7L6X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l6x by Molmil](/molmil-images/mine/7l6x) | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to GNE-371 | Descriptor: | 1,2-ETHANEDIOL, 6-(but-3-en-1-yl)-4-[1-methyl-6-(morpholine-4-carbonyl)-1H-benzimidazol-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one, Transcription initiation factor TFIID subunit 1 | Authors: | Karim, M.R, Schonbrunn, E. | Deposit date: | 2020-12-24 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
|
|
3BAV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bav by Molmil](/molmil-images/mine/3bav) | |
3BB2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bb2 by Molmil](/molmil-images/mine/3bb2) | |
1K5K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1k5k by Molmil](/molmil-images/mine/1k5k) | Homonuclear 1H Nuclear Magnetic Resonance Assignment and Structural Characterization of HIV-1 Tat Mal Protein | Descriptor: | TAT protein | Authors: | Gregoire, C, Peloponese, J.M, Esquieu, D, Opi, S, Campbell, G, Solomiac, M, Lebrun, E, Lebreton, J, Loret, E.P. | Deposit date: | 2001-10-11 | Release date: | 2002-06-19 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Homonuclear (1)H-NMR assignment and structural characterization of human immunodeficiency virus type 1 Tat Mal protein. Biopolymers, 62, 2001
|
|
1K7A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1k7a by Molmil](/molmil-images/mine/1k7a) | Ets-1(331-440)+GGAG duplex | Descriptor: | C-ets-1 Protein, DNA (5'-D(*CP*AP*CP*AP*TP*CP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*GP*AP*TP*GP*T)-3') | Authors: | Garvie, C.W, Hagman, J, Wolberger, C. | Deposit date: | 2001-10-18 | Release date: | 2002-01-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural studies of Ets-1/Pax5 complex formation on DNA. Mol.Cell, 8, 2001
|
|
1K78
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1k78 by Molmil](/molmil-images/mine/1k78) | Pax5(1-149)+Ets-1(331-440)+DNA | Descriptor: | C-ets-1 Protein, Paired Box Protein Pax5, Pax5/Ets Binding Site on the mb-1 promoter | Authors: | Garvie, C.W, Hagman, J, Wolberger, C. | Deposit date: | 2001-10-18 | Release date: | 2002-01-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural studies of Ets-1/Pax5 complex formation on DNA. Mol.Cell, 8, 2001
|
|
1ZS4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zs4 by Molmil](/molmil-images/mine/1zs4) | Structure of bacteriophage lambda cII protein in complex with DNA | Descriptor: | DNA - 27mer, Regulatory protein CII | Authors: | Jain, D, Kim, Y, Maxwell, K.L, Beasley, S, Gussin, G.N, Edwards, A.M, Darst, S.A. | Deposit date: | 2005-05-23 | Release date: | 2005-08-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of Bacteriophage lambdacII and Its DNA Complex. Mol.Cell, 19, 2005
|
|
3BA7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ba7 by Molmil](/molmil-images/mine/3ba7) | |
5HC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hc1 by Molmil](/molmil-images/mine/5hc1) | |
1PUF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1puf by Molmil](/molmil-images/mine/1puf) | Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA | Descriptor: | 5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*CP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3', Homeobox protein Hox-A9, ... | Authors: | Laronde-Leblanc, N.A, Wolberger, C. | Deposit date: | 2003-06-24 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR Genes Dev., 17, 2003
|
|
7M2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m2g by Molmil](/molmil-images/mine/7m2g) | INTERLEUKIN-2 (human) mutant P65K, C125S | Descriptor: | GLYCEROL, Interleukin-2, SULFATE ION | Authors: | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | Deposit date: | 2021-03-16 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12, 2021
|
|
5HBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hbz by Molmil](/molmil-images/mine/5hbz) | |
