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1F24	CRYSTAL STRUCTURE OF NO COMPLEX OF THR243ALA MUTANTS OF CYTOCHROME P450NOR Descriptor: GLYCEROL, NITRIC OXIDE, NITRIC OXIDE REDUCTASE, ... Authors: Shimizu, H, Park, S.-Y. Deposit date: 2000-05-23 Release date: 2000-11-23 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. J.Inorg.Biochem., 82, 2000
1F25	CRYSTAL STRUCTURE OF NO COMPLEX OF THR243ASN MUTANTS OF CYTOCHROME P450NOR Descriptor: GLYCEROL, NITRIC OXIDE, NITRIC OXIDE REDUCTASE, ... Authors: Shimizu, H, Park, S.-Y. Deposit date: 2000-05-23 Release date: 2000-11-23 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. J.Inorg.Biochem., 82, 2000
4BJK	CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide Descriptor: 3,3'-difluoro-N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl]biphenyl-4-carboxamide, LANOSTEROL 14-ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE Authors: Podust, L.M. Deposit date: 2013-04-18 Release date: 2013-09-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 as Anti-Chagas Agents. J.Med.Chem., 56, 2013
1IO9	THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES Descriptor: CYTOCHROME P450 CYP119, PROTOPORPHYRIN IX CONTAINING FE Authors: Park, S.-Y, Yamane, K, Adachi, S, Shiro, Y, Sligar, S.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2001-02-08 Release date: 2001-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J.Inorg.Biochem., 91, 2002
1IO8	Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: High resolution structural origin of its thermostability and functional properties Descriptor: CYTOCHROME P450 CYP119, PROTOPORPHYRIN IX CONTAINING FE Authors: Park, S.-Y, Yamane, K, Adachi, S, Shiro, Y, Sligar, S.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2001-02-08 Release date: 2001-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties J.Inorg.Biochem., 91, 2002
4B7D	PikC bound to the 10-DML analog with the 3-(N,N-dimethylamino) propanoate anchoring group Descriptor: CYTOCHROME P450 HYDROXYLASE PIKC, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Podust, L.M. Deposit date: 2012-08-17 Release date: 2013-08-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Recognition of Synthetic Substrates by P450 Pikc To be Published
1IWI	Putidaredoxin-Binding Stablilizes an Active Conformer of Cytochrome P450cam in its Reduced State; Crystal Structure of Cytochrome P450cam Descriptor: CAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE Authors: Nagano, S, Shimada, H, Tarumi, A, Hishiki, T, Kimata-Ariga, Y, Egawa, T, Park, S.-Y, Adachi, S, Shiro, Y, Ishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2002-05-15 Release date: 2002-06-05 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam Biochemistry, 42, 2003
5IBF	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 19a Descriptor: 4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Levy, C. Deposit date: 2016-02-22 Release date: 2016-04-06 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
4L49	Structure of L358A mutant of P450cam bound to camphor Descriptor: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... Authors: Batabyal, D, Li, H, Poulos, T.L. Deposit date: 2013-06-07 Release date: 2013-07-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.128 Å) Cite: Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1. Biochemistry, 52, 2013
5IKI	CYP106A2 WITH SUBSTRATE ABIETIC ACID Descriptor: Abietic acid, Cytochrome P450(MEG), PROTOPORPHYRIN IX CONTAINING FE Authors: Janocha, S, Carius, Y, Bernhardt, R, Lancaster, C.R.D. Deposit date: 2016-03-03 Release date: 2016-05-25 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound Form. Chembiochem, 17, 2016
4L4G	Structure of cyanide and camphor bound P450cam mutant L358P/K178G Descriptor: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... Authors: Batabyal, D, Li, H, Poulos, T.L. Deposit date: 2013-06-07 Release date: 2013-07-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1. Biochemistry, 52, 2013
4MGJ	Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI Descriptor: 4-(4-CHLOROPHENYL)IMIDAZOLE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE Authors: Yang, Y, Zhang, H, Usharani, D, Bu, W, Im, S, Tarasev, M, Rwere, F, Meagher, J, Sun, C, Stuckey, J, Shaik, S, Waskell, L. Deposit date: 2013-08-28 Release date: 2014-08-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond. Biochemistry, 53, 2014
