6YKH

Metala-Carborane di-ethyl-sulfonamide (cis isomer) in complex with CA IX mimic

Summary for 6YKH

• Entry DOI: 10.2210/pdb6ykh/pdb
• Related: 6YJ3 6YKC
• Descriptor: Carbonic anhydrase 2, ZINC ION, Metala-Carborane di-ethyl-sulfonamide, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase, ca inhibitor, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29787.17

Authors

Kugler, M.,Brynda, J.,Pospisilova, K.,Rezacova, P. (deposition date: 2020-04-06, release date: 2020-09-09, Last modification date: 2024-01-24)

• Primary citation: Gruner, B.,Kugler, M.,El Anwar, S.,Holub, J.,Nekvinda, J.,Bavol, D.,Ruzickova, Z.,Pospisilova, K.,Fabry, M.,Kral, V.,Brynda, J.,Rezacova, P.; Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.; Chempluschem, 86:352-363, 2021; PubMed: 32955786; DOI: 10.1002/cplu.202000574

Experimental method

X-RAY DIFFRACTION (1.1 Å)