PDB: 72308 resultsInfo pagesStatus searchChemie searchBIRD

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2ZT7	Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCINE, Glycyl-tRNA synthetase Authors: Guo, R.T, Yang, X.L, Schimmel, P. Deposit date: 2008-09-19 Release date: 2009-08-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis To be Published
2ZT6	Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Glycyl-tRNA synthetase Authors: Guo, R.T, Yang, X.L, Schimmel, P. Deposit date: 2008-09-19 Release date: 2009-08-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.08 Å) Cite: Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis To be Published
4O2D	Crystal structure of aspartyl-tRNA synthetase from Mycobacterium smegmatis with bound aspartic acid Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ASPARTIC ACID, Aspartate--tRNA ligase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-12-17 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
2VDU	Structure of trm8-trm82, THE YEAST TRNA m7G methylation complex Descriptor: PHOSPHATE ION, TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE, TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE-ASSOCIATED WD REPEAT PROTEIN TRM82 Authors: Leulliot, N, Chaillet, M, Durand, D, Ulryck, N, Blondeau, K, Van Tilbeurgh, H. Deposit date: 2007-10-11 Release date: 2007-12-18 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the Yeast tRNA M7G Methylation Complex. Structure, 16, 2008
6NM4	Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor Descriptor: 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ... Authors: Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC) Deposit date: 2019-01-10 Release date: 2019-02-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Discovery of a chemical probe for PRDM9. Nat Commun, 10, 2019
4C13	x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys Descriptor: CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. Deposit date: 2013-08-09 Release date: 2013-10-02 Last modified: 2021-03-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol., 2021
1ENU	A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase Descriptor: 4-AMINOPHTHALHYDRAZIDE, TRNA-GUANINE TRANSGLYCOSYLASE, ZINC ION Authors: Gradler, U, Gerber, H.D, Goodenough-Lashua, D.M, Garcia, G.A, Ficner, R, Reuter, K, Stubbs, M.T, Klebe, G. Deposit date: 2000-03-21 Release date: 2000-04-19 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. J.Mol.Biol., 306, 2001
4KYY	Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex Descriptor: POTASSIUM ION, RNA 17-mer Authors: Smith, P.C, Shuman, S. Deposit date: 2013-05-29 Release date: 2013-06-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex To be Published
1F3E	A NEW TARGET FOR SHIGELLOSIS: RATIONAL DESIGN AND CRYSTALLOGRAPHIC STUDIES OF INHIBITORS OF TRNA-GUANINE TRANSGLYCOSYLASE Descriptor: 3,5-DIAMINOPHTHALHYDRAZIDE, QUEUINE TRNA-RIBOSYLTRANSFERASE, ZINC ION Authors: Graedler, U, Gerber, H.-D, Goodenough-Lashua, D.M, Garcia, G.A.G, Ficner, R, Reuter, K, Stubbs, M.T, Klebe, G. Deposit date: 2000-06-02 Release date: 2000-06-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. J.Mol.Biol., 306, 2001
4LJ0	Nab2 Zn fingers complexed with polyadenosine Descriptor: ACETATE ION, MAGNESIUM ION, Nab2, ... Authors: Stewart, M, Kuhlmann, S.I, Valkov, E. Deposit date: 2013-07-04 Release date: 2013-10-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers. Nucleic Acids Res., 42, 2014
1SAQ	Crystal Structure of the RNA octamer GIC(GA)GCC Descriptor: 5'-R(*GP*IP*CP*GP*AP*GP*CP*C)-3' Authors: Jang, S.B, Baeyens, K, Jeong, M.S, SantaLucia Jr, J, Turner, D, Holbrook, S.R. Deposit date: 2004-02-09 Release date: 2004-05-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structures of two RNA octamers containing tandem G.A base pairs. Acta Crystallogr.,Sect.D, 60, 2004
2OIY	Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site Descriptor: 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3', MAGNESIUM ION, POTASSIUM ION Authors: Ennifar, E, Walter, P, Dumas, P. Deposit date: 2007-01-12 Release date: 2007-12-25 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Cation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation site. Nucleic Acids Res., 38, 2010
2OJ0	Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site MN soaked Descriptor: 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3', MANGANESE (II) ION, POTASSIUM ION, ... Authors: Ennifar, E, Walter, P, Dumas, P. Deposit date: 2007-01-12 Release date: 2007-12-25 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Cation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation site. Nucleic Acids Res., 38, 2010