1IG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ig7 by Molmil](/molmil-images/mine/1ig7) | Msx-1 Homeodomain/DNA Complex Structure | Descriptor: | 5'-D(*CP*AP*CP*TP*AP*AP*TP*TP*GP*AP*AP*GP*G)-3', 5'-D(P*TP*CP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*TP*GP*AP*C)-3', Homeotic protein Msx-1 | Authors: | Hovde, S, Abate-Shen, C, Geiger, J.H. | Deposit date: | 2001-04-17 | Release date: | 2001-04-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the Msx-1 homeodomain/DNA complex Biochemistry, 40, 2001
|
|
1ODH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1odh by Molmil](/molmil-images/mine/1odh) | Structure of the GCM domain bound to DNA | Descriptor: | 5'-D(*CP*GP*AP*TP*GP*CP*GP*GP*GP*TP *GP*CP*A)-3', 5'-D(*TP*GP*CP*AP*CP*CP*CP*GP*CP*AP *TP*CP*G)-3', MGCM1, ... | Authors: | Cohen, S.X, Muller, C.W. | Deposit date: | 2003-02-19 | Release date: | 2003-04-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal Structure of the Gcm Domain-DNA Complex: A DNA-Binding Domain with a Novel Fold and Mode of Target Site Recognition Embo J., 22, 2003
|
|
3TEI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3tei by Molmil](/molmil-images/mine/3tei) | Crystal structure of human ERK2 complexed with a MAPK docking peptide | Descriptor: | Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2011-08-15 | Release date: | 2012-08-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.404 Å) | Cite: | Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012
|
|
2GPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2gph by Molmil](/molmil-images/mine/2gph) | Docking motif interactions in the MAP kinase ERK2 | Descriptor: | Mitogen-activated protein kinase 1, Tyrosine-protein phosphatase non-receptor type 7 | Authors: | Zhou, T, Sun, L, Humphreys, J, Goldsmith, E.J. | Deposit date: | 2006-04-17 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2. Structure, 14, 2006
|
|
1YW2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yw2 by Molmil](/molmil-images/mine/1yw2) | Mutated Mus Musculus P38 Kinase (mP38) | Descriptor: | 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14 | Authors: | Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J. | Deposit date: | 2005-02-16 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15, 2005
|
|
2Q21
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q21 by Molmil](/molmil-images/mine/2q21) | |
2OQQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2oqq by Molmil](/molmil-images/mine/2oqq) | Crystal structure of HY5 leucine zipper homodimer from Arabidopsis thaliana | Descriptor: | Transcription factor HY5 | Authors: | Yoon, M.-K, Kim, H.M, Choi, G, Lee, J.-O, Choi, B.-S. | Deposit date: | 2007-02-01 | Release date: | 2007-03-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the conformational integrity of the Arabidopsis thaliana HY5 leucine zipper homodimer. J.Biol.Chem., 282, 2007
|
|
1DL6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1dl6 by Molmil](/molmil-images/mine/1dl6) | SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN | Descriptor: | TRANSCRIPTION FACTOR II B (TFIIB), ZINC ION | Authors: | Chen, H.-T, Legault, P, Glushka, J, Omichinski, J.G, Scott, R.A. | Deposit date: | 1999-12-08 | Release date: | 2000-10-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. Protein Sci., 9, 2000
|
|
1MD0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1md0 by Molmil](/molmil-images/mine/1md0) | |
1ENW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1enw by Molmil](/molmil-images/mine/1enw) | |
3PSJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3psj by Molmil](/molmil-images/mine/3psj) | |
4X63
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x63 by Molmil](/molmil-images/mine/4x63) | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH | Descriptor: | Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, Protein arginine N-methyltransferase 5, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2015-05-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
|
|
7S1P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s1p by Molmil](/molmil-images/mine/7s1p) | PRMT5/MEP50 crystal structure with sinefungin bound | Descriptor: | Methylosome protein 50, Protein arginine N-methyltransferase 5, SINEFUNGIN | Authors: | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | Deposit date: | 2021-09-02 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
|
|