3ACL
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![BU of 3acl by Molmil](/molmil-images/mine/3acl) | Crystal Structure of Human Pirin in complex with Triphenyl Compound | Descriptor: | FE (II) ION, N-{[4-(benzyloxy)phenyl](methyl)-lambda~4~-sulfanylidene}-4-methylbenzenesulfonamide, Pirin | Authors: | Okumura, H, Miyazaki, I, Simizu, S, Osada, H. | Deposit date: | 2010-01-05 | Release date: | 2010-08-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A small-molecule inhibitor shows that pirin regulates migration of melanoma cells Nat.Chem.Biol., 6, 2010
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3ALC
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![BU of 3alc by Molmil](/molmil-images/mine/3alc) | ETHANOL REGULON TRANSCRIPTIONAL ACTIVATOR DNA-BINDING DOMAIN FROM ASPERGILLUS NIDULANS | Descriptor: | PROTEIN (ETHANOL REGULON TRANSCRIPTIONAL ACTIVATOR), ZINC ION | Authors: | Cerdan, R, Cahuzac, B, Felenbok, B, Guittet, E. | Deposit date: | 1999-03-11 | Release date: | 2000-05-15 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | NMR solution structure of AlcR (1-60) provides insight in the unusual DNA binding properties of this zinc binuclear cluster protein. J.Mol.Biol., 295, 2000
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5V95
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1YAZ
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![BU of 1yaz by Molmil](/molmil-images/mine/1yaz) | AZIDE-BOUND YEAST CU(II)/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE | Descriptor: | AZIDE ION, COPPER (II) ION, PROTEIN (CU/ZN SUPEROXIDE DISMUTASE), ... | Authors: | Hart, P.J, Balbirnie, M.M, Ogihara, N.L, Nersissian, A.M, Weiss, M.S, Valentine, J.S, Eisenberg, D. | Deposit date: | 1998-12-23 | Release date: | 2000-01-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A structure-based mechanism for copper-zinc superoxide dismutase. Biochemistry, 38, 1999
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6D4P
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![BU of 6d4p by Molmil](/molmil-images/mine/6d4p) | Ube2D1 in complex with ubiquitin variant Ubv.D1.1 | Descriptor: | Ubiquitin Variant Ubv.D1.1, Ubiquitin-conjugating enzyme E2 D1 | Authors: | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-18 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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6WGG
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![BU of 6wgg by Molmil](/molmil-images/mine/6wgg) | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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2ZQT
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5ZJR
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![BU of 5zjr by Molmil](/molmil-images/mine/5zjr) | Structure of AbdB/Exd complex bound to a 'Magenta14' DNA sequence | Descriptor: | DNA (5'-D(*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*C)-3'), Homeobox protein abdominal-B, ... | Authors: | Zeiske, T, Baburajendran, N, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G. | Deposit date: | 2018-03-22 | Release date: | 2018-08-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites. Cell Rep, 24, 2018
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6BVA
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![BU of 6bva by Molmil](/molmil-images/mine/6bva) | |
2Z7F
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2QXF
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6BYH
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6BOD
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![BU of 6bod by Molmil](/molmil-images/mine/6bod) | TBK1 in complex with ethyl ester analog of amlexanox | Descriptor: | Serine/threonine-protein kinase TBK1, ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate | Authors: | Beyett, T.S, Tesmer, J.J.G. | Deposit date: | 2017-11-19 | Release date: | 2018-09-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.197 Å) | Cite: | Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94, 2018
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2ZR6
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1XEC
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![BU of 1xec by Molmil](/molmil-images/mine/1xec) | Dimeric bovine tissue-extracted decorin, crystal form 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Decorin | Authors: | Scott, P.G, McEwan, P.A, Dodd, C.M, Bergmann, E.M, Bishop, P.N, Bella, J. | Deposit date: | 2004-09-09 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan Proc.Natl.Acad.Sci.USA, 101, 2004
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6WEL
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![BU of 6wel by Molmil](/molmil-images/mine/6wel) | Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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1XHN
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2ZOC
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![BU of 2zoc by Molmil](/molmil-images/mine/2zoc) | Crystal structure of recombinant human annexin IV | Descriptor: | Annexin A4, CALCIUM ION | Authors: | Konno, M, Kaneko-Kanzaki, Y, Fushinobu-Okushi, N, Mochizuki, K, Uchikaw, E, Satoh, A, Aikawa, K. | Deposit date: | 2008-05-08 | Release date: | 2009-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The comparison of the loop structure of membrane binding sites between human and bovine annexin IV To be Published
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5UQ1
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2ZQS
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6CQ0
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![BU of 6cq0 by Molmil](/molmil-images/mine/6cq0) | TBK1 in Complex with Dimethyl Amino Analog of Amlexanox | Descriptor: | 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 | Authors: | Beyett, T.S, Tesmer, J.J.G. | Deposit date: | 2018-03-14 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
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1YKR
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![BU of 1ykr by Molmil](/molmil-images/mine/1ykr) | Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor | Descriptor: | 4-{[6-(2,6-DICHLOROBENZOYL)IMIDAZO[1,2-A]PYRIDIN-2-YL]AMINO}BENZENESULFONAMIDE, Cell division protein kinase 2 | Authors: | Hamdouchi, C, Zhong, B, Mendoza, J, Jaramillo, C, Zhang, F, Brooks, H.B. | Deposit date: | 2005-01-18 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases Bioorg.Med.Chem.Lett., 15, 2005
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6DA1
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![BU of 6da1 by Molmil](/molmil-images/mine/6da1) | ETS1 in complex with synthetic SRR mimic | Descriptor: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | Authors: | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | Deposit date: | 2018-05-01 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.000127 Å) | Cite: | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
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2VUH
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2XGX
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![BU of 2xgx by Molmil](/molmil-images/mine/2xgx) | Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative) | Descriptor: | 2-OXOGLUTARIC ACID, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLOBAL NITROGEN REGULATOR, ... | Authors: | Llacer, J.L, Castells, M.A, Rubio, V. | Deposit date: | 2010-06-08 | Release date: | 2010-08-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii. Proc.Natl.Acad.Sci.USA, 107, 2010
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