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3A7V	Crystal Structure of Trypsin complexed with 3-formylbenzimidamide Descriptor: 3-formylbenzenecarboximidamide, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A87	Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 5 minutes) Descriptor: (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A7T	Crystal Structure of Trypsin complexed with 4-formylbenzimidamide Descriptor: 4-formylbenzenecarboximidamide, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A83	Crystal Structure of Trypsin complexed with pre-synthesized (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide Descriptor: (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.78 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A82	Crystal Structure of Trypsin complexed with pre-synthesized (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid Descriptor: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A8D	Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (under aniline-free condition) Descriptor: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A85	Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 15 seconds) Descriptor: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ... Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A80	Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid (soaking 40seconds) Descriptor: (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid, CALCIUM ION, Cationic trypsin Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.75 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
3A8C	Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking with mixture of [(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid] and [(E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid]) Descriptor: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin Authors: Yamane, J, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.85 Å) Cite: In-Crystal Chemical Ligation for Drug Discovery To be Published
1DWE	Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors Descriptor: ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
2G55	Anomalous substructure of trypsin (P3121) Descriptor: CALCIUM ION, CHLORIDE ION, Cationic trypsin Authors: Mueller-Dieckmann, C, Weiss, M.S. Deposit date: 2006-02-22 Release date: 2007-02-20 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
1MCV	Crystal Structure Analysis of a Hybrid Squash Inhibitor in Complex with Porcine Pancreatic Elastase Descriptor: CALCIUM ION, Elastase 1, HEI-TOE I, ... Authors: Ay, J, Hilpert, K, Krauss, N, Schneider-Mergener, J, Hoehne, W. Deposit date: 2002-08-06 Release date: 2003-02-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
1UMA	ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUDIN I, ... Authors: Nardini, M, Pesce, A, Rizzi, M, Casale, E, Ferraccioli, R, Balliano, G, Milla, P, Ascenzi, P, Bolognesi, M. Deposit date: 1996-03-26 Release date: 1996-11-08 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study. J.Mol.Biol., 258, 1996
2D8W	Structure of HYPER-VIL-trypsin Descriptor: CALCIUM ION, Cationic trypsin, IODIDE ION Authors: Miyatake, H, Hasegawa, T, Yamano, A. Deposit date: 2005-12-08 Release date: 2006-07-11 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2 Å) Cite: New methods to prepare iodinated derivatives by vaporizing iodine labelling (VIL) and hydrogen peroxide VIL (HYPER-VIL) ACTA CRYSTALLOGR.,SECT.D, 62, 2006
1DWB	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.16 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1DWD	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1DWC	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
2AIH	1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris. Descriptor: Bowman-Birk type protease inhibitor, LCTI, CHLORIDE ION Authors: Ragg, E.M, Galbusera, V, Scarafoni, A, Negri, A, Tedeschi, G, Consonni, A, Sessa, F, Duranti, M. Deposit date: 2005-07-29 Release date: 2006-08-01 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Inhibitory properties and solution structure of a potent Bowman-Birk protease inhibitor from lentil (Lens culinaris, L) seeds. Febs J., 273, 2006
1CO7	R117H mutant rat anionic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, TRYPSIN II Authors: Stamper, G.F, Ringe, D, Hedstrom, L. Deposit date: 1999-06-07 Release date: 2003-01-07 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite:
1FJS	CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA Descriptor: CALCIUM ION, CHLORIDE ION, COAGULATION FACTOR XA, ... Authors: Adler, M, Whitlow, M. Deposit date: 2000-08-08 Release date: 2000-10-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa. Biochemistry, 39, 2000
2G52	Anomalous substructure of trypsin (P21) Descriptor: SULFATE ION, Trypsin Authors: Mueller-Dieckmann, C, Weiss, M.S. Deposit date: 2006-02-22 Release date: 2007-02-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.84 Å) Cite: On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
4TTK	Racemic structure of Sunflower Trypsin Inhibitor-1 (SFTI-1) Descriptor: Sunflower Trypsin Inhibitor-1 (SFTI-1) (D-form) Authors: Wang, C.K, King, G.J, Craik, D.J. Deposit date: 2014-06-22 Release date: 2014-09-10 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.2502 Å) Cite: Racemic and Quasi-Racemic X-ray Structures of Cyclic Disulfide-Rich Peptide Drug Scaffolds. Angew.Chem.Int.Ed.Engl., 53, 2014
2G51	anomalous substructure of trypsin (p1) Descriptor: CHLORIDE ION, Trypsin Authors: Mueller-Dieckmann, C, Weiss, M.S. Deposit date: 2006-02-22 Release date: 2007-02-20 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.84 Å) Cite: On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
1TNL	PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS Descriptor: CALCIUM ION, TRANS-2-PHENYLCYCLOPROPYLAMINE, TRYPSIN Authors: Kurinov, I, Harrison, R.W. Deposit date: 1994-07-21 Release date: 1994-11-30 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Prediction of new serine proteinase inhibitors. Nat.Struct.Biol., 1, 1994
1O2K	Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors Descriptor: 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-6-ISOBUTOXYBENZENOLATE, BETA-TRYPSIN, CALCIUM ION, ... Authors: Katz, B.A, Elrod, K, Verner, E, Mackman, R.L, Luong, C, Shrader, W, Sendzik, M, Spencer, J.R, Sprengeler, P.A, Kolesnikov, A, Tai, W.F, Hui, H, Breitenbucher, G, Allen, D, Janc, J. Deposit date: 2003-03-06 Release date: 2003-05-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors J.Mol.Biol., 329, 2003

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