3WQU

Staphylococcus aureus FtsA complexed with ATP

Summary for 3WQU

Entry DOI	10.2210/pdb3wqu/pdb
Related	3WQT
Descriptor	Cell division protein FtsA, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	actin-like fold, structural genomics
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	4
Total formula weight	221215.88
Authors	Fujita, J.,Maeda, Y.,Miyazaki, Y.,Inoue, T.,Matsumura, H. (deposition date: 2014-02-01, release date: 2014-10-08, Last modification date: 2024-03-20)
Primary citation	Fujita, J.,Maeda, Y.,Nagao, C.,Tsuchiya, Y.,Miyazaki, Y.,Hirose, M.,Mizohata, E.,Matsumoto, Y.,Inoue, T.,Mizuguchi, K.,Matsumura, H. Crystal structure of FtsA from Staphylococcus aureus FEBS Lett., 588:1879-1885, 2014 Cited by PubMed Abstract: The bacterial cell-division protein FtsA anchors FtsZ to the cytoplasmic membrane. But how FtsA and FtsZ interact during membrane division remains obscure. We have solved 2.2 Å resolution crystal structure for FtsA from Staphylococcus aureus. In the crystals, SaFtsA molecules within the dimer units are twisted, in contrast to the straight filament of FtsA from Thermotoga maritima, and the half of S12-S13 hairpin regions are disordered. We confirmed that SaFtsZ and SaFtsA associate in vitro, and found that SaFtsZ GTPase activity is enhanced by interaction with SaFtsA. PubMed: 24746687 DOI: 10.1016/j.febslet.2014.04.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation