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4RXA
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BU of 4rxa by Molmil
Crystal structure of human farnesyl diphosphate synthase in complex with BPH-1358
Descriptor: Farnesyl pyrophosphate synthase, N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]biphenyl-4,4'-dicarboxamide, PHOSPHATE ION
Authors:Liu, Y.-L, Cao, R, Wang, Y, Oldfield, E.
Deposit date:2014-12-09
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
4RYP
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BU of 4ryp by Molmil
Crystal Structure of T. Brucei Farnesyl Diphosphate Synthase
Descriptor: Farnesyl pyrophosphate synthase
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2014-12-16
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
4RXD
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BU of 4rxd by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Risedronate
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2014-12-10
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
1ZW5
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BU of 1zw5 by Molmil
X-ray structure of Farnesyl diphosphate synthase protein
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ZOLEDRONIC ACID, ...
Authors:Kavanagh, K.L, Guo, K, Wu, X, von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2005-06-03
Release date:2005-06-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
4RXE
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BU of 4rxe by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-14
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, {[(3-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2014-12-10
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
4RXC
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BU of 4rxc by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Homorisedronate BPH-6
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, [1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid)
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2014-12-09
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
6B02
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BU of 6b02 by Molmil
Crystal structure of CfFPPS2 (apo form), a lepidopteran type-II farnesyl diphosphate synthase
Descriptor: Farnesyl diphosphate synthase
Authors:Picard, M.-E, Cusson, M, Shi, R.
Deposit date:2017-09-13
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.
Insect Biochem. Mol. Biol., 92, 2017
6B07
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BU of 6b07 by Molmil
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [1-phosphono-2-(1-propylpyridin-2-yl)ethyl]phosphonic acid (inhibitor 1d)
Descriptor: 1,2-ETHANEDIOL, 2-(2,2-diphosphonoethyl)-1-propylpyridin-1-ium, Farnesyl diphosphate synthase, ...
Authors:Picard, M.-E, Cusson, M, Shi, R.
Deposit date:2017-09-13
Release date:2017-12-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.
Insect Biochem. Mol. Biol., 92, 2017
6B06
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BU of 6b06 by Molmil
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with IPP and [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Descriptor: 2-(2,2-diphosphonoethyl)-1-methylpyridin-1-ium, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl diphosphate synthase, ...
Authors:Picard, M.-E, Cusson, M, Shi, R.
Deposit date:2017-09-13
Release date:2017-12-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.
Insect Biochem. Mol. Biol., 92, 2017
4UMJ
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BU of 4umj by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound ibandronic acid molecules.
Descriptor: GERANYLTRANSTRANSFERASE, IBANDRONATE, MAGNESIUM ION
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2014-05-18
Release date:2015-03-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa.
Acta Crystallogr.,Sect.D, 71, 2015
1YHM
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BU of 1yhm by Molmil
Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, MAGNESIUM ION, ...
Authors:Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
5ZE6
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BU of 5ze6 by Molmil
CRYSTAL STRUCTURE OF OCTAPRENYL PYROPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI WITH BPH-981
Descriptor: 2-hydroxy-6-(tetradecyloxy)benzoic acid, MAGNESIUM ION, Octaprenyl diphosphate synthase
Authors:Han, X, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T.
Deposit date:2018-02-26
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
J.Med.Chem., 62, 2019
5ZLF
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BU of 5zlf by Molmil
CRYSTAL STRUCTURE OF OCTAPRENYL PYROPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI WITH ligand BPH-629
Descriptor: MAGNESIUM ION, Octaprenyl diphosphate synthase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
Authors:Han, X, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T.
Deposit date:2018-03-27
Release date:2019-03-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
J.Med.Chem., 62, 2019
5JV0
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BU of 5jv0 by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038
Descriptor: Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid
Authors:Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M.
Deposit date:2016-05-10
Release date:2017-03-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5KSX
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BU of 5ksx by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072
Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid
Authors:Park, J, Matralis, A, Tsantrizos, Y.S, Berghuis, A.M.
Deposit date:2016-07-10
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5JA0
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BU of 5ja0 by Molmil
Crystal structure of human FPPS with allosterically bound FPP
Descriptor: FARNESYL DIPHOSPHATE, Farnesyl pyrophosphate synthase, PHOSPHATE ION
Authors:Park, J, Zielinski, M, Tsantrizos, Y.S, Berghuis, A.M.
Deposit date:2016-04-11
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.
Nat Commun, 8, 2017
5JFQ
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BU of 5jfq by Molmil
Geranylgeranyl Pyrophosphate Synthetase from archaeon Geoglobus acetivorans
Descriptor: Geranylgeranyl Pyrophosphate Synthetase
Authors:Petrova, T, Boyko, K.M, Nikolaeva, A.Y, Stekhanova, T.N, Mardanov, A.V, Rakitin, A.L, Ravin, N.V, Popov, V.O.
Deposit date:2016-04-19
Release date:2017-05-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans.
Extremophiles, 22, 2018
2AZK
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BU of 2azk by Molmil
Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase
Descriptor: Geranylgeranyl pyrophosphate synthetase
Authors:Sun, H.Y, Ko, T.P, Kuo, C.J, Guo, R.T, Chou, C.C, Liang, P.H, Wang, A.H.J.
Deposit date:2005-09-12
Release date:2006-03-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures
J.Bacteriol., 187, 2005
2AZL
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BU of 2azl by Molmil
Crystal structure for the mutant F117E of Thermotoga maritima octaprenyl pyrophosphate synthase
Descriptor: octoprenyl-diphosphate synthase
Authors:Sun, H.Y, Ko, T.P, Kuo, C.J, Guo, R.T, Chou, C.C, Liang, P.H, Wang, A.H.
Deposit date:2005-09-12
Release date:2006-03-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures
J.Bacteriol., 187, 2005
1YV5
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BU of 1yv5 by Molmil
Human farnesyl diphosphate synthase complexed with Mg and risedronate
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthetase, MAGNESIUM ION, ...
Authors:Kavanagh, K.L, Guo, K, Von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2005-02-15
Release date:2005-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
6B04
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BU of 6b04 by Molmil
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Descriptor: 1,2-ETHANEDIOL, 2-(2,2-diphosphonoethyl)-1-methylpyridin-1-ium, Farnesyl diphosphate synthase, ...
Authors:Picard, M.-E, Cusson, M, Shi, R.
Deposit date:2017-09-13
Release date:2017-12-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.
Insect Biochem. Mol. Biol., 92, 2017
3EZ3
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BU of 3ez3 by Molmil
Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound
Descriptor: 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ...
Authors:Wernimont, A.K, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC)
Deposit date:2008-10-22
Release date:2008-12-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound
TO BE PUBLISHED
2OPN
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BU of 2opn by Molmil
Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527
Descriptor: Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Cao, R, Gao, Y.G, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2007-01-29
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bisphosphonates: Teaching Old Drugs with New Tricks
To be Published
2P1C
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BU of 2p1c by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-210
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, Farnesyl pyrophosphate synthase, ...
Authors:Cao, R, Gao, Y, Oldfield, E.
Deposit date:2007-03-04
Release date:2008-03-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Proteins, 73, 2008
2RAH
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BU of 2rah by Molmil
Human FDPS synthase in complex with novel inhibitor
Descriptor: Farnesyl pyrophosphate synthetase, MAGNESIUM ION, SULFATE ION, ...
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2007-09-15
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human FDPS synthase in complex with novel inhibitor
To be Published

221716

数据于2024-06-26公开中

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