2BD0
 
 | | Chlorobium tepidum Sepiapterin Reductase complexed with NADP and Sepiapterin | | Descriptor: | BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, sepiapterin reductase | | Authors: | Supangat, S, Seo, K.H, Choi, Y.K, Park, Y.S, Lee, K.H. | | Deposit date: | 2005-10-19 | | Release date: | 2005-11-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
J.Biol.Chem., 281, 2006
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3EW3
 | | the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor | | Descriptor: | Prolactin, Prolactin receptor | | Authors: | Broutin, I, Jomain, J.B, England, P, Goffin, V. | | Deposit date: | 2008-10-14 | | Release date: | 2009-11-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
J.Biol.Chem., 285, 2010
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9D4Z
 | | CryoEM structure of PAR1 with endogenous tethered ligand | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha chimera, ... | | Authors: | Lyu, X, Lyu, Z, McGrath, A.P, Kang, Y. | | Deposit date: | 2024-08-13 | | Release date: | 2025-05-07 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2.
Nat Commun, 16, 2025
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9E7R
 | | CryoEM structure of PAR2 with GB88 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha chimera, ... | | Authors: | Lyu, X, Lyu, Z, Malyutin, A.G, McGrath, A.P, Kang, Y. | | Deposit date: | 2024-11-04 | | Release date: | 2025-05-07 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2.
Nat Commun, 16, 2025
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9DUO
 | | Human PELP1-WDR18 complex | | Descriptor: | Proline-, glutamic acid- and leucine-rich protein 1, WD repeat-containing protein 18 | | Authors: | Huang, J, Tong, L. | | Deposit date: | 2024-10-03 | | Release date: | 2025-04-30 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Molecular insights into the overall architecture of human rixosome.
Nat Commun, 16, 2025
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4AQ3
 | | HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR | | Descriptor: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide | | Authors: | Bertrand, J.A, Fasolini, M, Modugno, M. | | Deposit date: | 2012-04-12 | | Release date: | 2012-06-06 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
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9EGO
 | | Cannabinoid receptor 1-Gi complex with novel ligand | | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Tummino, T.A, Iliopoulos-Tsoutsouvas, C, Braz, J.M, O'Brien, E.S, Krishna Kumar, K, Makriyannis, M, Basbaum, A.I, Shoichet, B.K. | | Deposit date: | 2024-11-21 | | Release date: | 2025-04-30 | | Last modified: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.
Nat Commun, 16, 2025
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9D5N
 | | 48-nm doublet microtubule from Trichomonas vaginalis strain G3 | | Descriptor: | Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 45, Cilia- and flagella-associated protein 52, ... | | Authors: | Stevens, A, Zhou, H.Z, Kashyap, S, Crofut, E.J. | | Deposit date: | 2024-08-13 | | Release date: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structures of Native Doublet Microtubules from Trichomonas vaginalis Reveal Parasite-Specific Proteins.
Nat Commun, 16, 2025
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3F1L
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9B1W
 | | HWS19 strain WT mycobacterial ribosome | | Descriptor: | 15S rRNA, 23S rRNA, 50S ribosomal protein L13, ... | | Authors: | Young, I.D, Chen, Y, Javid, B, Fraser, J.S. | | Deposit date: | 2024-03-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Ribosomal RNA methylation by GidB is a capacitor for discrimination of mischarged tRNA
To be published
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2BV5
 | | CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION | | Descriptor: | GLYCEROL, SULFATE ION, TYROSINE-PROTEIN PHOSPHATASE, ... | | Authors: | Debreczeni, J.E, Barr, A.J, Eswaran, J, Smee, C, Burgess, N, Gileadi, O, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Knapp, S. | | Deposit date: | 2005-06-22 | | Release date: | 2005-07-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
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9B1X
 | | HWS19 strain gidB mutant mycobacterial ribosome | | Descriptor: | 16S rRNA, 23S rRNA, 50S ribosomal protein L36, ... | | Authors: | Chen, Y, Young, I.D, Fraser, J.S, Javid, B. | | Deposit date: | 2024-03-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Ribosomal RNA methylation by GidB is a capacitor for discrimination of mischarged tRNA
To be published
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3FH7
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9B24
 | | WT strain gidB mutant mycobacterial ribosome | | Descriptor: | 23S rRNA, 23S rRNA part, 50S ribosomal protein L36, ... | | Authors: | Young, I.D, Chen, Y, Javid, B, Fraser, J.S. | | Deposit date: | 2024-03-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (2.47 Å) | | Cite: | Ribosomal RNA methylation by GidB is a capacitor for discrimination of mischarged tRNA
To be published
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2BDM
 | | Structure of Cytochrome P450 2B4 with Bound Bifonazole | | Descriptor: | 1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, ... | | Authors: | Zhao, Y, White, M.A, Muralidhara, B.K, Sun, L, Halpert, J.R, Stout, C.D. | | Deposit date: | 2005-10-20 | | Release date: | 2005-12-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
J.Biol.Chem., 281, 2006
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3FMS
 | | Crystal structure of TM0439, a GntR transcriptional regulator | | Descriptor: | ACETATE ION, NICKEL (II) ION, Transcriptional regulator, ... | | Authors: | Zheng, M, Cooper, D.R, Yu, M, Hung, L.-W, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | | Deposit date: | 2008-12-22 | | Release date: | 2009-02-10 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.
Acta Crystallogr.,Sect.D, 65, 2009
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3FN1
 | | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. | | Descriptor: | NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F | | Authors: | Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-03-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
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3FDL
 | | Bim BH3 peptide in complex with Bcl-xL | | Descriptor: | Apoptosis regulator Bcl-X, Bcl-2-like protein 11 | | Authors: | Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M. | | Deposit date: | 2008-11-26 | | Release date: | 2009-03-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
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9C8U
 | | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | | Descriptor: | Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... | | Authors: | Abe, K.M, Li, G, He, Q, Grant, T, Lim, C. | | Deposit date: | 2024-06-13 | | Release date: | 2024-09-04 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing.
Nat Commun, 15, 2024
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9DJU
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9DUM
 | | Human PELP1-WDR18-TEX10 complex | | Descriptor: | Proline-, glutamic acid- and leucine-rich protein 1, Testis-expressed protein 10, ... | | Authors: | Huang, J, Tong, L. | | Deposit date: | 2024-10-03 | | Release date: | 2025-04-30 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Molecular insights into the overall architecture of human rixosome.
Nat Commun, 16, 2025
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9DNB
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9DJ7
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9DK0
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9DN5
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