5IBI	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 26a Descriptor: 4,4'-(5-{[(4-hydroxyphenyl)methyl]amino}-1H-pyrazole-3,4-diyl)diphenol, Cytochrome P450 121 CYP121, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Levy, C. Deposit date: 2016-02-22 Release date: 2016-04-06 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IRV	Human cytochrome P450 17A1 bound to inhibitor VT-464 Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase, VT-464 Authors: Scott, E.E, Petrunak, E.M. Deposit date: 2016-03-14 Release date: 2017-03-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.098 Å) Cite: Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Drug Metab. Dispos., 45, 2017
4LXJ	Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound Descriptor: LANOSTEROL, Lanosterol 14-alpha demethylase, OXYGEN MOLECULE, ... Authors: Monk, B.C, Tomasiak, T.M, Keniya, M.V, Huschmann, F.U, Tyndall, J.D.A, O'Connell III, J.D, Cannon, R.D, McDonald, J, Rodriguez, A, Finer-Moore, J, Stroud, R.M. Deposit date: 2013-07-29 Release date: 2014-01-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc.Natl.Acad.Sci.USA, 111, 2014
5IBE	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 25a Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[5-amino-4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-3-yl]phenol, Mycocyclosin synthase, ... Authors: Levy, C. Deposit date: 2016-02-22 Release date: 2016-04-06 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.624 Å) Cite: Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IBJ	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 6 Descriptor: 4-{5-[(4-hydroxyphenyl)amino]-1H-pyrazol-3-yl}phenol, Cytochrome P450 121 CYP121, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Levy, C. Deposit date: 2016-02-22 Release date: 2016-04-06 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IRQ	Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel Descriptor: (R)-orteronel, (S)-orteronel, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Scott, E.E, Petrunak, E.M. Deposit date: 2016-03-14 Release date: 2017-03-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.202 Å) Cite: Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Drug Metab. Dispos., 45, 2017
5IUZ	STRUCTURE OF P450 2B4 F202W MUTANT (CYMAL-5) Descriptor: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE Authors: Jang, H.-H, Halpert, J.R, Shah, M.B. Deposit date: 2016-03-18 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophys.Chem., 216, 2016
4MM0	Crystal Structure Analysis of the Putative Thioether Synthase SgvP Involved in the Tailoring Step of Griseoviridin Descriptor: P450-like monooxygenase, PROTOPORPHYRIN IX CONTAINING FE Authors: Zhang, H, Huang, L, Yi, M, Cai, T, Zhang, H. Deposit date: 2013-09-07 Release date: 2014-09-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin To be Published
5IUT	STRUCTURE OF P450 2B4 F202W MUTANT Descriptor: 3,6,9,12,15,18-hexaoxahexacosan-1-ol, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE Authors: Jang, H.-H, Halpert, J.R, Shah, M.B. Deposit date: 2016-03-18 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophys.Chem., 216, 2016
5JKV	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL Descriptor: 4-ANDROSTENE-3-17-DIONE, Aromatase, PENTAETHYLENE GLYCOL, ... Authors: Ghosh, D, Lo, J, Egbuta, C. Deposit date: 2016-04-26 Release date: 2017-04-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Testosterone complex and non-steroidal ligands of human aromatase. J. Steroid Biochem. Mol. Biol., 2018
4L4F	Structure of cyanide and camphor bound P450cam mutant L358A/K178G/D182N Descriptor: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... Authors: Batabyal, D, Li, H, Poulos, T.L. Deposit date: 2013-06-07 Release date: 2013-07-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.294 Å) Cite: Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1. Biochemistry, 52, 2013
4L77	P450cin Active Site Water: Implications for Substrate Binding and Solvent Accessibility Descriptor: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE, DI(HYDROXYETHYL)ETHER, P450cin, ... Authors: Madrona, Y, Poulos, T.L. Deposit date: 2013-06-13 Release date: 2013-07-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.379 Å) Cite: P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry, 52, 2013
5JL6	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #2 Descriptor: 4-ANDROSTENE-3-17-DIONE, Aromatase, PROTOPORPHYRIN IX CONTAINING FE Authors: Ghosh, D, Lo, J, Egbuta, C. Deposit date: 2016-04-26 Release date: 2017-04-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Testosterone complex and non-steroidal ligands of human aromatase. J. Steroid Biochem. Mol. Biol., 2018

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