2DA6
| Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) | Descriptor: | Hepatocyte nuclear factor 1-beta | Authors: | Ohnishi, S, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-13 | Release date: | 2006-12-26 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) To be Published
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2D9Q
| Crystal Structure of the Human GCSF-Receptor Signaling Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CSF3, Granulocyte colony-stimulating factor receptor | Authors: | Tamada, T, Kuroki, R. | Deposit date: | 2005-12-12 | Release date: | 2006-02-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DA3
| Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) | Descriptor: | Alpha-fetoprotein enhancer binding protein | Authors: | Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-13 | Release date: | 2006-06-13 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
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2I40
| Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor | Descriptor: | 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE, Cell division protein kinase 2, Cyclin-A2 | Authors: | Shewchuk, L.M. | Deposit date: | 2006-08-21 | Release date: | 2006-10-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase Bioorg.Med.Chem.Lett., 16, 2006
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1BI7
| MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX | Descriptor: | CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR | Authors: | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1998-06-22 | Release date: | 1999-01-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395, 1998
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6TJM
| Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by Pyrrolidone1 | Descriptor: | 14-3-3 protein sigma, 5-[(2~{R})-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, C-terminal phosphopeptide of human estrogen receptor alpha, ... | Authors: | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | Deposit date: | 2019-11-26 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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6TLF
| human 14-3-3 sigma isoform in complex with IMP | Descriptor: | 14-3-3 protein sigma, INOSINIC ACID, SULFATE ION | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2019-12-02 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
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4HR9
| Human interleukin 17A | Descriptor: | Interleukin-17A | Authors: | Liu, S. | Deposit date: | 2012-10-26 | Release date: | 2013-05-22 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nat Commun, 4, 2013
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6TM7
| Human 14-3-3 sigma isoform in complex with PLP | Descriptor: | 14-3-3 protein sigma, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2019-12-03 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
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6TLD
| Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 2 | Descriptor: | DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... | Authors: | Shaik, T.B, Romier, C. | Deposit date: | 2019-12-02 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. Chemmedchem, 15, 2020
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1LFU
| NMR Solution Structure of the Extended PBX Homeodomain Bound to DNA | Descriptor: | 5'-D(*GP*CP*GP*CP*AP*TP*GP*AP*TP*TP*GP*CP*CP*C)-3', 5'-D(*GP*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*CP*GP*C)-3', homeobox protein PBX1 | Authors: | Sprules, T, Green, N, Featherstone, M, Gehring, K. | Deposit date: | 2002-04-12 | Release date: | 2003-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Lock and Key Binding of the HOX YPWM Peptide to the PBX Homeodomain J.Biol.Chem., 278, 2003
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4HSA
| Structure of interleukin 17a in complex with il17ra receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | Authors: | Liu, S. | Deposit date: | 2012-10-29 | Release date: | 2013-05-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nat Commun, 4, 2013
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1LQC
| LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES | Descriptor: | LAC REPRESSOR | Authors: | Slijper, M, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | Deposit date: | 1996-08-13 | Release date: | 1997-02-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator. J.Mol.Biol., 259, 1996
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6TWZ
| 14-3-3 sigma complexed with a phosphorylated 16E6 peptide | Descriptor: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D(-)-TARTARIC ACID, ... | Authors: | Gogl, G, Cousido-Siah, A, Sluchanko, N.N, Trave, G. | Deposit date: | 2020-01-13 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
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1LFB
| THE X-RAY STRUCTURE OF AN ATYPICAL HOMEODOMAIN PRESENT IN THE RAT LIVER TRANSCRIPTION FACTOR LFB1(SLASH)HNF1 AND IMPLICATIONS FOR DNA BINDING | Descriptor: | LIVER TRANSCRIPTION FACTOR (LFB1) | Authors: | Ceska, T.A, Lamers, M, Monaci, P, Nicosia, A, Cortese, R, Suck, D. | Deposit date: | 1993-06-28 | Release date: | 1993-10-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J., 12, 1993
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2P2T
| Crystal structure of dynein light chain LC8 bound to residues 123-138 of intermediate chain IC74 | Descriptor: | ACETATE ION, Dynein intermediate chain peptide, Dynein light chain 1, ... | Authors: | Benison, G, Karplus, P.A, Barbar, E. | Deposit date: | 2007-03-07 | Release date: | 2008-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site. J.Mol.Biol., 371, 2007
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6U2U
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1N1J
| Crystal structure of the NF-YB/NF-YC histone pair | Descriptor: | NF-YB, NF-YC | Authors: | Romier, C, Cocchiarella, F, Mantovani, R, Moras, D. | Deposit date: | 2002-10-18 | Release date: | 2003-02-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y J.Biol.Chem., 278, 2003
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2X6U
| Crystal structure of human TBX5 in the DNA-free form | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX5 | Authors: | Stirnimann, C.U, Mueller, C.W. | Deposit date: | 2010-02-22 | Release date: | 2010-04-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form. J.Mol.Biol., 400, 2010
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1E3O
| Crystal structure of Oct-1 POU dimer bound to MORE | Descriptor: | 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M. | Deposit date: | 2000-06-20 | Release date: | 2001-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
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2XP6
| DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION | Descriptor: | 2-(3-CHLORO-PHENYL)-5-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID, DODECAETHYLENE GLYCOL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 | Authors: | Potter, A, Oldfield, V, Nunns, C, Fromont, C, Ray, S, Northfield, C.J, Bryant, C.J, Scrace, S.F, Robinson, D, Matossova, N, Baker, L, Dokurno, P, Surgenor, A.E, Davis, B.E, Richardson, C.M, Murray, J.B, Moore, J.D. | Deposit date: | 2010-08-25 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20, 2010
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1NDD
| STRUCTURE OF NEDD8 | Descriptor: | CHLORIDE ION, PROTEIN (UBIQUITIN-LIKE PROTEIN NEDD8), SULFATE ION | Authors: | Whitby, F.G, Xia, G, Pickart, C.M, Hill, C.P. | Deposit date: | 1998-08-21 | Release date: | 1999-02-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J.Biol.Chem., 273, 1998
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2X6V
| Crystal structure of human TBX5 in the DNA-bound and DNA-free form | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 5'-D(*TP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP)-3', 5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP)-3', ... | Authors: | Ptchelkine, D, Stirnimann, C.U, Grimm, C, Mueller, C.W. | Deposit date: | 2010-02-22 | Release date: | 2010-04-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form. J.Mol.Biol., 400, 2010
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1CJU
| COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ... | Authors: | Tesmer, J.J.G, Sprang, S.R. | Deposit date: | 1999-04-16 | Release date: | 1999-08-31 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
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6VBU
| Structure of the bovine BBSome complex | Descriptor: | BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... | Authors: | Singh, S.K, Gui, M, Koh, F, Yip, M.C.J, Brown, A. | Deposit date: | 2019-12-19 | Release date: | 2020-01-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and activation mechanism of the BBSome membrane protein trafficking complex. Elife, 9, 2020
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