5IRV
Human cytochrome P450 17A1 bound to inhibitor VT-464
Summary for 5IRV
| Entry DOI | 10.2210/pdb5irv/pdb |
| Related | 5IRQ |
| Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, VT-464 (3 entities in total) |
| Functional Keywords | oxidoreductase, inhibitor complex, lyase-inhibitor complex, lyase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 227023.87 |
| Authors | Scott, E.E.,Petrunak, E.M. (deposition date: 2016-03-14, release date: 2017-03-15, Last modification date: 2023-09-27) |
| Primary citation | Petrunak, E.M.,Rogers, S.A.,Aube, J.,Scott, E.E. Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Drug Metab. Dispos., 45:635-645, 2017 Cited by PubMed: 28373265DOI: 10.1124/dmd.117.075317 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.098 Å) |
Structure validation
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