4RXA

Crystal structure of human farnesyl diphosphate synthase in complex with BPH-1358

Summary for 4RXA

Entry DOI	10.2210/pdb4rxa/pdb
Descriptor	Farnesyl pyrophosphate synthase, N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]biphenyl-4,4'-dicarboxamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	prenylation, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40653.27
Authors	Liu, Y.-L.,Cao, R.,Wang, Y.,Oldfield, E. (deposition date: 2014-12-09, release date: 2015-04-15, Last modification date: 2024-02-28)
Primary citation	Liu, Y.L.,Cao, R.,Wang, Y.,Oldfield, E. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett, 6:349-354, 2015 Cited by PubMed: 25815158 DOI: 10.1021/ml500528x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation