5CLU

THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE

Summary for 5CLU

DescriptorCarbonic anhydrase 2, ZINC ION, (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid, ... (5 entities in total)
Functional Keywordscarbonic anhydrase ii, lyase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P00918
Total number of polymer chains1
Total molecular weight29331.37
Authors
D'Ambrosio, K.,De Simone, G. (deposition date: 2015-07-16, release date: 2015-11-11, Last modification date: 2016-01-27)
Primary citation
Langella, E.,D'Ambrosio, K.,D'Ascenzio, M.,Carradori, S.,Monti, S.M.,Supuran, C.T.,De Simone, G.
A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases.
Chemistry, 22:97-100, 2016
PubMed: 26507456 (PDB entries with the same primary citation)
DOI: 10.1002/chem.201503748
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.55 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.191500.5%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution