PDB: 1334 resultsInfo pagesStatus searchChemie searchBIRD

---

1CCS	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-12-09 Release date: 1995-02-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995
1BN4	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN1	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNQ	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-02-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1CVD	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-06-21 Release date: 1994-12-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CVH	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-11-16 Release date: 1995-02-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CNW	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS Descriptor: AMINOMETHYLENECARBONYLAMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Boriack, P.A, Christianson, D.W. Deposit date: 1995-07-21 Release date: 1995-11-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
1CNB	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES Descriptor: BETA-MERCAPTOETHANOL, CARBONIC ANHYDRASE II Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-06-13 Release date: 1994-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CNJ	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1995-04-03 Release date: 1995-07-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site J.Am.Chem.Soc., 117, 1995
1CIM	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS Descriptor: (4S-TRANS)-4-(AMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO (2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... Authors: Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N. Deposit date: 1993-10-20 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Protein Sci., 3, 1994
1CVE	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-06-21 Release date: 1994-11-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1BIC	CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... Authors: Xue, Y, Vidgren, J, Svensson, L.A, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-01 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-. Proteins, 15, 1993
1CNC	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-06-13 Release date: 1994-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CVB	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1993-02-04 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. J.Biol.Chem., 268, 1993
1CNI	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1995-04-03 Release date: 1995-07-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site J.Am.Chem.Soc., 117, 1995
1CVF	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE Descriptor: CARBONIC ANHYDRASE II Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-06-21 Release date: 1994-11-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
4N0X	Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide Descriptor: Carbonic anhydrase 2, ZINC ION, thiophene-2-sulfonamide Authors: Fisher, S.Z, Williams, R.F. Deposit date: 2013-10-02 Release date: 2014-01-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide To be Published
4MO8	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide Descriptor: Carbonic anhydrase 2, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide, ZINC ION Authors: Alterio, V, De Simone, G. Deposit date: 2013-09-11 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. J.Med.Chem., 56, 2013
4Q08	Crystal structure of chimeric carbonic anhydrase XII with inhibitor Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, BICINE, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-04-01 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4PZH	Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide Descriptor: 1,2-ETHANEDIOL, 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-03-31 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.06 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4Q0L	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor Descriptor: 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ZINC ION Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-04-02 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4Q7W	Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II Descriptor: 1-hydroxy-6-methylpyridine-2(1H)-thione, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Martin, D.P, Cohen, S.M. Deposit date: 2014-04-25 Release date: 2015-03-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Exploring the influence of the protein environment on metal-binding pharmacophores. J.Med.Chem., 57, 2014
4MTY	Structure at 1A resolution of a helical aromatic foldamer-protein complex. Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, GLYCEROL, ... Authors: Ogayone, T, Buratto, J, Langlois D'Estaintot, B, Stupfel, M, Granier, T, Gallois, B, Huc, Y. Deposit date: 2013-09-20 Release date: 2013-12-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1 Å) Cite: Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 a resolution. Angew.Chem.Int.Ed.Engl., 53, 2014
4PYX	Crystal structure of human carbonic anhydrase isozyme II with inhibitor Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, Carbonic anhydrase 2, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-03-28 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014

<37383940414243444546474849505152>