6HAX
| Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | Deposit date: | 2018-08-09 | Release date: | 2019-06-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
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3DOW
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3V3T
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6IXR
| Structure of Myo2-GTD in complex with Inp2 | Descriptor: | Inheritance of peroxisomes protein 2, Myosin-2, SULFATE ION | Authors: | Tang, K, Wei, Z. | Deposit date: | 2018-12-11 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.854 Å) | Cite: | Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem., 294, 2019
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3C5K
| Crystal structure of human HDAC6 zinc finger domain | Descriptor: | Histone deacetylase 6, ZINC ION | Authors: | Dong, A, Ravichandran, M, Schuetz, A, Loppnau, P, Li, Y, MacKenzie, F, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Dhe-Paganon, S, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-31 | Release date: | 2008-02-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of Human HDAC6 zinc finger domain. To be Published
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7NRN
| NMR structure of GIPC1-GH2 domain | Descriptor: | PDZ domain-containing protein GIPC1 | Authors: | Barthe, P, Roumestand, C. | Deposit date: | 2021-03-04 | Release date: | 2021-04-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1. Int J Mol Sci, 22, 2021
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6HR2
| Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | Authors: | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | Deposit date: | 2018-09-26 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
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3S29
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3D32
| Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide | Descriptor: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, K1 peptide, ... | Authors: | Weiergraeber, O.H, Stangler, T, Willbold, D. | Deposit date: | 2008-05-09 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Ligand Binding Mode of GABA(A) Receptor-Associated Protein. J.Mol.Biol., 381, 2008
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3CJ7
| Structure of Rattus norvegicus NTPDase2 in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Ectonucleoside triphosphate diphosphohydrolase 2 | Authors: | Zebisch, M, Strater, N. | Deposit date: | 2008-03-12 | Release date: | 2008-04-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling Proc.Natl.Acad.Sci.Usa, 105, 2008
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6IXO
| Apo structure of Myo2-GTD | Descriptor: | CHLORIDE ION, Myosin-2, SULFATE ION | Authors: | Tang, K, Wei, Z. | Deposit date: | 2018-12-11 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem., 294, 2019
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3CX2
| Crystal structure of the C1 domain of cardiac isoform of myosin binding protein-C at 1.3A | Descriptor: | Myosin-binding protein C, cardiac-type | Authors: | Fisher, S.J, Helliwell, J.R, Khurshid, S, Govada, L, Redwood, C, Squire, J.M, Chayen, N.E. | Deposit date: | 2008-04-23 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C Acta Crystallogr.,Sect.D, 64, 2008
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6GJH
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6IXP
| Structure of Myo2-GTD in complex with Mmr1 | Descriptor: | Mitochondrial MYO2 receptor-related protein 1, Myosin-2 | Authors: | Tang, K, Wei, Z. | Deposit date: | 2018-12-11 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.733 Å) | Cite: | Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem., 294, 2019
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3WQT
| Staphylococcus aureus FtsA complexed with AMPPNP | Descriptor: | CHLORIDE ION, Cell division protein FtsA, MAGNESIUM ION, ... | Authors: | Fujita, J, Maeda, Y, Miyazaki, Y, Inoue, T, Matsumura, H. | Deposit date: | 2014-02-01 | Release date: | 2014-10-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of FtsA from Staphylococcus aureus FEBS Lett., 588, 2014
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3AGR
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3WQU
| Staphylococcus aureus FtsA complexed with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division protein FtsA, MAGNESIUM ION | Authors: | Fujita, J, Maeda, Y, Miyazaki, Y, Inoue, T, Matsumura, H. | Deposit date: | 2014-02-01 | Release date: | 2014-10-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of FtsA from Staphylococcus aureus FEBS Lett., 588, 2014
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3O47
| Crystal structure of ARFGAP1-ARF1 fusion protein | Descriptor: | ADP-ribosylation factor GTPase-activating protein 1, ADP-ribosylation factor 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Wang, H, Tong, Y, Nedyalkova, L, Tempel, W, Guan, X, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-26 | Release date: | 2010-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of ARFGAP1-ARF1 fusion protein to be published
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8XT1
| Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline | Descriptor: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8XT3
| Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline | Descriptor: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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4X1B
| Human serum transferrin with ferric ion bound at the C-lobe only | Descriptor: | FE (III) ION, GLYCEROL, MALONATE ION, ... | Authors: | Wang, M, Zhang, H, Sun, H. | Deposit date: | 2014-11-24 | Release date: | 2015-04-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | "Anion clamp" allows flexible protein to impose coordination geometry on metal ions Chem.Commun.(Camb.), 51, 2015
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6YXO
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6YXP
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2DS4
| Solution structure of the filamin domain from human tripartite motif protein 45 | Descriptor: | Tripartite motif protein 45 | Authors: | Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-06-21 | Release date: | 2006-12-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the filamin domain from human tripartite motif protein 45 To be Published
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2WL1
| Pyrin PrySpry domain | Descriptor: | 1,2-ETHANEDIOL, PYRIN, THIOCYANATE ION | Authors: | Weinert, C, Mittl, P.R, Gruetter, M.G. | Deposit date: | 2009-06-19 | Release date: | 2009-10-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever. J.Mol.Biol., 394, 2009
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