5CLU

THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE

Summary for 5CLU

Entry DOI	10.2210/pdb5clu/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid, ... (5 entities in total)
Functional Keywords	carbonic anhydrase ii, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29331.37
Authors	D'Ambrosio, K.,De Simone, G. (deposition date: 2015-07-16, release date: 2015-11-11, Last modification date: 2024-01-10)
Primary citation	Langella, E.,D'Ambrosio, K.,D'Ascenzio, M.,Carradori, S.,Monti, S.M.,Supuran, C.T.,De Simone, G. A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases. Chemistry, 22:97-100, 2016 Cited by PubMed: 26507456 DOI: 10.1002/chem.201503748 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation