6YKC
Metala-Carborane di-ethyl-sulfonamide (trans isomer) in complex with CA IX mimic
Summary for 6YKC
| Entry DOI | 10.2210/pdb6ykc/pdb |
| Related | 6Y3J |
| Descriptor | Carbonic anhydrase 2, ZINC ION, Metala-Carborane di-ethyl-sulfonamide, ... (5 entities in total) |
| Functional Keywords | carbonic anhydrase, ca inhibitor, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 30302.00 |
| Authors | Kugler, M.,Brynda, J.,Pospisilova, K.,Rezacova, P. (deposition date: 2020-04-06, release date: 2020-09-09, Last modification date: 2024-01-24) |
| Primary citation | Gruner, B.,Kugler, M.,El Anwar, S.,Holub, J.,Nekvinda, J.,Bavol, D.,Ruzickova, Z.,Pospisilova, K.,Fabry, M.,Kral, V.,Brynda, J.,Rezacova, P. Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX. Chempluschem, 86:352-363, 2021 Cited by PubMed: 32955786DOI: 10.1002/cplu.202000574 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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