4X1B

Human serum transferrin with ferric ion bound at the C-lobe only

Summary for 4X1B

• Entry DOI: 10.2210/pdb4x1b/pdb
• Related: 4X1D
• Descriptor: Serotransferrin, FE (III) ION, MALONATE ION, ... (5 entities in total)
• Functional Keywords: transferrin, ytterbium, ferric, malonate, metal transport
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02787
• Total number of polymer chains: 1
• Total formula weight: 75534.46

Authors

Wang, M.,Zhang, H.,Sun, H. (deposition date: 2014-11-24, release date: 2015-04-08, Last modification date: 2024-10-23)

Primary citation

Wang, M.,Lai, T.P.,Wang, L.,Zhang, H.,Yang, N.,Sadler, P.J.,Sun, H.
"Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51:7867-7870, 2015

PubMed Abstract: X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.

PubMed: 25854324
DOI: 10.1039/c4cc09642h

Experimental method

X-RAY DIFFRACTION (2.45 Å)