3HZU
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6NAS
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![BU of 6nas by Molmil](/molmil-images/mine/6nas) | Ternary Complex of Ac-Alpha-Actin with Profilin and AcCoA-NAA80 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | Deposit date: | 2018-12-06 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanism of actin N-terminal acetylation. Sci Adv, 6, 2020
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4JQ2
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![BU of 4jq2 by Molmil](/molmil-images/mine/4jq2) | AKR1C2 complex with sulindac | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C2, L(+)-TARTARIC ACID, ... | Authors: | Yosaatmadja, Y, Flanagan, J.U, Squire, C.J. | Deposit date: | 2013-03-19 | Release date: | 2014-04-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis of NSAID selectivity for the aldo-keto reductase 1C family To be Published
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7BE3
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![BU of 7be3 by Molmil](/molmil-images/mine/7be3) | Human Galectin-3 in complex with LacdiNAc | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | Authors: | Trovao, F, Carvalho, A.L. | Deposit date: | 2020-12-22 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. Chemistry, 27, 2021
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6NP0
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![BU of 6np0 by Molmil](/molmil-images/mine/6np0) | Cryo-EM structure of 5HT3A receptor in presence of granisetron | Descriptor: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2019-01-17 | Release date: | 2019-07-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor. Nat Commun, 10, 2019
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4I0U
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![BU of 4i0u by Molmil](/molmil-images/mine/4i0u) | Improved structure of Thermotoga maritima CorA at 2.7 A resolution | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nordin, N, Guskov, A, Phua, T, Sahaf, N, Xia, Y, Lu, S.Y, Eshaghi, H, Eshaghi, S. | Deposit date: | 2012-11-19 | Release date: | 2013-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport. Biochem.J., 451, 2013
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3I49
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4JSI
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![BU of 4jsi by Molmil](/molmil-images/mine/4jsi) | Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-((3-(((3-fluorophenethyl)amino)methyl)phenoxy)methyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[3-({[2-(3-fluorophenyl)ethyl]amino}methyl)phenoxy]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2013-03-22 | Release date: | 2013-08-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorg.Med.Chem., 21, 2013
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6YWY
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![BU of 6ywy by Molmil](/molmil-images/mine/6ywy) | The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site | Descriptor: | 16S rRNA, 23S rRNA, 3-hydroxyisobutyryl-CoA hydrolase, ... | Authors: | Amunts, A, Itoh, Y, Naschberger, A. | Deposit date: | 2020-04-30 | Release date: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi. Nat Commun, 11, 2020
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6O1V
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![BU of 6o1v by Molmil](/molmil-images/mine/6o1v) | Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | Authors: | Zhang, Z, Liu, F, Chen, J, Levit, A, Shoichet, B. | Deposit date: | 2019-02-21 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural identification of a hotspot on CFTR for potentiation. Science, 364, 2019
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7LKP
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![BU of 7lkp by Molmil](/molmil-images/mine/7lkp) | Structure of ATP-free human ABCA4 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Liu, F, Lee, J, Chen, J. | Deposit date: | 2021-02-02 | Release date: | 2021-03-03 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Molecular structures of the eukaryotic retinal importer ABCA4. Elife, 10, 2021
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7BGC
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![BU of 7bgc by Molmil](/molmil-images/mine/7bgc) | human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nachon, F, Salerno, A, Bolognesi, M.L. | Deposit date: | 2021-01-06 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J.Med.Chem., 64, 2021
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3I2F
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![BU of 3i2f by Molmil](/molmil-images/mine/3i2f) | Cocaine Esterase with mutations T172R / G173Q, bound to DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
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7BIN
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![BU of 7bin by Molmil](/molmil-images/mine/7bin) | Salmonella export gate and rod refined in focussed C1 map | Descriptor: | Flagellar basal body rod protein FlgB, Flagellar basal-body rod protein FlgC, Flagellar basal-body rod protein FlgF, ... | Authors: | Johnson, S, Furlong, E, Lea, S.M. | Deposit date: | 2021-01-12 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular structure of the intact bacterial flagellar basal body. Nat Microbiol, 6, 2021
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4JBW
