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7BV2	The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... Authors: Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. Deposit date: 2020-04-09 Release date: 2020-04-22 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
2XI5	N-terminal endonuclease domain of La Crosse virus L-protein Descriptor: MANGANESE (II) ION, RNA POLYMERASE L Authors: Reguera, J, Weber, F, Cusack, S. Deposit date: 2010-06-28 Release date: 2010-10-06 Last modified: 2012-07-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription. Plos Pathog., 6, 2010
2XI7	N-terminal endonuclease domain of La Crosse virus L-protein Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, RNA POLYMERASE L Authors: Reguera, J, Weber, F, Cusack, S. Deposit date: 2010-06-28 Release date: 2010-10-06 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription. Plos Pathog., 6, 2010
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-27 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8R3L	Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8R3K	Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A. Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, PYROPHOSPHATE 2-, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
1TQL	POLIOVIRUS POLYMERASE G1A MUTANT Descriptor: ACETIC ACID, RNA-directed RNA polymerase Authors: Thompson, A.A, Peersen, O.B. Deposit date: 2004-06-17 Release date: 2004-08-17 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase Embo J., 23, 2004
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
3C2P	X-ray crystal structure of the N4 mini-vRNAP P1 promoter complex Descriptor: P1 Promoter DNA, Virion RNA polymerase Authors: Gleghorn, M.L, Murakami, K.S. Deposit date: 2008-01-25 Release date: 2008-12-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol.Cell, 32, 2008
3C3L	X-ray crystal structure of the N4 mini-vRNAP P2 promoter complex Descriptor: P2 Promoter DNA, Virion RNA polymerase Authors: Gleghorn, M.L, Murakami, K.S. Deposit date: 2008-01-28 Release date: 2008-12-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol.Cell, 32, 2008
3C46	X-ray crystal structure of the N4 mini-vRNAP P2_7a promoter complex soaked with MgCl2 Descriptor: DIHYDROGENPHOSPHATE ION, P2_7a Promoter DNA, Virion RNA polymerase Authors: Gleghorn, M.L, Murakami, K.S. Deposit date: 2008-01-29 Release date: 2008-12-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol.Cell, 32, 2008
1P16	Structure of an mRNA capping enzyme bound to the phosphorylated carboxyl-terminal domain of RNA polymerase II Descriptor: GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... Authors: Fabrega, C, Shen, V, Shuman, S, Lima, C.D. Deposit date: 2003-04-11 Release date: 2003-07-15 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Mol.Cell, 11, 2003
4GZK	Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 Descriptor: FORMIC ACID, MAGNESIUM ION, RNA-dependent RNA polymerase P2 Authors: Ren, Z, Franklin, M, Ghose, R. Deposit date: 2012-09-06 Release date: 2013-07-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins, 81, 2013
1HMJ	SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H Descriptor: PROTEIN (SUBUNIT H) Authors: Thiru, A, Hodach, M, Eloranta, J, Kostourou, V, Weinzierl, R. Deposit date: 1999-02-05 Release date: 1999-04-05 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes. J.Mol.Biol., 287, 1999
4FF3	N4 mini-vRNAP transcription initiation complex, 3 min after soaking GTP, ATP and Mn Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Bacteriophage N4 P2 promoter, GUANOSINE-5'-MONOPHOSPHATE, ... Authors: Murakami, K.S, Basu, R.S. Deposit date: 2012-05-30 Release date: 2012-12-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.997 Å) Cite: Watching the Bacteriophage N4 RNA Polymerase Transcription by Time-dependent Soak-trigger-freeze X-ray Crystallography. J.Biol.Chem., 288, 2013
4FF4	N4 mini-vRNAP transcription initiation complex, 4 min after soaking GTP, ATP and Mn Descriptor: ADENOSINE MONOPHOSPHATE, Bacteriophage N4 P2 promoter, GUANOSINE-5'-MONOPHOSPHATE, ... Authors: Murakami, K.S. Deposit date: 2012-05-31 Release date: 2012-12-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.026 Å) Cite: Watching the Bacteriophage N4 RNA Polymerase Transcription by Time-dependent Soak-trigger-freeze X-ray Crystallography. J.Biol.Chem., 288, 2013
4FF1	N4 mini-vRNAP transcription initiation complex, 1 min after soaking GTP, ATP and Mn Descriptor: Bacteriophag N4 P2 promoter, PHOSPHATE ION, Virion RNA polymerase Authors: Murakami, K.S, Basu, R.S. Deposit date: 2012-05-30 Release date: 2012-12-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Watching the Bacteriophage N4 RNA Polymerase Transcription by Time-dependent Soak-trigger-freeze X-ray Crystallography. J.Biol.Chem., 288, 2013
4FF2	N4 mini-vRNAP transcription initiation complex, 2 min after soaking GTP, ATP and Mn Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Bacteriophage N4 P2 promoter, GUANOSINE-5'-MONOPHOSPHATE, ... Authors: Murakami, K.S, Basu, R.S. Deposit date: 2012-05-30 Release date: 2012-12-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Watching the Bacteriophage N4 RNA Polymerase Transcription by Time-dependent Soak-trigger-freeze X-ray Crystallography. J.Biol.Chem., 288, 2013
7AAP	Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP Descriptor: MAGNESIUM ION, Non-structural protein 12, Non-structural protein 7, ... Authors: Naydenova, K, Muir, K.W, Wu, L.F, Zhang, Z, Coscia, F, Peet, M, Castro-Hartman, P, Qian, P, Sader, K, Dent, K, Kimanius, D, Sutherland, J.D, Lowe, J, Barford, D, Russo, C.J. Deposit date: 2020-09-04 Release date: 2020-09-23 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP. Proc.Natl.Acad.Sci.USA, 118, 2021
3E3J	Crystal Structure of an Intermediate Complex of T7 RNAP and 8nt of RNA Descriptor: DNA (28-MER), DNA (5'-D(*DTP*DAP*DAP*DTP*DAP*DCP*DGP*DAP*DCP*DTP*DCP*DAP*DCP*DTP*DAP*DTP*DAP*DTP*DTP*DTP*DCP*DTP*DGP*DCP*DCP*DAP*DAP*DAP*DCP*DGP*DGP*DC)-3'), DNA-directed RNA polymerase, ... Authors: Durniak, K.J, Bailey, S, Steitz, T.A. Deposit date: 2008-08-07 Release date: 2008-11-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (6.7 Å) Cite: The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation Science, 322, 2008
4NJC	RNA Polymerase interacting protein YkzG from Geobacillus stearothermophilus Descriptor: Geobacillus stearothermophilus YkzG Authors: Keller, A.N, Lewis, P.J. Deposit date: 2013-11-09 Release date: 2014-08-20 Last modified: 2014-10-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: epsilon, a New Subunit of RNA Polymerase Found in Gram-Positive Bacteria J.Bacteriol., 196, 2014
7NFR	Fujian capmidlink domain in complex with Nb8194 Descriptor: GLYCEROL, NB8194, Polymerase basic protein 2, ... Authors: Keown, J.R, Grimes, J.M, Fodor, E. Deposit date: 2021-02-07 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NFQ	Fujian capmidlink domain in complex with Nb8193 Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Nb8193, ... Authors: Keown, J.R, Grimes, J.M, Fodor, E. Deposit date: 2021-02-07 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
7NFT	Fujian capbinding domain in complex with Nb8208 Descriptor: Nb8208, Polymerase basic protein 2, SULFATE ION Authors: Keown, J.R, Grimes, J.M, Fodor, E. Deposit date: 2021-02-07 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.14 Å) Cite: Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022

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