6TLD
Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 2
Summary for 6TLD
Entry DOI | 10.2210/pdb6tld/pdb |
Descriptor | Histone deacetylase, ZINC ION, POTASSIUM ION, ... (7 entities in total) |
Functional Keywords | epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase |
Biological source | Schistosoma mansoni |
Total number of polymer chains | 4 |
Total formula weight | 206030.09 |
Authors | Shaik, T.B.,Romier, C. (deposition date: 2019-12-02, release date: 2019-12-18, Last modification date: 2024-01-24) |
Primary citation | Kalinin, D.V.,Jana, S.K.,Pfafenrot, M.,Chakrabarti, A.,Melesina, J.,Shaik, T.B.,Lancelot, J.,Pierce, R.J.,Sippl, W.,Romier, C.,Jung, M.,Holl, R. Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. Chemmedchem, 15:571-584, 2020 Cited by PubMed: 31816172DOI: 10.1002/cmdc.201900583 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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