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![BU of 4jbw by Molmil](/molmil-images/mine/4jbw) | Crystal structure of E. coli maltose transporter MalFGK2 in complex with its regulatory protein EIIAglc | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, Glucose-specific phosphotransferase enzyme IIA component, Maltose transport system permease protein MalF, ... | Authors: | Chen, S, Oldham, M.L, Davidson, A.L, Chen, J. | Deposit date: | 2013-02-20 | Release date: | 2013-06-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.913 Å) | Cite: | Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. Nature, 499, 2013
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6NTH
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![BU of 6nth by Molmil](/molmil-images/mine/6nth) | Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (S) Stereoisomer of A-232 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | Authors: | Bester, S.M, Guelta, M.A, Height, J.J, Pegan, S.D. | Deposit date: | 2019-01-29 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | Insights into inhibition of human acetylcholinesterase by Novichok, A-series Nerve Agents To Be Published
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7BC6
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![BU of 7bc6 by Molmil](/molmil-images/mine/7bc6) | Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 | Descriptor: | Proton-coupled folate transporter, nanobody | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | Deposit date: | 2020-12-18 | Release date: | 2021-05-12 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of antifolate recognition and transport by PCFT. Nature, 595, 2021
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7LKZ
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![BU of 7lkz by Molmil](/molmil-images/mine/7lkz) | Structure of ATP-bound human ABCA4 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Liu, F, Lee, J, Chen, J. | Deposit date: | 2021-02-03 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Molecular structures of the eukaryotic retinal importer ABCA4. Elife, 10, 2021
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7C24
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![BU of 7c24 by Molmil](/molmil-images/mine/7c24) | Glycosidase F290Y at pH8.0 | Descriptor: | AMMONIUM ION, GLYCEROL, Isomaltose glucohydrolase | Authors: | Tagami, T, Kikuchi, A, Okuyama, M, Kimura, A. | Deposit date: | 2020-05-07 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural insights reveal the second base catalyst of isomaltose glucohydrolase. Febs J., 289, 2022
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3HSN
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![BU of 3hsn by Molmil](/molmil-images/mine/3hsn) | Ternary structure of neuronal nitric oxide synthase with NHA and CO bound | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, CARBON MONOXIDE, ... | Authors: | Doukov, T, Li, H, Soltis, M, Poulos, T.L. | Deposit date: | 2009-06-10 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands. Biochemistry, 48, 2009
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7C25
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![BU of 7c25 by Molmil](/molmil-images/mine/7c25) | Glycosidase Wild Type at pH8.0 | Descriptor: | AMMONIUM ION, CITRIC ACID, GLYCEROL, ... | Authors: | Tagami, T, Kikuchi, A, Okuyama, M, Kimura, A. | Deposit date: | 2020-05-07 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.505 Å) | Cite: | Structural insights reveal the second base catalyst of isomaltose glucohydrolase. Febs J., 289, 2022
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7BL4
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![BU of 7bl4 by Molmil](/molmil-images/mine/7bl4) | in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Hilal, T, Nikolay, R, Spahn, C.M.T. | Deposit date: | 2021-01-18 | Release date: | 2021-05-12 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7BC7
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![BU of 7bc7 by Molmil](/molmil-images/mine/7bc7) | Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed | Descriptor: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Proton-coupled folate transporter, nanobody | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | Deposit date: | 2020-12-18 | Release date: | 2021-05-12 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of antifolate recognition and transport by PCFT. Nature, 595, 2021
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6NWA
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![BU of 6nwa by Molmil](/molmil-images/mine/6nwa) | The structure of the photosystem I IsiA super-complex | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Toporik, H, Li, J, Williams, D, Chiu, P.L, Mazor, Y. | Deposit date: | 2019-02-06 | Release date: | 2019-05-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | The structure of the stress-induced photosystem I-IsiA antenna supercomplex. Nat.Struct.Mol.Biol., 26, 2019
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6ZG0
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![BU of 6zg0 by Molmil](/molmil-images/mine/6zg0) | SARM1 SAM1-2 domains | Descriptor: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y. | Deposit date: | 2020-06-18 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural basis for SARM1 inhibition and activation under energetic stress. Elife, 9, 2020
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