1SA9	Crystal Structure of the RNA octamer GGCGAGCC Descriptor: 5'-R(*GP*GP*CP*GP*AP*GP*CP*C)-3' Authors: Jang, S.B, Baeyens, K, Jeong, M.S, SantaLucia Jr, J, Turner, D, Holbrook, S.R. Deposit date: 2004-02-09 Release date: 2004-05-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Structures of two RNA octamers containing tandem G.A base pairs. Acta Crystallogr.,Sect.D, 60, 2004
7F96	Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L95 Descriptor: PROLINE, Proline--tRNA ligase, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide Authors: Mishra, S, Malhotra, N, Manickam, Y, Sharma, A. Deposit date: 2021-07-04 Release date: 2023-01-04 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.577 Å) Cite: PfPRS with ATP binding pocket inhibitor To Be Published
3C8Z	The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Cysteinyl-tRNA synthetase, ... Authors: Tremblay, L.W, Fan, F, Vetting, M.W, Blanchard, J.S. Deposit date: 2008-02-14 Release date: 2008-12-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway. Biochemistry, 47, 2008
4NJC	RNA Polymerase interacting protein YkzG from Geobacillus stearothermophilus Descriptor: Geobacillus stearothermophilus YkzG Authors: Keller, A.N, Lewis, P.J. Deposit date: 2013-11-09 Release date: 2014-08-20 Last modified: 2014-10-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: epsilon, a New Subunit of RNA Polymerase Found in Gram-Positive Bacteria J.Bacteriol., 196, 2014
2JXS	NMR structure of RNA duplex containing single adenosine bulge Descriptor: 5'-R(*CP*GP*CP*UP*CP*UP*CP*UP*GP*C)-3', 5'-R(*GP*CP*AP*GP*AP*AP*GP*AP*GP*CP*G)-3' Authors: Popenda, L, Adamiak, R.W, Gdaniec, Z. Deposit date: 2007-11-29 Release date: 2008-05-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Bulged adenosine influence on the RNA duplex conformation in solution. Biochemistry, 47, 2008
2QEK	HIV-1 subtype F DIS RNA extended duplex form Descriptor: HIV-1 subtype F DIS genomic RNA, MAGNESIUM ION, POTASSIUM ION Authors: Freisz, S, Ennifar, E, Dumas, P. Deposit date: 2007-06-26 Release date: 2008-05-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site. Angew.Chem.Int.Ed.Engl., 47, 2008
2M4K	Solution structure of the delta subunit of RNA polymerase from Bacillus subtilis Descriptor: DNA-directed RNA polymerase subunit delta Authors: Papouskova, V, Novacek, J, Kaderavek, P, Zidek, L, Rabatinova, A, Sanderova, H, Krasny, L, Sklenar, V. Deposit date: 2013-02-07 Release date: 2013-10-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Study of the Partially Disordered Full-Length delta Subunit of RNA Polymerase from Bacillus subtilis. Chembiochem, 14, 2013
1TTO	Crystal structure of the Rnase T1 variant R2 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, RNase T1 Authors: Hahn, U, Czaja, R, Perbandt, M, Betzel, C. Deposit date: 2004-06-23 Release date: 2005-09-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Purine activity of RNase T1RV is further improved by substitution of Trp59 by tyrosine Biochem.Biophys.Res.Commun., 336, 2005
7EAF	Crystal structure of SAM-I riboswitch with the Actinomyces-1 k-turn Descriptor: BARIUM ION, RNA (94-MER), S-ADENOSYLMETHIONINE, ... Authors: Huang, L, Lilley, D.M.J. Deposit date: 2021-03-07 Release date: 2021-06-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules. Nucleic Acids Res., 49, 2021
2YDH	Crystal structure of the SAM-I riboswitch A94G U34 G18U G19U variant in complex with SAM Descriptor: BARIUM ION, S-ADENOSYLMETHIONINE, SAM-I RIBOSWITCH Authors: Schroeder, K.T, Daldrop, P, Lilley, D.M.J. Deposit date: 2011-03-21 Release date: 2011-09-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: RNA Tertiary Interactions in a Riboswitch Stabilize the Structure of a Kink Turn. Structure, 19, 2011
7F9U	Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Halofuginone Descriptor: 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, ... Authors: Manickam, Y, Malhotra, N, Sharma, A. Deposit date: 2021-07-04 Release date: 2022-07-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: TgPRS with double inhibitors To Be Published
7F9R	Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95, L-Proline and Febrifugine Descriptor: 1,2-ETHANEDIOL, 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, CHLORIDE ION, ... Authors: Manickam, Y, Malhotra, N, Sharma, A. Deposit date: 2021-07-04 Release date: 2022-07-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.83 Å) Cite: TgPRS with double inhibitors To Be Published

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