6YOI
Meta-Carborane di-propyl-sulfonamide in complex with CA IX mimic
Summary for 6YOI
| Entry DOI | 10.2210/pdb6yoi/pdb |
| Related | 6YO2 6YO4 6YO7 |
| Descriptor | Carbonic anhydrase 2, ZINC ION, Meta-Carborane di-propyl-sulfonamide, ... (4 entities in total) |
| Functional Keywords | carbonic anhydrase, ca inhibitor, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29642.76 |
| Authors | Kugler, M.,Brynda, J.,Pospisilova, K.,Rezacova, P. (deposition date: 2020-04-14, release date: 2020-08-19, Last modification date: 2024-01-24) |
| Primary citation | Nekvinda, J.,Kugler, M.,Holub, J.,El Anwar, S.,Brynda, J.,Pospisilova, K.,Ruzickova, Z.,Rezacova, P.,Gruner, B. Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme. Chemistry, 26:16541-16553, 2020 Cited by PubMed: 32757220DOI: 10.1002/chem.202002809 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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