[[(2~{R})-2-oxidanyl-2-[(4~{S},5~{R})-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethyl]amino]propyl]-1,2,3-triazol-4-yl]methylamino]benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-03-20 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.321 Å) Cite: Human Carbonic Anhydrase II in complex with 4-(((1-(3-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)benzenesulfonamide To Be Published
8OTP	Crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(4-sulfamoylbenzoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid Descriptor: 1-cyclopropyl-6-fluoranyl-4-oxidanylidene-7-[4-(4-sulfamoylphenyl)carbonylpiperazin-1-yl]quinoline-3-carboxylic acid, Carbonic anhydrase 2, GLYCEROL, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-04-21 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(4-sulfamoylbenzoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid To Be Published
8OUB	The crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((4-sulfamoylbenzyl)carbamoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid Descriptor: 1-cyclopropyl-6-fluoranyl-4-oxidanylidene-7-[4-[(4-sulfamoylphenyl)methylcarbamoyl]piperazin-1-yl]quinoline-3-carboxylic acid, Carbonic anhydrase 2, ZINC ION Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-04-22 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.178 Å) Cite: The crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((4-sulfamoylbenzyl)carbamoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid To Be Published
8DPO	Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with Acetazolamide Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase, SULFATE ION, ... Authors: Marapaka, A.K, Das, C, Flaherty, D.P, Yadav, R. Deposit date: 2022-07-15 Release date: 2023-07-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with Acetazolamide To Be Published
6ZR8	The crystal structure of 2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II Descriptor: 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide, Carbonic anhydrase 2, ZINC ION Authors: Di Fiore, A, De Simone, G, D'Ambrosio, K. Deposit date: 2020-07-11 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.79 Å) Cite: The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development New J.Chem., 45, 2021
3MF3	Cobalt(II)-Substituted Haemophilus influenzae B-Carbonic Anhydrase Descriptor: ACETATE ION, COBALT (II) ION, Carbonic anhydrase 2 Authors: Hoffmann, K.M, Rowlett, R.S. Deposit date: 2010-04-01 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Structure and Properties of Cobalt(II)-Substituted Haemophilus influenzae B-Carbonic Anhydrase. To be Published
5CLU	THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE Descriptor: (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid, Carbonic anhydrase 2, GLYCEROL, ... Authors: D'Ambrosio, K, De Simone, G. Deposit date: 2015-07-16 Release date: 2015-11-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases. Chemistry, 22, 2016
5LL4	Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide Descriptor: 4-[2-(benzimidazol-1-yl)ethanoyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2016-07-26 Release date: 2017-08-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017
5LL9	Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide Descriptor: 1,2-ETHANEDIOL, 4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide, Carbonic anhydrase 12, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2016-07-27 Release date: 2017-08-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017
5LLA	Crystal structure of human carbonic anhydrase isozyme XIII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide Descriptor: 1,2-ETHANEDIOL, 4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide, CITRIC ACID, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2016-07-27 Release date: 2017-08-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017

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